1.Advancement of pharmacokinetic studies on chinese herbal medicine-syn-thetic drug interactions
Jiangfei CHEN ; Jianyi HU ; Caiyun MIAO ;
Chinese Journal of Clinical Pharmacology and Therapeutics 2004;0(12):-
Traditional Chinese herbal medicines have been used for treating various ailments since medicine be- gan.The belief that natural products are much safer than synthetic drugs has led to dramatic growth of herbal medi- cine usage.Like synthetic drugs,herbal preparations also have potential to cause adverse effects and drug interac- tions.In this paper,pharmacokinetic studies on herb- drug interactions are reviewed and discussed in order to promote usage of herbs rationally and safely.
2.Analysis of risk factors of cerebral infarction in young adults and its correlation with TOAST types
Caiyun CHEN ; Chunling MA ; Jing TANG
Chinese Journal of Primary Medicine and Pharmacy 2017;24(4):582-585
Objective To explore the risk factors of youth cerebral infarction and its correlation with clinical TOAST types.Methods 82 young patients with acute cerebral infarction(aged from 18 to 45 years old)were select-ed.The risk factors for youth cerebral infarction patients,and the proportion of TOAST subtype and related risk factors were analyzed.Results Risk factors for youth cerebral infarction were as follows:hyperlipidemia (χ2 =48.703,P <0.05),hypertension (χ2 =40.829,P <0.05),carotid sclerosis (χ2 =46.217,P <0.05),hyperhomocysteinemia (χ2 =40.255,P <0.05),smoking history (χ2 =7.853,P <0.05),diabetes (χ2 =18.256,P <0.05)and family history (χ2 =5.944,P <0.05),heart disease (χ2 =5.754,P <0.05).The proportion of their TOAST subtypes were as following:small artery occlusion lacunar(SAD)(39.0%),large artery atherosclerosis(LAA)(24.4%),stroke of other undetemined etiology(SUE)(17.0%),and acute stroke of other detemined etiology(SOE)(12.2%),cardio-embolism(CE)type(7.3%).Major risk factors for LAA subtype included hyperlipidemia,hypertension and carotid atherosclerosis;Major risk factor for SUE subtype was hyperhomocysteinemia;Major risk factors for SOE included hypertension,diabetes.Major risk factor for CE subtype was heart disease.Conclusion The highest proportion of TOAST types in youth cerebral infarction group is small artery occlusion lacunar.Major risk factors for this group of youth cerebral infarction are as follows:hypertension,carotid atherosclerosis,heart disease,diabetes,hyperhomocys-teinemia,obesity,smoking and family history,and these risk factors should be actively intervened.
3.Study on chronotropic response in coronary disease with percutaneous coronary intervention
Zujin LIN ; Haipeng CAI ; Caiyun WU ; Jiang CHEN ; Hongwei PAN
Journal of Chinese Physician 2014;(4):471-474
Objecitve To investigate the changes of chronotropic response before and after percutaneous coronary intervention ( PCI)in patients with coronary disease .Methods A total of 339 patients with coronary disease was included in this study .All sub-jects underwent treadmill exercise test and coronary angiogram , and some patients underwent PCI if necessary .The parameters of chro-notropic response were recorded and analyzed , including ratio of the highest to predicted heart rates ( rHR) ,chronotropic response in-dex ( CRI) , and heart rate reserve ( HRR) .After coronary angiogram , the score of gensin was recorded and analyzed .Results There was significant difference in the parameter of CRI between unstable angina pectoris and silent myocardial ischemia groups ( P <0.05 ) , CRI were 0.80 ±0.11 and 0.89 ±0.07 , respectively .After coronary angiogram and PCI , there were significant differences in the parameters of rHR, CRI, and HRR between pre-therapy and post-treatment ( t =2.440, 1.977, 2.529, all P <0.05).A nega-tive correlation was found between the parameters of rHR , CRI, and HRR and the score of Gensin ( r =-0.686 , -0.673 , and-0.672, all P <0.05).The significant difference in rHR, CRI, and HRR existed between the groups of <20 and >40 ( t =2.567, 2.223, 2.062, all P <0.05).Conclusions Parameters (rHR, CRI, and HRR) had important clinical values in evaluating the changes of chronotropic response before and after PCI in patients with coronary disease with a negative correlation with the score of Gensin.
4.Content Determination of Zolpidem Tartrate in Microsamples of Rat Plasma by HPLC-fluorescence Method
Caiyun MIAO ; Jiangfei CHEN ; Suyan ZHU ; Ping XU
China Pharmacy 2016;(4):468-469
OBJECTIVE:To establish a method for the content determination of zolpidem tartrate in microsamples of rat plas-ma. METHODS:Rats were given zolpidem tartrate solution 3 mg/kg intragastrically,and 0.2 ml blood sample were collected and isolated. 50 μl plasma was precipitated by methanol,and the supernatant was determined by HPLC-fluorescence combined with ex-ternal method. Agilent HC-C18 column was used with mobile phase consisted of 0.03 mol/L KH2PO4 solution(containing 0.2% tri-ethylamine)-methanol (33∶67,V/V) at flow rate of 1.0 ml/min. The excitation and emission wavelengths were 254 nm and 390 nm,respectively. The sample size was 20 μl. RESULTS:The linear ranges of zolpidem tartrate in plasma was 2-200 μg/L(r=0.999 7),and the limit of quantification was 2 μg/L. The method recoveries of zolpidem were (96.96 ± 1.35)%-(105.0 ± 5.36)%(RSD=2.20%-4.88%,n=5),and extraction recoveries were (79.72 ± 0.01)%-(80.77 ± 0.02)%(RSD=1.34%-3.90%,n=5). The intra-day and inter-day RSDs were 1.40%-5.10% and 3.22%-9.25%(n=5),respectively. CONCLUSIONS:The method is simple,sensitive and suitable for the content determination of zolpidem tartrate in microsamples of plasma.
5.Analysis of the Costs of Various Drugs Consumed in 36 Hospitals of Guangzhou in the Years 1997~2000
Qinghuan WU ; Xizhou XIAO ; Lingyan MA ; Caiyun CHEN
China Pharmacy 1991;0(05):-
OBJECTIVE:To analyze the trend of costs of various drugs consumed in hospitals of Guangzhou METHODS:The data were derived from the Hospital Purchasing of Drug Information System in Guangzhou from 1997 to 2000 The expense of each drug was calculated at the price of that year RESULTS:The annual increasing rates of drug expenses in 1998,1999 and 2000 were 17 01%,24 49%,23 11% respectively CONCLUSION:It is a matter of great urgency to rationally use drugs,to eliminate the waste of resources and to lighten the patients'burden
6.Application of Ultrasound Guided Drainage Combined with Different Hardeners for Treatment of Simple Breast Cysts
Weilan LI ; Caiyun CHEN ; Ying LUO ; Guoquan LAO ; Haichun ZHANG
Chinese Journal of Medical Imaging 2016;24(12):903-905
Purpose To investigate the clinical effect of ultrasound guided drainage combined with different hardeners for simple breast cysts,and to further provide reference for individual treatment.Materials and Methods Clinical data of 117 cases breast simple cysts were analyzed retrospectively,of which 42 cases were routine ultrasound-guided puncture combined with fluid injection of hypertonic sugar (group A),40 cases were routine ultrasound guided drainage combined with ethanol injection therapy (group B),and 35 cases were routine ultrasound guided therapy alone (control group).The clinical efficacy and adverse reactions were compared among the three groups after treatment.Results The total effective rate of group A was 95.24%,group B was 97.50%,and control group was 82.86%.Total effective rate of group A and B had no significant difference (P>0.05),which were both higher than control group (P<0.05).The adverse reactions rate of group B was higher than group A and control group,which had statistical significance (P<0.05).Conclusion Ultrasound guided injection of hypertonic sugar or ethanol after drainage treatment for simple breast cysts can both obtain satisfactory clinical results,but adverse reactions of the former one are mild,it should be widely applied.
7.Analysis of the Costs of Various Drugs Consumed in 36 Hospitals of Guangzhou in the Years 1997~ 2000
Qinghuan WU ; Xizhou XIAO ; Lingyan MA ; Caiyun CHEN
China Pharmacy 2001;12(5):285-286
OBJECTIVE: To analyze the trend of costs of various drugs consumed in hospitals of Guangzhou METHODS: The data were derived from the Hospital Purchasing of Drug Information System in Guangzhou from 1997 to 2000 The expense of each drug was calculated at the price of that year RESULTS: The annual increasing rates of drug expenses in 1998, 1999 and 2000 were 17 01% , 24 49% , 23 11% respectively CONCLUSION: It is a matter of great urgency to rationally use drugs, to eliminate the waste of resources and to lighten the patients'burden
8.Preliminary study on the relationship between tubal intraepithelial carcinoma of the fimbria and pelvic high-grade serous carcinoma
Yun LIANG ; Xiaoduan CHEN ; Bingjian Lü ; Caiyun ZHOU ; Xiaofei ZHANG ; Haiyan SHI
Chinese Journal of Obstetrics and Gynecology 2011;46(10):724-728
Objective To explore the relationship between tubal intraepithelial carcinoma (TIC) of the fimbria and pelvic high-grade serous carcinoma.Methods All 34 cases of pelvic high-grade serous carcinoma with clear fimbria were evaluated from January 2009 to June 2010,including ovarian carcinoma (n=26),tubal carcinoma (n=7) and peritoneal carcinoma (n=1).Among of these ovarian carcinomas,12 cases were surface deposits and the other 14 cases within ovarian parenchyma.All 42 cases of non highgrade serous carcinoma in this period including 13 endometrioid ovary carcinomas,11 clear cell ovary carcinomas,11 mucinous ovary carcinomas,6 low-grade serous ovary carcinomas,1 low-grade serous tubal carcinoma,were also collected as a reference.The presence of tubal intraepithelial carcinomas was assessed.Based on the presence of TIC,high-grade serous ovary carcinomas were divided into TIC positive (+) and TIC negative (-) groups,and the clinical and pathological features of them were also evaluated.Results Fifteen cases (44%) were identified TIC in 34 high-grade pelvic serous carcinomas,and all of them were in the fimbria only,while none of TIC was found in control cases.There were significant difference between the two groups (x2=23.086,P=0.000).Eleven cases(42%) were identified TIC in all 26 high-grade ovarian serous carcinomas,in which 8 cases with unilateral ovary carcinomas were associated with ipsilateral TIC,2 cases with bilateral ovary carcinomas associated with unilateral TIC and one case with bilateral ovary carcinoma was associated with bilateral TIC.Four TIC (4/7) were identified in 7 cases with high-grade tubal serous carcinomas,and there was no presence of TIC in the 1 high-grade serous peritoneal carcinoma.Of all 26 high-grade ovarian serous carcinomas,6/11 cases were surface deposits,and 5/11 were parenchyma tumors in TIC (+) group while 6/15 cases were surface deposits and 9/15 were parenchyma tumors in TIC (-) group,in which there were correlated in distribution of TIC between the two groups( P>0.05 ).The average diameter of ovarian cancer were 6.9 and 6.5 cm between the two groups with no significant differences ( t=0.409,P=0.690).Conclusion TIC is specific to high-grade serous carcinomas and maybe have something to do with the pathogenesis of pelvic serous carcinomas.
9.Discussion on the management practice of focus drugs in Ningbo
Caiyun MIAO ; Jiangfei CHEN ; Jianwei XU
Chinese Journal of Hospital Administration 2019;35(7):576-578
This paper introduced the management of focus drugs in Ningbo, and evaluated the preliminary results by comparing the changes in terms of the income of these drugs before and after the measures taken. More measures should be taken by establishing a unified drug catalogue, strengthening the assessment, carrying prescription comment and periodic notification. The pharmacists can play a leading role in clinical rational drug use. These efforts can serve for scientific control of the unreasonable growth of medical expenses.
10.Reconstruction of failed urethroplasty with different tissues and materials for hypospadias
Jinchun QI ; Wenyong XUE ; Xiaolu WANG ; Lei DU ; Jianghua JIA ; Junxiao CHEN ; Xiuhong YANG ; Caiyun YANG
Chinese Journal of Urology 2014;(7):528-530
Objective To study the efficacy and complications of reconstruction of failed urethro-plasty for hypospadias with pedicle flap , bladder mucosa , buccal mucosa , and biological patch . Methods 23 patients were enrolled from Jul .2005 to Dec.2011.8 patients, with good local skin condition , were performed with pedicle flap urethroplasty .The other 15 patients, with bad local skin condition or with long segment urethral stricture , were performed with free grafts , including 6 bladder mucosa , 7 buccal muco-sal and 2 biological patch. Results Of the 23 cases, 7 cases were cured by one phase operation .There were 16 (16/25) cases had complications.3 (3/16) cases were failed because of serious infection (2 pedi-cle flap, 1 bladder mucosa ) .The failed cases were implemented with urethroplasty 6 months later by the buccal mucosa installments operation .4 (4/16) cases had solitary urethral fistula (1 pedicle flap, 2 bladder mucosa, and 1 buccal mucosal), who were successfully treated with simple fistula repair 3 to 6 months later. 9 ( 9/16) cases had urethral stricture ( 2 pedicle flap , 3 bladder mucosa , 3 buccal mucosal , and 1 biologi-cal patch graft ) , who were treated with urethral sound and got good result .We had reconstructed the urethra using mucosa graft onlay urethroplasty .All of the 23 patients were followed up with an average of 14.5 ( 6-24) months.23 cases were satisfied with the stretched penis , urination and no need to expand the urethra more than 6 months.3 cases were not satisfied with penile appearance .After communication, these patients did not require a further penis orthopedic surgery . Conclusions Pedicle flap, bladder mucosa , buccal mucosa and biological patch can be used in urethral repair and construction of failed urethroplasty for hypos -padias.Urethral sound dilation plays an important role in hypospadias repair .