Objective To analyze the current status and influencing factors of demoralization syndrome in patients with liver cirrhosis at the decompensated stage. Methods A total of 444 patients with liver cirrhosis at the decompensated stage were selected as study subjects from four tertiary hospitals in Changsha, Hunan Province using a convenient sampling method. The survey was conducted using a general information questionnaire, the Chinese version of the Demoralization Scale, the Social Support Rating Scale, the Chinese version of the Brief Illness Perception Questionnaire, and the Simplified Coping Style Questionnaire. Results The incidence of demoralization syndrome in patients with liver cirrhosis at the decompensated stage was 71.62%, with a mean total score of (38.21±14.34) for the Demoralization Scale. Multiple linear regression analysis showed that primary disease, the number of complications, Child-Pugh classification, coping style, illness perception, and social support were influencing factors of demoralization syndrome in patients with liver cirrhosis at the decompensated stage (P < 0.05). Conclusion The demoralization syndrome in patients with decompensated cirrhosis is at a severe level, and its main influencing factors are primary disease, the number of complications, Child-Pugh classification, social support, illness perception, and coping style. Healthcare professionals should regularly assess the level of demoralization syndrome in patients with liver cirrhosis at decompensated stage and adopt targeted interventions to improve their psychological status.