One hundred and thirty-two cases(132 eyes) of corneal ulcer were analysed on the clinical and etiologic basis. The history of evident ocular trauma was found in 28.8% of the cases and ocular disease was found in 7.6% of the cases. Positive results were 16/55 in smear and 33/61 in culture, and the most common isolate was coagulase negative staphylococcus in bacteriologic studies. In fungal studies, positive results were 1/42 in smear and 5/42 in culture, and Aspergillus was the most common isolate. Cephalexin was the most sensitive antibiotics for Gram positive organism and carbenicillin and gentamicin were the most sensitive antibiotics for Gram negative orgamsm. These results indicate that gentamicin and cephalexin in combination would be recommended as the initial treatment of wide-spectrum antibiotics coverage for bacterial corneal ulcer until the final culture results and senitivity are available.
Anti-Bacterial Agents ; Aspergillus ; Carbenicillin ; Cephalexin ; Coagulase ; Corneal Ulcer* ; Gentamicins ; Staphylococcus

During The last 11 years from Jan. 1980 to Dec. 1990, 72 cases of salmonellosis has been admitted to the Department of Pediatrics of National Medical Center and evaluated clinical difference between typhoid fever and salmonella gastroenteritis. The results were as follows: 1) The annual incidence of salmonella gastroenteritis insalmonellosis was increased in the latter half of the eighties. 2) Both salmonellosis had its peak incidence in the summer. 3) Salmonella gastroenteritis was highest in the age of less than 5 year in contrast with the age of 6~9 year in typhoid fever. 4) The specimens isolated salmonellae were blood and stool in most cases, especially blood in typhoid fever and stool in gastroenteritis. 5) S.typhi was 16 cases, salmonella group A was 3 cases, group B was 16 cases and Group D and E were a case in each in isolated salmonellae. 6) On the antibiotic sensitivity test, S.typhi was sensitive to the most antibiotics. but the salmonella group B was relatively resisitant to Ampicillin, Carbenicillin, Tetracycline and Chloramphenicol.
Ampicillin ; Anti-Bacterial Agents ; Carbenicillin ; Chloramphenicol ; Gastroenteritis ; Incidence ; Pediatrics ; Salmonella ; Salmonella Infections* ; Tetracycline ; Typhoid Fever

In clinical practice, we have occasionally experienced the difficulty to identify the pathologic changes of the non or faint-visualized kidney induced by ureteral stone on I.V.P. and especially to decide whether upper urinary tract infection of ipsilateral side was in accordance with lower urinary tract infection or not. We have checked routinely the bacteriological study of the urine collected from the ureterolithotomized site on operation during last two years. Following results were obtained: 1) Among the cultured urine of 42 patients, organism detected in 20 patients and no growth in remainder. Colifrom bacilli 11(26.2%) Staphylococci 5(11.9%) Streptococci 1(2.4%) Pseudomonas 1(2.4%) TB bacilli 2(4.7%) 2) Sensitive drug pattern of 18 patients, Coliform bacilli (11): Kanamycin, Streptomycin, Chloramphenicol Staphylococcus (5): Penicillin, Kanamycin Streptococcus (1): Penicillin Pseudomonas (1): Geopen From above results, some advantages has been provided in the post-operative management of upper urinary tract infection after removal of the ureteral stone.
Carbenicillin ; Chloramphenicol ; Enterobacteriaceae ; Humans ; Kanamycin ; Kidney ; Penicillins ; Pseudomonas ; Staphylococcus ; Streptococcus ; Streptomycin ; Ureter* ; Urinary Tract Infections* ; Urinary Tract*

Vibrio alginolyticus is a microorganism of marine environment that occasionally occurs as a human pathogen. We isolated V. alginolyticus from a patient with otitis media. A 37-year-old man had been exposed to seawater one month before admission. The isolate showed typical biochemical and characteristics of this organism such as positive Voges-Proskauer reaction, fermentation of sucrose, growth on 10% sodium chloride media. In vitro susceptibility test shows the isolate was resistant to ampicillin and carbenicillin, but was susceptible to other antimicrobial agents. The patient improved with ciprofloxacin and ofloxacin therapy.
Adult ; Ampicillin ; Anti-Infective Agents ; Carbenicillin ; Ciprofloxacin ; Fermentation ; Humans ; Ofloxacin ; Otitis Media* ; Otitis* ; Seawater ; Sodium Chloride ; Sucrose ; Vibrio alginolyticus* ; Vibrio*

During the period from Jan. 1978 to June 1978, clinical and laboratory observations were done on the 46 cases of gonorrhea and 40 cases of non-specific urethritis at random selection in the Department of Urology, Korea University Hospital. The following results were obtained: 1. The average age of the gonorrheal patients were 24 years old and 30 years in non-specific urethritis patients. 2. The main clinical symptoms of gonorrheal patients were profuse yellowish urethral discharge found in 91.3 % of cases and painful urination in 37 %. The symptoms of non-specific urethritis patients showed scanty urethral discharge in 525 % of cases and urethral discomfort in 25%. 3. The incubation period of gonorrheal cases was 3 to 7 days while in one-fourth of non-specific urethritis the period was shorter than 10 days. 4. In the past history 43.5 % of gonorrheal patients had V. D. and 62.5 % of non-specific urethritis patients had them. 5. In 20 cases ( 50%) of non-specific urethritis had positive shred culture with no evidence of positive findings in urinalysis or in Gram stain of urine sediment. 6. In 31 cases(77.5%) of positive shred cultures, staphy lococcus albus were grown in 12 cases, diphtheroid in 10 cases, mixed growth of staphylococcus albus and diphtheroid in 5 cases. Antimicrobial sensitivity test with Gram(+) cocci obtained from 19 cases of nonspecific urethritis showed highly sensitive resultes to hentamicin, lincomycin, carbenicillin, novobiocin and highly resistant reactions to oxytetracycline. 7. 82.6% of cases of gonococcal infection were cultured on the Thayer-Martin medium and antimicrobial sensitivity test was done with these colonies by disc diffusion method. Penicillin and its derivatives were highly sensitive, other antibiotics such as erythromycin, oxytetracycline, chloramphenicol and gentamicin were also sensitive.
Anti-Bacterial Agents ; Carbenicillin ; Chloramphenicol ; Diffusion ; Erythromycin ; Gentamicins ; Gonorrhea* ; Humans ; Korea ; Lincomycin ; Novobiocin ; Oxytetracycline ; Penicillins ; Staphylococcus ; Urethritis* ; Urinalysis ; Urination ; Urology ; Young Adult

Morganella morganii, a gram, negative rod is often regarded as an opportunistic, secondary invader rather than a primary pathogen on the skin. It has been isolated from blood, sputa, and pus from patients with respiratory tract and wound infections or with bacteremia. A 2-year-old boy presented with erythematous ulcerative lesions on the cheeks and left knee which had a tendency to superficial scarring. The organism isolated from the ulcer displayed a biochemical char acteristics typical of Morganella morganii. The lesions responded well to systemic antibiotic therapy with amikacin and carbenicillin, which were recognized as effective drugs in in vitro sensitivity testing.
Amikacin ; Bacteremia ; Carbenicillin ; Cheek ; Child, Preschool ; Cicatrix ; Humans ; Knee ; Male ; Morganella morganii* ; Morganella* ; Respiratory System ; Skin Ulcer* ; Skin* ; Suppuration ; Trout ; Ulcer ; Wound Infection

In 57 hospitalized patients with temporary closed sterile urinary-catheter drainage, incidence of acquired bacteriuria was evaluated by culture, colony count, drug sensitivity and the following results were obtained. 1. Incidence of infection was 0% within 3 days, 18.2%o within 5 days, 41.7% within 7 days, 60.9%0 after 7 days. 2. Of 117 bacterial strains isolated by culture of urine 82.1%o was gram negative bacteria and 17.1%o was gram positive. The frequency of isolated organisms were as followings: Escherichia coli ............. 44.4%, Pseudomonas aeruginosa ............. 19.7%, Staphylococci ............. 14.5%, Caliform bacilli ............. 9.5%, Proteus ............. 6.8%, Streptococci ............. 4.2%, Yeast ............. 0.9%. 3. Most organisms were highly resistant to any of antibiotics which were Kanamycin, Gentamicin, Ampicillin, Streptomycin, Tetracycline, Cephoran, Geopen, Amiktam. 4. Closed sterile drainage system was much effective in delaying bacteriuria than open drainage system in comparison with 70.8% of bacteriuria within the first 3 days of open catheter drainage demonstrated in previous report.
Ampicillin ; Anti-Bacterial Agents ; Bacteriuria ; Carbenicillin ; Catheters ; Drainage* ; Escherichia coli ; Gentamicins ; Gram-Negative Bacteria ; Humans ; Incidence ; Kanamycin ; Proteus ; Pseudomonas aeruginosa ; Streptomycin ; Tetracycline ; Urinary Tract Infections* ; Urinary Tract* ; Yeasts

In a world, ocular infection of Pseudomonas has been found in premature infants. This is so serious that corneal perforation and panophthalmitis are developed. And septicemia is developed. In these days, hospital infection due to pseudomonas tends to increasese. We experienced one case of pseudomonas dacryocystitis in a normal full term infant. At first, we diagnosed it as a blenorrhea neonatorum due to pseudomonas infection. And the smear of vagina of his mother was examined by Gram stain and culture. But, pseudomonas was not found. So, we considered that it was because of hospital infection. The patient was treated with carbenicillin 400 mg/day intramuscularly and 0.5% chloramphenicol solution everyone hour topically for 2 weeks. During this time there wa.s no improvement. After then we found obstruction of nasolacrimal ducts and performed probing once. After that this case was cured.
Carbenicillin ; Chloramphenicol ; Corneal Perforation ; Cross Infection ; Dacryocystitis* ; Eye Infections ; Humans ; Infant ; Infant, Newborn ; Infant, Premature ; Mothers ; Nasolacrimal Duct ; Panophthalmitis ; Pseudomonas Infections ; Pseudomonas* ; Sepsis ; Vagina

Clinical and bacteriological studies were carried out on 74 cases of infants and children with Shigellosis who were cared from May 1972 to Sept. 1977 in our hospital. 1) The age distribution revealed the range between 6 months and 5 ysers (85% of all) with the sex ratio of 42(57%) of male and 32(43%) of female, 13:1,0. 2) The peak incidence was noted in summer, although there were occurrence throughout the year, even in winter. 3) On bacteriological studies, Shigella flexneri was isolated most frequently (73%) and shigella sonnei was the next(32%). Since 1977, however, the rate of isolation was reversed as the former 32% and the latter 62%. 4) Up to 1976, ampicillin was the most effective (in 93%) and carbenicillin the next (in 87%) on sensitivity test. But gentamicin became hightly sensitive in 88%, kanamycin in 81% and ampicillin in 13% since 1977. 70% to 95% of isolated Shigellae were resistant to Terramycin, Chloromycetin, streptomycin and Colimycin. 5) The average duration from the onset to the clinical improvement including stool character was that of 3.4 days. 6) The mortality rate was 2.7% (2 of 74 patients) and they all were under 2 years of age.
Age Distribution ; Ampicillin ; Carbenicillin ; Child ; Chloramphenicol ; Colistin ; Dysentery, Bacillary* ; Female ; Gentamicins ; Humans ; Incidence ; Infant ; Kanamycin ; Male ; Mortality ; Oxytetracycline ; Sex Ratio ; Shigella ; Shigella flexneri ; Shigella sonnei ; Streptomycin

Conjugative R plasmids derived from 74 clinical isolates of Serratia marcescens were epidemiologically analyzed for antimicrobial resistance, EcoRI restriction endonuclease analysis and Southern hybridization with DHFR, TEM and SHV probe. 1. Resistance frequency of isolates against various B-lactam antibiotics was changed by year. 2. Twenty (27%) resistant strains transferred 32 R plasmids to E. coli or Klebsiella by mixed culture. Most strains isolated from 1994 to 1996 transferred only trimethoprim resistance but most strains isolated from 1997 did resistances against gentamicin (Gm) and B-lactams including ampicillin (Ap), carbenicillin (Cb), cefazolin (Cz), cefaloridine (Cl), cefamandole (Cn). 3. Ten plasmids of GmApCbCzC1Cn or GmApCbCzC1 pattern and 3 plasmids of TcSuGmTbApCbCzC1 pattern respectively showed identical EcoRI restriction endonuclease digestion patterns and hybridized fragment patterns with TEM-1 probe by Southern hybridization. These results indicate that the epidemic plasmids carrying blamM gene were present in this hospital in 1997 and molecular genetic analysis of R plasmids can be used to discriminate S. marcescens isolates for epidemiologic studies.
Ampicillin ; Anti-Bacterial Agents ; Carbenicillin ; Cefamandole ; Cefazolin ; Cephaloridine ; Digestion ; DNA Restriction Enzymes ; Epidemiologic Studies ; Epidemiology* ; Gentamicins ; Klebsiella ; Molecular Biology ; Plasmids ; R Factors ; Serratia marcescens* ; Serratia* ; Trimethoprim Resistance