1.Experimental study on inhibitory effect of capsaicin to nasalmucosal hyperreactivity.
Sang Hag LEE ; Jong Ouck CHOI ; Sun Hee LEE ; Seung Ho LEE ; Jong Tae YOON ; Hong Kyun YOO
Korean Journal of Otolaryngology - Head and Neck Surgery 1991;34(3):519-527
No abstract available.
Capsaicin*
2.The Role of Capsaicin in Spontaneous Pacemaking Activity in Gastrointestinal Tract.
Journal of Neurogastroenterology and Motility 2010;16(3):225-227
No abstract available.
Capsaicin
;
Gastrointestinal Tract
3.Effect of capsaicin on murine lymphocyte functions and lymphoid tissue morphology.
June Chul LEE ; Yeong Min PARK
Immune Network 2001;1(3):203-212
No abstract available.
Capsaicin*
;
Lymphocytes*
;
Lymphoid Tissue*
4.Effects of intranasal applications of capsaicin in patients with nonallergic eosinophilic nasal hyperreactivity.
Man Soo KIM ; Jong Tae YOON ; Sang Hag LEE ; Heung Man LEE ; Soon Jae HWANG
Korean Journal of Otolaryngology - Head and Neck Surgery 1993;36(2):274-282
No abstract available.
Capsaicin*
;
Eosinophils*
;
Humans
5.Ca2+-dependent Long-term Inactivation of Cardiac Na+/Ca2+ Exchanger.
The Korean Journal of Physiology and Pharmacology 2007;11(5):183-188
Using BHK cells with stable expression of cardiac Na+/Ca2+ exchanger (BHK-NCX1), reverse mode (i.e. Ca2+ influx mode) of NCX1 current was recorded by whole-cell patch clamp. Repeated stimulation of reverse NCX1 produced a cytosolic Ca2+-dependent long-term inactivation of the exchanger activity. The degrees of inactivation correlated with NCX1 densities of the cells and were attenuated by reduced Ca2+ influx via the reverse exchanger. The inactivation of NCX1 was attenuated by (i) inhibition of Ca2+ influx with reduced extracellular Ca2+, (ii) treatment with NCX1 blocker (Ni2+), and (iii) increase of cytoplasmic Ca2+ buffer (EGTA). In BHK-NCX1 cells transiently expressing TRPV1 channels, Ca2+ influx elicited by capsaicin produced a marked inactivation of NCX1. We suggest that cytoplasmic Ca2+ has a dual effect on NCX1 activities, and that allosteric Ca2+ activation of NCX1 can be opposed by the Ca2+-dependent long-term inactivation in intact cells.
Calcium
;
Capsaicin
;
Cytoplasm
;
Cytosol
6.Combination of a Rapidly Penetrating Agonist and a Slowly Penetrating Antagonist Affords Agonist Action of Limited Duration at the Cellular Level
Larry V PEARCE ; Jihyae ANN ; Peter M BLUMBERG ; Jeewoo LEE
Biomolecules & Therapeutics 2019;27(5):435-441
The capsaicin receptor TRPV1 (transient receptor potential vanilloid 1) has been an object of intense interest for pharmacological development on account of its critical role in nociception. In the course of structure activity analysis, it has become apparent that TRPV1 ligands may vary dramatically in the rates at which they interact with TRPV1, presumably reflecting differences in their abilities to penetrate into the cell. Using a fast penetrating agonist together with an excess of a slower penetrating antagonist, we find that we can induce an agonist response of limited duration and, moreover, the duration of the agonist response remains largely independent of the absolute dose of agonist, as long as the ratio of antagonist to agonist is held constant. This general approach for limiting agonist duration under conditions in which absolute agonist dose is variable should have more general applicability.
Capsaicin
;
Ligands
;
Nociception
7.Effects of Capsaicin Pretreatment on the Functions of Mouse Peritoneal Macrophages.
Jae Seung PARK ; Jeong Ho LEE ; Tai You HA
Korean Journal of Immunology 2000;22(1):39-49
No abstract available.
Animals
;
Capsaicin*
;
Macrophages, Peritoneal*
;
Mice*
8.The morphometric study of the effect of capsaicin on the spinal ganglion cells in neonatal rats.
Young Joo KIM ; Jong Eun LEE ; Kyung Ah PARK
Korean Journal of Anatomy 1991;24(3):316-329
No abstract available.
Animals
;
Capsaicin*
;
Ganglia, Spinal*
;
Rats*
9.Efficacy of capsaicin sensitive nerve on goblet cells and submucosal glands in rats.
Sang Hag LEE ; Heung Man LEE ; Keun JUNG ; Chung Sik CHOI ; Soon Jae HWANG
Korean Journal of Otolaryngology - Head and Neck Surgery 1993;36(2):264-273
No abstract available.
Animals
;
Capsaicin*
;
Goblet Cells*
;
Rats*
10.Effect of Topical Capsaicin in Chronic Low Back and Posterior Neck Pain.
Min Young KIM ; Young Moo NA ; Seoung Woong KANG ; Jae Ho MOON
Journal of the Korean Academy of Rehabilitation Medicine 1997;21(3):511-517
The purpose of this study was to evaluate the effectiveness of topically applied capsaicin cream for the treatment of chronic low back and posterior neck pain. Fourty-one patients with chronic low back or posterior neck pain of more than 6 months despite comprehensive management in our rehabilitation department were selected for this study. Of these subjects, a group of 21 patients used capsaicin cream, and the other 21 patients used NSAID gel as a control group. Pain intensities in both groups were measured with the visual analogue scale(VAS) before the treatment, 2 weeks and 5 weeks after the treatment. McGill Pain Questionnaire(MPQ) was used before and 5 weeks after the treatment. According to followed-up VAS, MPQ-number of words chosen, and MPQ-pain rating index, there was an evidence of effective pain relief by capsaicin cream for the low back and posterior neck pain 5 weeks after the treatment. We conclude that continuous use of capsaicin cream for 5 weeks can be beneficial for the chronic pain patients in relieving pain and subsequently helping their rehabilitation process.
Capsaicin*
;
Chronic Pain
;
Humans
;
Neck Pain*
;
Rehabilitation