PURPOSE: To assess the utility of color Doppler sonography in the differential diagnosis of thyroid nodules. MATERIALS AND METHODS: Fifty patients with thyroid nodules(10 cases of follicular adenoma, 12 of adenomatous hyperplasia, 21 of papillary adenocarcinoma, and 7 of follicular adenocarcinoma) were analyzed. Colour signal analysis was performed by inspecting the signals in and around the nodules, and these were graded from 0 to III according to the degree of vascularity in internal and marginal blood flow. Peak systoic velocity (PSV) and resistive index (RI) in internal vascularity were used to analyse the flow signal. RESULTS: Internal colorsignals of malignant lesions tended to be high grade, whereas those of benign lesions tended to be low grade, with statistical significance(P<0.05). In spectral wave analysis, correlation between PSV and malignancy of thyroid nodules was statistically significant(P<0.05). The value of RI did not correlate with the malignancy of nodules, but tended to show a meaningful difference. CONCLUSIONS: Although further studies may be required, color Dopplersonography using color signal analysis and flow signals analysis is a useful imaging modality for the differentiation of benign and malignant lesions of thyroid nodules.
Adenocarcinoma, Papillary ; Adenoma ; Diagnosis, Differential ; Humans ; Thyroid Gland* ; Thyroid Nodule*

No abstract available.
Adenocarcinoma, Papillary*

BACKGROUND: Micropapillary Thyroid Cancer (MPTC) is defined as papillary thyroid cancer measuring less than one centimeter in size. Although there have been many studies involving MPTC, there is still a gap in the understanding of the behavior of MPTC in the Filipino population.

OBJECTIVES: This study aims to determine risk factors and prevalence of locoregional and distant metastasis upon diagnosis and the risk factors for persistent disease after thyroidectomy among patients with MPTC.

METHODS: This is a retrospective study that included all patients with histopathology result of MPTC from January 1, 2004 to December 31, 2012. Patients who had accompanying well differentiated thyroid tumors other than MPTC and those patients with a diagnosis of MPTC with no follow up after the surgery were excluded.

RESULTS: A total of 109 patients were eligible for the study. The mean age was 46.06 years with majority being female (96.3%). The average tumor size was 0.502 cm. Seventy-five  (68.81%) received Radioactive Iodine Therapy (RAI) after thyroidectomy. Nineteen patients (17.92%) had multifocal disease while 11 (10.09%) had multicentric disease. Fifteen patients (13.76%) had locoregional metastasis while eight (7.34%) had distant metastasis on diagnosis. Out of the 91 patients included for analysis of persistent disease, eight patients (8.79%) had persistent disease. Exact logistic regression showed that locoregional metastasis (p=0.0044) is a risk factor for distant metastasis at diagnosis. Age, sex, tumor size, multifocality, multicentricity, RAI, and extent of surgery did not reach statistical significance as independent risk factor for locoregional, distant metastasis on diagnosis, and persistent disease.

CONCLUSION: Although MPTC is considered an indolent type of well differentiated thyroid cancer, there are certain patients who may present with metastasis at diagnosis. Our data showed that locoregional metastasis is a risk factor for distant metastasis on diagnosis in patients having MPTC. 

Human ; Male ; Female ; Aged ; Middle Aged ; Adult ; Thyroidectomy ; Iodine ; Prevalence ; Thyroid Cancer, Papillary ; Thyroid Neoplasms ; Adenocarcinoma

Thyroid carcinoma is the most common endocrine maligancy, and the worldwide incidence has been rising in recent years. Differentiated thyroid carcinoma is the most common thyroid malignancy, which include thyroid papillary carcinoma and follicular thyroid carcinoma, accounting for about 90 percent of thyroid carcinoma incidence. Currently, surgical treatment, iodine radiotherapy and TSH suppressive therapy are the commonly accepted effective treatments for differentiated thyroid carcinoma, and most patients can be cured. But there are still some patients not sensitive to the general treatments, who have lost the treatment of opportunity. Molecular targeted therapy is an agonistic or suppressive treatment for molecular biology targets of malignant tumor, and currently is a frontier research in the field of malignancy treatment. By retrieving and analyzing the related literature of molecular targeted therapy of thyroid carcinoma through PUBMED in the past 5 years, the article introduced the current status of molecular targeted therapy of thyroid carcinoma.
Adenocarcinoma, Follicular ; drug therapy ; Carcinoma ; drug therapy ; Carcinoma, Papillary ; Humans ; Molecular Targeted Therapy ; Thyroid Cancer, Papillary ; Thyroid Neoplasms ; drug therapy

No abstract available.
Adenocarcinoma* ; Adenocarcinoma, Papillary ; Stomach

Endometrial papillary serous carcinoma (EPSC) is a distinct variant of endometrial adenocarcinoma that histologically resembles ovarian serous papillary adenocarcinoma and has an aggressive clinical course. Usually, the tumor is diagnosed at the advanced stage. The tumor has well confused with metastatic ovarian tumor of identical histology. Diagnosis of EPSC should be considered when the cervico-vaginal smear reveals numerous papillary clusters of tumor cells with macronucleoli and psammoma bodies. Recently, we have experienced two cases of EPSC diagnosed on cervico-vaginal smears, which revealed characteristic cytologic features including numerous papillary clusters of tumor cells with macronucleoli. The cytologic diagnoses were confirmed on histologic sections.
Adenocarcinoma ; Adenocarcinoma, Papillary ; Diagnosis

Adenocarcinoma, Follicular ; metabolism ; pathology ; Adenoma, Chromophobe ; metabolism ; pathology ; Adenoma, Oxyphilic ; metabolism ; pathology ; Angiomyoma ; metabolism ; pathology ; Biomarkers, Tumor ; metabolism ; Carcinoma, Papillary ; metabolism ; pathology ; Carcinoma, Renal Cell ; classification ; metabolism ; pathology ; ultrastructure ; Diagnosis, Differential ; Humans ; Kidney Neoplasms ; classification ; metabolism ; pathology ; ultrastructure ; Thyroid Neoplasms ; metabolism ; pathology

Biliary papillomatosis (BP) is an extremely rare condition that's characterized by multicenteric proliferations of adenomatous epithelium within the large bile ducts. Although BP is basically a collection of benign papillary adenoma, papillary adenocarcinoma can develop within these lesions, and it has a tendency to spread supericially along the bile duct mucosa. Such a malignancy is rare, but the prognosis is poor if it is impossible to completely remove the tumor. We report here on one case of multiple biliary papillomatosis in the biliary tree.
Adenocarcinoma, Papillary ; Adenoma ; Bile Ducts ; Biliary Tract ; Epithelium ; Mucous Membrane ; Papilloma* ; Prognosis

Familial adenomatous polyposis (FAP) includes early development of up to thousands of colorectal adenoma and of colonic adenocarcinoma in all untreated cases. Moreover, a variety of extracolonic manifestation are seen. Several reports have demontrated a high incidence of papillry carcinoma of thyroid. We experienced a case of familial adenomatous polyposis, presenting with thyoid papillry carcinoma, and reported with a brief review of literatures.
Adenocarcinoma ; Adenoma ; Adenomatous Polyposis Coli* ; Carcinoma, Papillary* ; Colon ; Incidence ; Thyroid Gland* ; Thyroid Neoplasms

No abstract available.
Adenocarcinoma, Papillary* ; Thyroid Gland*