In recent years, various studies and analyses related to cosmetics safety were conducted according to routine tests in Hygienic Standard of Cosmetics (2007), and the eligible rates of tested cosmetics were high. But the other prohibited and limited use components, such as antibiotics were analyzed rarely, and meanwhile some kinds of cosmetic related dermatitis cases appeared dramatically. Several dermatitis, especially contact dermatitis and hormone dependent dermatitis symptoms were not contained in Diagnostic Criteria and Principles of Management of Skin Diseases Induced by Cosmetics-General Guideline, GB 17149.1—1997. So it indicated the standard, GB 17149.1—1997 should be revised and some prohibited and limited use components such as hormone and antibiotic testing should be appended to the safety analysis of cosmetics.

Objective To explore the prenatal ultrasonic types ,sonographic features of malformation , ultrasonic diagnosis and prognosis of fetuses with adrenal area space‐occupying lesions . Methods Forty‐four fetuses with adrenal area space‐occupying lesions were retrospectively analyzed . Compared with postpartum neonatal special inspection results or the anatomical and pathological examination results of the corpses after induced labor ,the ultrasound types ,sonographic feature ,the key points of differential diagnosis were summarized . The newborns were followed up to 6 months after birth ,tracking the prognosis . Results Totally 44 fetuses among 166 471 fetuses(166 471 pregnant women) were detected with adrenal area space‐occupying lesions , 41 cases after delivery , including 24 cases adrenal hematoma ( 2 cases prenataly misdiagnosed as neuroblastoma) ,14 cases adrenal cyst and 3 cases neuroblastoma ,were accurately diagnosed through color Doppler or MRI or CT or pathological examination results . Three cases after induced labor , including 1 case adrenal neuroblastoma ,1 case mullerian duct cyst and 1 case adrenal hematoma( prenataly misdiagnosed as neuroblastoma ) were confirmed through the anatomical and pathological examination results of the corpses . So the conformity rate of adrenal area space‐occupying lesions was 90 .9% (40/44) . The postnatal ultrasound showed that the tumor disappeared in twenty‐four cases of adrenal hematoma without surgery ,and the longest time of the tumor disappearance was 1 year . The size of 14 cases adrenal cyst had no obvious change . One case of adrenal neuroblastoma was operated at 2 months ,2 cases were operated at 2 years of age . Conclusions Ultrasound can be used as qualitative diagnosis and differential diagnosis for fetal adrenal area space‐occupying lesions . The majority of the children with adrenal area space‐occupying lesions have a good prognosis .

AIM: To investigate the expression and effects of sialyl Lewis X (SLeX) on the invasion and migration of human hepatocellular carcinoma HepG2 cells.METHODS: The expression of α1,3-fucosyltransferase VII (FUT7) in HepG2 cells and L-02 cells was detected by RT-qPCR and Western blot.The SLeX expression in HepG2 cells and L-02 cells was determined by Western blot and immunocytochemical staining.The invasion and migration abilities of the treated cells were evaluated by Transwell assay.RESULTS: The expression of FUT7 and SLeX in the HepG2 cells, but not in the L-02 cells, was observed.The invasion rates of the HepG2 cells treated with SLeX monoclonal antibody at 0.05, 0.5 and 5 mg/L were significantly decreased as compared with control group (P<0.05).The migration ability of the HepG2 cells treated with SLeX monoclonal antibody at 0.05, 0.5 and 5 mg/L was also significantly reduced as compared with control group (P<0.05).The invasion rate and migratory cell number were significantly different between any 2 groups in the HepG2 cells treated with SLeX monoclonal antibody at 0.05, 0.5 and 5 mg/L (P<0.05).CONCLUSION: HepG2 cells express SLeX.SLeX is closely related to the migration and invasion abilities of the HepG2 cells.

The fast development of the molecular biology and the further research on the nucleic acid set a solid foundation for the development of genosensor.Genosensor is the result of combining molecular biology with microelectronics,electrochemistry,optics and etc,which will build a bridge between the life science and the information science and become one of the most important technologies for DNA information analysis and detection.The working principle,classification of genosenor and the recent research on its application in the detection of functional genes of environmental microorganisms are discussed according to the latest literature.And it is pointed out that the application in the determination of microorganism functional genes in compost is an important development orientation of genosensor.

Objective:To investigate efficacy before and after operation of Information-motivation-behavior nursing model in low-temperature plasma tonsillectomy.Methods:A total of 132 cases of tonsillectomy patients admitted to our department of otolaryngology from January 2016 to January 2017 were selected as research objects. All patients were divided into observation group and control group by random number table method, with 66 cases in each group. Cold plasma tonsillectomy was performed in both groups. The control group received routine nursing measures, and the observation group received IMB nursing mode based on the information - motivation - behavioral skills model. The psychological and emotional scores, surgical awareness, behavior and quality of life scores of patients in the two groups were compared.Results:There was no significant difference in Self-rating Anxiety Scale (SAS) and Self-rating Depression Scale (SDS) scores of patients in the observation and control groups before nursing, and SAS and SDS scores of patients in the observation group [SAS (40.56±2.12); SDS (40.56±2.12)] and control group [SAS (50.24±2.14); SDS (47.66±2.57)] were significantly decreased after 1 month of nursing ( t value was13.958, P=0.000), and there were statistically significant differences in the scores between two groups ( t value was 26.106, P=0.000). Before nursing, there was no statistically significant difference in surgical awareness between the two groups, and there was a significant difference in surgical awareness between the observation group (96.97%, 64/66) and control group (84.85%, 56/66) 1 month after nursing ( χ2 value was 16.810, P=0.000), and the observation group was higher than the control group. The scores of the observation group on regular work and rest, taking medicine on time, giving up smoking and drinking, healthy diet, and rehabilitation training (96.12±2.33, 95.72±2.16, 96.96±2.56, 95.68±2.14, 96.45±2.69) were higher than those of the control group (88.42±5.12, 89.86±5.33, 90.13±5.22, 87.61±5.36, 88.19±5.43). There was significant difference in those scores ( t value was 8.278-11.360, P=0.000). After 1 month of nursing, SF-36 scores of patients in the observation group (86.47±6.99) were significantly higher than those in the control group (74.28±7.23) and the difference was statistically significant ( t value was 9.848, P=0.000). Conclusions:Information - motivation - behavior nursing model is helpful to improve the psychological state of patients before and after low-temperature plasma tonsillectomy, and improve the patients′ awareness of the operation and quality of life.

Objective To investigate the possible reasons and the treating expefiences of ophthalmic complications in order to elevate the attention of the nasal endoscopic surgeon.Methods This study was involved 8 categories in 22 cases which had typical characteristic of ophthalmic complications of endoscopic sinus surgery,including injury of lamina papyracea,obstructive cyst of frontal and ethmoid sinuses,orbital infection,injuries of lacrimal passages,injury of extraocular muscles,orbital hemorrhage,optic nerve injury and arterial embolism of optic fundi.The patients were given corresponding treatment.Results Injury of lamina papyracea Was cured by medical treatment while orbital infection,injury of lacrimal passages,obstructive cyst of frontal and ethmoid sinuses were completely recovered by endoscopic surgery.In one of the cases,the injured optic nerve had recovered after transnasal optic and orbital apex decompression but the other 6 sides of 6 patients had not been improved.In one case who had suffered from injury of extraocular muscles,their diplopia isappeared mostly.but the other cases had a slight diplopia after surgery.One case who had visual descending caused by orbital hemorrhage recovered.Two cases of visual loss caused by intraorbital hemorrhage and arterial embolism of optic fundi respectively were not improved. Conclusions It is very difficult to cure if the patients lose the sight because of optic nerve injury,orbital hemorrhage and the ischemia of orbit,however.if the patients had remnant vision the prognosis should be much better.

Objective To understand the readiness of gynecological wards in conducting the evidence-based practice for the prevention and management of urinary retention after cervical cancer radical resection,and to analyze the influencing factors.Methods The 190 nursing staffs in the gynecological oncology wards of this hospital in June 2020 were selected as the study subjects.The assessment of readiness for evidence-based nursing practice (CREBNA) and general information questionnaire were used to conduct the questionnaire survey,single factor and multiple factor stepwise regression to analyze the influencing factors.Results The score of CREBNA was (135.94±17.83) points,the evidence subscale was (52.41±7.88) points,the organi-zational environment subscale was (40.58±5.01) points and the promoting factors subscale was (42.67±6.24) points.The results of univariate analysis showed that the total score of CREBNA was related to the ed-ucational background,professional title,position,scientific research experience,understand degree on evidence-based and necessity of conducting evidence-based (P<0.05).The multiple stepwise regression analysis showed that the understanding degree on the evidenced-base and necessity of conducting evidence-based were the influencing factors of CREBNA scale (P<0.05).Conclusion The readiness of the evidence-based nursing practice in this study is good and has good feasibility.

Anxiety/epidemiology* ; Depression/epidemiology* ; Humans ; Sleep ; Sleep Quality ; Students ; Surveys and Questionnaires ; Universities