1.Research advances in immune checkpoint inhibitor-related cholangitis
Yucheng HOU ; Hongqiang ZHAO ; Caoer DONG ; Guangdong WU ; Xuan TONG ; Ang LI ; Qian LU ; Hong CHEN ; Rui TANG
Journal of Clinical Hepatology 2023;39(2):463-468
Immune checkpoint inhibitors (ICIs) have ushered in a new era of tumor treatment; however, immunotherapy-related adverse events are critical issues that restrict the clinical application of ICIs and have attracted wide attention. The liver is one of the target organs that is easily affected. With the progress in research, scholars have found that besides hepatocytes, intrahepatic and extrahepatic bile ducts can also be attacked by the immune system, leading to the disease known as immune-related cholangitis. This article reviews the research advances in ICI-related cholangitis by summarizing related articles, in order to preliminarily reveal its clinical, pathological, and imaging features and provide clues for early identification, standard treatment, and subsequent research.
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