32 patients (male: 21) with average ages of 62 (11,4, hypertension (systolic blood pressure: 180mmHg, diastolic blood pressure: 110 mmHg) received the sublingual captopril at dose of 25 mg. The hemodynamometery was implemented before and after 5, 15, 30 and 60 minutes of using the drug. If the blood pressure was not reduced to wanted level, the patient indicated more one tablet. If the blood pressure did not reduce about 25%, patients will be treated by combination of captopril with other drugs. The results have shown that efficacy at dose of 25 mg, 15 cases, at dose of 50 mg: 12 cases; ineffect and poor effect: 5 cases. Initial time of effect: 7 (1.04 minutes after using; time for maximum effect: 61 (24.3 minutes after using. The study concluded that captopril can be used in the urgent hypertension
Hypertension ; Captopril

No abstract available.
Captopril* ; Child* ; Humans ; Hypertension*

No abstract available.
Acidosis, Renal Tubular* ; Captopril*

to build formula of captopril sustained release matrix tablets with EC and HPMC, survey the affects of formulation components and optimization of formula by using D- Optimal. Subject: captopril, EC, HPMC, lactose, and starch. Method: prepare tablet, assess the quality of captopril sustained release matrix tablets. Conclusions: From the experiment design, captopril sustained release oral tablets with half life of 12h can be prepared, and by optimized method, the proper formula was found. To produce captopril tablets, it's necessary to further study in large scale, to perform test of bio-equivalence and stability of tablet
Captopril ; Tablets ; Pharmaceutical Preparations

No abstract available.
Captopril* ; Child* ; Humans ; Nephrotic Syndrome*

No abstract available.
Captopril* ; Child* ; Humans ; Nephrotic Syndrome*

No abstract available.
Captopril* ; Hypertension, Renovascular* ; Radionuclide Imaging*

No abstract available.
Acantholysis* ; Captopril* ; Penicillamine* ; Rifampin* ; Skin*

No abstract available.
Animals ; Captopril* ; Cisplatin* ; Nifedipine* ; Rats*

The hypotensive effect and side reactions of captopril (combination with hydrochlorthiazide in some cases) were evaluated in 42 patients with essential hypertension. The results were as follows: 1) Before medication and after 2, 4, 6, 8 and 10 weeks of medication, the over all average systolic & diastolic pressure were 178.2+/-42.6/111.3+/-21.1, 150.6+/-36.2/95.2+/-34.5, 140.3+/-31.4/93.6+/-24.3, 135.6+/-28.6/90.6+/-17.1, 130.9+/-20.5/87.9+/-16.4, 128.7+/-24.0/86.4+/-15.3mmHg respectively. After 10 weeks of medication, marked or moderate degree of hypotensive effect was observed in 98% of all cases (systolic pressure), 93% of all cases (diastolic pressure)(P<0.001, P<0.001). 2) There was no significant changes in heart rates before and after treatment. 3) There was no side effects which required discontinuing the medication, decreasing the dose or other treatment for side effects.
Blood Pressure ; Captopril* ; Heart Rate ; Humans ; Hypertension