Objective To understand the mental authorization status and job burnout for domestic nursesandanalyze the correlation between them, and to explore new strategies to prevent and reduce nurse job burnout.Methods There were 203 clinical nursesinvolved, who were chosen from 5 first-class leveltop first class hospitals in Guangzhou, using mental authorized scale and job burnout scale questionnaires made by ourselves to investigate the basic information, psychological empowerment and job burnout.Results Perception of nurses’ mental authorizationachieved (4.75 ±0.67) (the medium level), while self-efficacy acquired the highest score (5.34 ±0.73) compared work effectiongained the lowest one (3.64 ±0.11).The nurses had suffered severe burnout, which performed asloss of personal accomplishment dimension (3.83 ±0.62), emotional exhaustion dimension (2.96 ±0.81) and depersonalization tendency dimensions (1.89 ±0.84);nurses perceived psychological empowerment and job burnout had negative correlation with emotional exhaustion, depersonalization tendencies, personal accomplishment dimension ( r = -0.436, -0.366, 0.514, respectively;P<0.01).Working influence had less correlation with job burnout dimensions, especially with the dimension of depersonalization work and job burnout dimensions affect the correlation was not obvious, especially with the tendency to personify no correlation dimension (r=-0.094,P>0.05).Conclusions The mental authorizationof clinical nurses just acquires middle level;hence, clinical nursing managers should enhance nurse's mental authorizationto release job burnout.