The paper gives a comprehensive account of the evolution of the academic discipline of hospital administration and the training level as well as requirements of the discipline both at home and abroad. It puts forward the suggestion of strengthening the building of the setup of the discipline from the perspective of the systems of both internal and external administration. The paper focuses on the progress of research on the discipline, viz. the system of macro hospital administration and evidence based medicine have become the priorities of research on hospital administration and the attitude of individual oriented service and the concept of patient centered care have become the theme of such research. With the constant deepening of health reform and focusing on the achievement of the social goals of medical service, the academic discipline of hospital administration has formed the trends of moving from internal administration to external administration and from research on micromechanism to reform in the macro system.

In this study we found that while pituitrin induced a significant decline of nutritional blood flow of myocardium in mice, oxygen free radical concentration andmalondialdehyde content significantly increased, and superoxide dismutase activity signifi-cantly declined in the ischemic myocardium. These results suggest that this pituitrin-inducedmyocardial ischemia in mice may serve as an easy-to-operate, cheap and in vivo model forscreening oxy-radical scavengers in the study of anti-ischemic myocardial injury.

The paper first summarizes the major trends and chief features in the current development of imaging medicine and then by focusing on such characteristics of modern imaging medicine as a broad base of specialized knowledge, a wide disciplinary span and rapid equipment and technology development, it dwells on the importance of hospital managers doing a good job of personnel cultivation in modem imaging medicine in such aspects as the integration of medicine, engineering and technology, the combination of medicine, education and research, and the awareness of imaging in a larger sense.

ObjectiveTo investigate the efficacy and toxicity of docetaxel combined with compound tegafur capsule(S-1)on anthracycline-refractory recurrent metastatic breast cancer (ARMBC).Methods Thirty-eight ARMBC patients were given intravenous 70 mg/m2 docetaxel at day 1,and oral 60 mg/m2 S-1twice every day at day 1 to 14.Every 3 weeks was one cycle and each patient received at least two cycles.ResultsAfter treatment,among these 38 patients,there was 2 complete response (CR) (5.3 ％),20 partial response (PR) (52.6 ％),10 stable disease (SD) (26.3 ％),and 6 progressive disease (PD) (15.8 ％).Overall objective response rate was 57.9 ％ (95 ％ confidence intervaal: 42.6 ％-74.2 ％) while clinical benefit response rate was 73.7 ％ (95％ confidence interval: 58.4 ％-89.1％).The median time to progression (TTP) was 7.8 months(95 ％ confidence interval:6.7-8.9 months),and median overall survival time(OS)was 15.7 months (95 ％ confidence interval: 12.9-18.8 months).The main toxic reaction was myelosuppression,and grade Ⅲ and Ⅳ adverse events including leucopenia occurred in 21.1％ of all cases.Most common grade Ⅰ and Ⅱ adverse events,such as hand-foot syndrome,nausea,vomiting,diarrhea,liver dysfunction,and oral mucositis,were tolerable.ConclusionGood clinical efficacy is achieved in the therapy of metastatic breast cancer with docetaxel and S-1 combination regimen and toxic reaction is tolerable.

Objective To observe the effects of Danhong Injection in the treatment of lacunar cerebral infarction, Methods 82 patients with lacunar cerebral infarction were randomly recruited into a treatment group (n=42) and a control group (n=40). The treatment group was treated with Danhong Injection, 30ml/d for once, while the control group was treated with Danshen Injection, i.v. 20ml/day for once. Both groups were treated for 14 days. Results The total effective rate was 97.62% and 77.50% in the treatment group and the control group respectively, showing significant difference (χ~2=4.65, P< 0.05) . Conclusion Danhong Injection is better than Danshen Injection in treatment of lacunar cerebral infarction.

Objective To control the quality of Gongyankang granule.Methods Paconiflorin in Gongyankang granule was determined by HPLC,using a Phenomenex Prodigy Thermouest(250×4.6 mm 5μm BDS C18).Mobile phase was consisted of CH_2OH-H_2O-H_3PO_4(30:70:0.1)with the UV detector set at 230 nm.Results The paeoniflorin showed linear correlation(r=0.9998)within the range of 0.01026～0.06156mg.The average recovery rate was 99.12%with RSD of 1.61%.Conclusion This method was simple,accurate and with good reproducibility,thus it can be used for quality control of Gongyankang Granule.

Objective To explore the cause and treatment of chronic pain after tension-free repair of inguinal hernia.MethodsThe clinical data of 426 cases with inguinal hernia underwent the tension-free hernioplasty during February 2002 to September 2007 were retrospectively analyzed.ResultsTension-free hernioplasty was performed to all patients.According to operative methods,they were divided into two groups:polypropylene filling group(n=210)and expanded polytetrafluoroethylene(e-PTFE)mycromesh group(n=216).The chronic pain rate after operation,polypropylene filling group(9.0%,19/210)was significantly higher than e-PTFE mycromesh group(4.2%,9/216),P

Objective To study the effect of Simo Decoction on senile constipation. Methods A total of 109 cases with senile constipation were randomly recruited into a control group (49 case) and a treatment group (60 case). The control group was treated with Dangguihuilong pill, while the treatment group was additionally treated with Simo Decoction on that basis.Results The total effective rate was 93.33% and 79.59% in the treatment group and the control group respectively, showing statistical difference (x2=22.586, P＜0.01). Conclusion It was effective to treat senile constipation with Simo Decoction.

Objective To control the quality of GongYanKang Granule. Methods Radix Paeoniae Rubra, Corydalis and Radix Angelicae Sinensis of Gongyankang Granules were identified by TLC. Results Qualitative identification to Radix Paeoniae Rubra, Corydalis and Radix Angelicae Sinensis in GongYanKang Granules by TCL showed that this method has negative interference, clear spots and good resolving powder. Conclusion This method is simple and accurate with good reproducibiliy, being suitable for quality control of Gongyankang Granule.

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