No abstract available.
Caloric Restriction ; Intra-Abdominal Fat ; Muscles

No abstract available.
Caloric Restriction ; Intra-Abdominal Fat ; Muscles

BACKGROUND: The relation of initial depression and weight loss in a low calorie diet(LCD) alone or exercise combination in Korean wamen, was considered and change of emotional state after program was determined in this study. METHODS: Sixty obese females were randomly prescribed a LCD(low calorie diet) alone or a LCD with exercise. Thirty obese females were treated with a LCD of 1,000kcal/d for 8weeks(group A). Another thirtyt obese females were treated with a LCD of 1,000kcal/d combined with supervised aerobic exercise for 8 weeks(group B). Questionnaires including Korean-translated Beck Depression Inventory(BDI), Korean- translated Brief Encounter Psychosocial Instrument(BEPSI) were reported before and after 8weeks fo this study. RESULTS: 21 out of 30 obese females in group A and 25 out of 30 obese females in group B completed the study. At the eighth week, mean weight loss was 5.7+/-2.2kg(8.0%) in group A, and 6.8+/-1.7kg(9.5%) in group B. Depression were decreased after program(decreased BDI score in combined group(6.86+/-6.31: p = 0.0001), group A(5.79+/-4.06:p=0.0001) and group B(7.68+/-7.58:p=0.0001), but no statistically significant difference between group A and B was noted(p=0.3309). Initial BDI score was negatively correlated with the percent of weight loss in group A(r =-0.659: p=0.0012). But initial BDI score was not correlated with the percent of weight loss in group B(r =0.099: p=0.637). In group A and B, the percent of weight loss was not correlated with change of BDI score. In group A and B, the change of BDI score was positively correlated with the initial BDI score(group A;r=0.504:p=0.028, group B;r=0.762:p=0.0001). CONCLUSIONS: Regardless of the exercise combination, LCD therapy seemed to decrease diepression. The degree of weight loss was negatively correlated with initial degree of depression. this negative correlation can be compensated by planned thorough exercise.
Caloric Restriction* ; Depression* ; Exercise ; Female ; Humans ; Weight Loss* ; Surveys and Questionnaires

Caloric restriction (CR) is explored to limit the caloric intake without malnutrition. CR can affect the levels of various metabolites in organism, such as lipids, free fatty acids, ketones, bile acids and amino acids, etc, and is thought being able to extend the lifespan, postpone and reduce the incidence of age-related disorders (e.g., type 2 diabetes, cancer and cardiovascular diseases). These effects are mainly attributed to the role of CR in energy metabolism. The mechanism of CR on energy metabolism is closely related to biological clock, hormonal production, gastrointestinal flora and inflammation. Here we briefly review the effects and mechanism of CR on energy metabolism.
Caloric Restriction ; Diabetes Mellitus, Type 2 ; Energy Metabolism ; Humans ; Longevity

The silent information regulator protein 2 (Sir2) and its homologues play an important role in the regulation of cellular physiological processes such as survival, apoptosis, and aging. SIRT1, the mammalian Sir 2 homologue, has been shown to deacetylate a wide range of non-histone substrates and histone substrates. It has been constantly reported that SIRT1 may be associated with the occurrence of metabolic syndrome, genomic homeostasis, tumors, and neurodegenerative diseases. Calorie restriction may mitigate many major diseases in rodent models by SIRT1-mediated deacetylase activity and prolong the life expectancies in these animals. Therefore, SIRT1 may be emphasized as a new therapy target for many different diseases.
Animals ; Caloric Restriction ; Humans ; Longevity ; Sirtuin 1 ; genetics ; physiology ; Substrate Specificity

Ageing is the most significant risk factor for a range of prevalent diseases, including cancer, cardiovascular disease, and diabetes. Accordingly, interventions are needed for delaying or preventing disorders associated with the ageing process, i.e., promotion of healthy ageing. Calorie restriction is the only nongenetic and the most robust approach to slow the process of ageing in evolutionarily divergent species, ranging from yeasts, worms, and flies to mammals. Although it has been known for more than 80 years that calorie restriction increases lifespan, a mechanistic understanding of this phenomenon remains elusive. Yeast silent information regulator 2 (Sir2), the founding member of the sirtuin family of protein deacetylases, and its mammalian homologue Sir2-like protein 1 (SIRT1), have been suggested to promote survival and longevity of organisms. SIRT1 exerts protective effects against a number of age-associated disorders. Caloric restriction increases both Sir2 and SIRT1 activity. This review focuses on the mechanistic insights between caloric restriction and Sir2/SIRT1 activation. A number of molecular links, including nicotinamide adenine dinucleotide, nicotinamide, biotin, and related metabolites, are suggested to be the most important conduits mediating caloric restriction-induced Sir2/SIRT1 activation and lifespan extension.
Biotin ; Caloric Restriction* ; Cardiovascular Diseases ; Diptera ; Humans ; Longevity ; Mammals ; NAD ; Negotiating ; Niacinamide ; Risk Factors ; Sirtuins ; Yeasts

The sirtuins (SIRTs) are protein-modifying enzymes that are distributed ubiquitously in all organisms. SIRT1 is a mammalian homologue of yeast nicotinamide-adenine-dinucleotide-dependent deacetylase silent information regulator 2 (known as Sir2), which is the best-characterized SIRT family member. It regulates longevity in several model organisms and is involved in several processes in mammalian cells including cell survival, differentiation, and metabolism. SIRT1 induction, either by SIRT-activating compounds such as resveratrol, or metabolic conditioning associated with caloric restriction, could have neuroprotective qualities and thus delay the neurodegenerative process, thereby promoting longevity. However, the precise mechanistic liaison between the activation of SIRT and extended healthy aging or delaying age-related diseases in humans has yet to be established.
Aging ; Caloric Restriction ; Cell Survival ; Humans ; Longevity ; Neurodegenerative Diseases ; Sirtuins ; Stilbenes ; Yeasts

Numerous studies have established a link between autophagy and aging; however, the relationship has not been clearly defined. Aging is a very complex process caused by the accumulation of various factors due to the gradual failure of cellular maintenance. Recent studies have shown that autophagy reduces the stress responses induced by starvation, reactive oxygen species, and the accumulation of intracellular proteins and organelles through cytoprotection, clearance of damaged mitochondria, and lysosomal degradation. Here, we summarize our current understanding of the relationship between autophagy and the aging process.
Aging* ; Autophagy* ; Caloric Restriction ; Cytoprotection ; Mitochondria ; Organelles ; Proteins ; Reactive Oxygen Species ; Starvation

Numerous studies have established a link between autophagy and aging; however, the relationship has not been clearly defined. Aging is a very complex process caused by the accumulation of various factors due to the gradual failure of cellular maintenance. Recent studies have shown that autophagy reduces the stress responses induced by starvation, reactive oxygen species, and the accumulation of intracellular proteins and organelles through cytoprotection, clearance of damaged mitochondria, and lysosomal degradation. Here, we summarize our current understanding of the relationship between autophagy and the aging process.
Aging* ; Autophagy* ; Caloric Restriction ; Cytoprotection ; Mitochondria ; Organelles ; Proteins ; Reactive Oxygen Species ; Starvation

This study was performed in order to compare the differences in dietary self-efficacy and eating behaviors as well as the relationship of weight control attitudes according to eating disorder perception and obesity index for high school girls majoring in dance. Almost half (45.5%) of the subjects perceived eating disorders, and the rate of underweight group was 45.7%. Forty-four percent of the group that perceived eating disorders were in modern dance, while 55.0% of the group that did not perceived eating disorders were in Korean dance (P <0.05). For the obesity index, a similar rate was shown between the different types of dance for the underweight group, but in the normal group, 54.5% were in Korean dance (P <0.05). Most (82.0%) of the group that perceived eating disorders had fears on obesity, while only 53.3% of the non-perceiving group had fears on obesity (P <0.01). Over half (58.3%) of the underweight group had fears on obesity, while 77.2% of the normal group showed fear in that (P <0.05). For necessity of weight loss to do dance performances, 25.0% of the underweight group and 57.9% of the normal group need that (P <0.05). Most of the group that perceived eating disorders (92.0%) answered that they had experience in very low calorie diets, while only 40.0% of the non-perceiving group had experience (P <0.001). For necessity of calorie education, 42.0% of the group that perceived eating disorders and only 20.0% of the non-perceiving group answered is needed (P <0.05). For eating behavior , the group that perceived eating disorders had lower total scores compared to the non-perceiving group (P <0.001), The group that perceived eating disorders showed lower scores for restraint eating (P <0.01) and emotional factors (P <0.001) except by external eating. This study showed that high school girls majoring in dance have high interest in weight control and problems with wrongful body images and eating behaviors, as well as need for calorie education were suggested. Thus, it is necessary to develop and execute a proper weight control education program for the subjects.
Body Image ; Caloric Restriction ; Dancing ; Eating ; Feeding and Eating Disorders ; Feeding Behavior ; Humans ; Obesity ; Thinness ; Weight Loss