1.Changes of cellular immunity in patients with hypertrophic sear
Xihua WANG ; Jun WU ; Caizhi GU
Chinese Journal of Medical Aesthetics and Cosmetology 2001;0(03):-
Objective To analyse the changes of T lymphocytes and its subset in patients with scar hypertrophy. Methods In 6 keloid, 14 hypertrophic scar patients and 10 normal control, peripheral blood T lymphocytes (PBTL) and its subset were analysed with flow cytometry (FCM). Lymphocytic proliferation responsed to Con A stimulation in vitro lymphocytic culture system were performed and lymphocytic proliferation activity were assayed by the measurement of 3H TdR incorporation. Results The percent of CD3 +,CD4 +,CD8 + and ratio of CD4 +/CD8 + in PBTL of keloid patients were 78.6 %, 49.7 %, 23.5 % and 2.4, and in hypertrophic scar patients group were 68.9 %, 47.6 %, 26.6 % and 2.2, in normal control group were 69.2 %, 37.2 %, 30.9 % and 1.9, respectively. Lymphocytic proliferation activity expressed as proliferation stimulation index were 17.4,15.9 and 8.7 respectively in keloid, hypertrophic scar and normal group. The level of CD4 +?CD4 +/CD8 + and lymphocytic proliferation stimulative index were all significantly higher in both keloid and hypertrophic scar patients than that in normal control. Conclusion Aberrant immunologic function may play an important role in the pathogenesis of scar.
2.Relationship between college students’ perceived stress and their suicidal ideation: multiple mediating effect of resilience and depression
Caizhi WU ; Na MA ; Tingting HUANG ; Afang LU ; Zhihong REN ; Fenghui YUAN
Journal of Xi'an Jiaotong University(Medical Sciences) 2024;45(3):371-375
【Objective】 To explore the relationship between perceived stress and suicidal ideation as well as the mediating effect of resilience and depression. 【Methods】 A sample of 875 college students was recruited for the study to complete a set of self-report measures of Chinese Perceived Stress Scale (CPSS), the Resiliency Scale of University Students, Suicidal Ideation Questionnaire, and Beck Depression Inventory (BDI). 【Results】 ①College students’ perceived stress and depression had significantly positive correlation with their suicidal ideation, while the students’ resilience had a significantly negative correlation with their perceived stress and depression. ②Perceived stress did not affect suicidal ideation of the college students directly, but indirectly affected their suicidal ideation through three significant mediating pathways: the separate mediating effects of (a) resilience and (b) depression, and the serial mediating effect of (c) resilience and depression. 【Conclusion】 Resilience and depression exert a chain mediating effect between perceived stress and suicidal ideation of college students.
3.Reliability,validity, and cut-off score of the Chinese version of the Suicidal Behaviors Questionnaire-Revised
Caizhi WU ; Xin BAI ; Xueyu PENG ; Lixia YU ; Zhihong REN
Journal of Xi'an Jiaotong University(Medical Sciences) 2024;45(3):366-370
【Objective】 To examine the reliability and validity of the Suicidal Behaviors Questionnaire-Revised (SBQ-R) among Chinese undergraduates and to find out cut-off score for screening the risk of suicide in clinical undergraduates. 【Methods】 A total of 488 Chinese undergraduates participated in this study. Of them, 366 participants were asked to complete the Chinese version of SBQ-R, Psychache Scale, and Satisfaction with Life Scale. And 45 undergraduates were re-tested after four weeks; 122 undergraduates were tested by using the Suicidality Module Section of the Mini International Neuropsychiatric Interview and the Chinese version of SBQ-R. 【Results】 ① The results showed that The Chinese version of SBQ-R had one factor with good fit indices. ② The internal consistency reliability, split-half reliability, and one-month retest reliability of the total questionnaire were 0.76, 0.79, and 0.93, respectively. ③The total score of the SBQ-R in Chinese was positively correlated with psychache but negatively correlated with satisfaction of life, indicating that the scale has good criterion-related validity. ④ Receiver operating characteristics (ROC) curve evaluation suggested that the cut-off score was 9 in terms of identifying the clinical undergraduates at high risk of suicide. 【Conclusion】 SBQ-R is a reliable, valid, and practical instrument to measure the risk of suicide among Chinese undergraduates. SBQ-R>9 is the best cut-off value for screening for high suicide risk in China.
4.Reliability and validity of the Chinese version of the Social Connectedness Scale
Caizhi WU ; Ting WANG ; Wenting DUAN ; Weixin WANG ; Qiwu SUN
Journal of Xi'an Jiaotong University(Medical Sciences) 2022;43(4):496-502
【Objective】 To revise the Social Connectedness Scale-Revised (SCS-R) so as to explore the factor structure of SCS-R in the context of Chinese culture and test its reliability and validity. 【Methods】 Totally 900 college students were asked to complete the Chinese version of the Social Connectedness, and 850 valid questionnaires were collected. In addition, the Distress Disclosure scale (DDI) and UCLA Loneliness Scale were used as the criteria. One month later, 100 students were randomly selected for retest. 【Results】 ① The results of exploratory factor analysis showed that one factor with more than one eigenvalue was selected, and the cumulative variance explained was 62.44%. ② Confirmatory factor analysis showed that the data fit well (χ2=33.438, df=14, χ2/df=2.388, RMSEA=0.04, CFI=0.996, TLI=0.991). ③ The Chinese version of the social connectedness scale is a one-dimensional scale. Its internal consistency coefficient is 0.916 and test-retest reliability is 0.845. ④ Social connectedness is significantly positively correlated with distress disclosure and negatively correlated with loneliness, indicating that the scale has good criterion-related validity. 【Conclusion】 The Chinese version of the social connectedness scale has satisfactory reliability and validity, and has cross-cultural adaptability.