Purpose/Significance The recent applications of machine learning in epilepsy seizure prediction,diagnosis prediction,seizure detection,efficacy prediction of antiepileptic drugs,and epilepsy surgery prediction are summarized and analyzed.Method/Processs Literatures are searched through PubMed to summarize the performance of each machine learning model and the challenges exist-ing in machine learning technology.Result/Conclusion Machine learning plays an important role in the diagnosis and treatment of epi-lepsy,and can provide reference for clinical doctors'diagnosis and treatment work.