Objective:To investigate the effect of a family support nursing intervention on mood, negative psychology, quality of life, and illness perception among elderly patients with breast cancer after radical operation.Methods:A total of 94 patients with breast cancer who had under gone radical mastectomy during the period from August 2016 to May 2019 at the Seventh People′s Hospital of Zhengzhou were randomly divided into two groups: a regular care group (control group, 45 patients) and a family support group (49 patients). The regular care group was provided with routine follow-up care after discharge. The family support group was given a family support nursing intervention, along with routine follow-up care. Hamilton Anxiety Rating Scale (HAM-A), Hamilton Depression Rating Scale (HAM-D), quality of life, and illness perception scores were compared between the two groups before and after the intervention.Results:There were no statistically significant differences in HAM-A, HAM-D, quality of life (physical status, emotional status, functional status, breast cancer-specific module scores, and total score), and illness perception scores (cognitive, emotional, comprehension, and total scores) between the two groups before the intervention ( P>0.05). The HAM-A and the HAM-D scores in the family support group were lower than those in the regular care group after the intervention ［(15.2±1.7) vs. (19.3±2.0) points, (18.0±1.7) vs. (23.1±2.5) points］ ( t=8.061, 8.021; both P<0.001). Physical status, emotional status, functional status, breast cancer-specific module, and total scores in the family support group were higher than those in the regular care group ［(21.3±2.5) vs. (16.4±2.1) points, (18.4±2.0) vs. (15.1±1.7) points, (22.0±2.6) vs. (15.1±1.5) points, (28.8±3.6) vs. (24.8±2.6) points, (113.3±15.5) vs. (101.4±12.5) points］ ( t=10.126, 8.695, 15.508, 6.205, 4.091; all P<0.001). The cognitive, emotional, comprehension, and total scores in the family support group were lower than those in the regular care group ［(29.4±3.0) vs. (34.9±3.7) points, (10.3±1.7) vs. (13.0±1.4) points, (4.1±0.5) vs. (7.4±0.8) points, (48.9±5.3) vs. (59.0±6.1) points］ ( t= 8.063, 8.285, 24.456, 8.597; all P<0.001). Conclusion:Interventions that support the family can improve mood and quality of lifeand enhance illness perception among elderly patients with breast cancer after radical mastectomy.

Objective To observe the effect of supplemental Revolvin D1 (RvD1) on Toll-like receptor 4 (TLR4) in skeletal muscle of type 2 diabetic mice.Methods 35 male C57BL/6 mice were randomly divided into control group (NC group) and high glucose and high fat diet group.After 8 weeks,mice in high glucose and high fat diet group were given intraperitoneal injection of streptozotocin (STZ) 100 mg/ kg.Then they were randomly divided into two groups:Type 2 diabetes group (T2DM group) and type 2 diabetes + RvD1 intervention group (T2DM + RvD1 group).Mice in T2DM group mice were injected with phosphate buffer saline 0.2 ml and T2DM + RvD1 group mice were injected with Revolvin D1 100 ng/day respectively.The levels of fasting blood glucose,serum insulin and inflammatory factors were detected.The mRNA expression level of TLR4 was detected by real-time quantitative polymerase chain reaction (RT-qPCR) method,and the expression of TLR4 protein was detected by Western blot.Results The levels of insulin resistance index,interleukin(IL)-6 and tumor necrosis factor-α (TNF-α) in T2DM group and T2DM + RvD1 group increased (P ＜ 0.05).Compared with the T2DM group,the levels of insulin resistance index,IL-6 and TNF-α in T2DM + RvD1 group decreased (P ＜0.05).The expression of TLR4 protein in T2DM group and T2DM + RvD1 group was higher than that in NC group (P ＜ 0.05).The expression of TLR4 protein in T2DM + RvD1 group,was lower than that in T2DM group (P ＜0.05).The mRNA level of TLR4 in mice was consistent with the above results by RT-qPCR.Conclusions Moderate supplementation of RvD1 can not only decrease the level of inflammatory factors in type 2 diabetic mice,but also reduce the expression of TLR4 and insulin resistance in skeletal muscle of type 2 diabetic mice.

OBJECTIVE: To observe the improvement effects of angiotensin converting enzyme inhibitor (ACEI) fosinopril, perindopril and benazepril on ventricular remodeling in patients with acute myocardial infarction (AMI), and to evaluate its safety. METHODS: A total of 96 AMI patients selected from our hospital during Jan. 2014-Oct. 2016 were divided into group A, B, C according to random number table, with 32 cases in each group. All patients received symptomatic treatment, underwent percutaneous coronary intervention, and then given ACEI after blood vessels recanalization and keeping blood pressure stable. Group A was given Fosinopril sodium tablets 10 mg, qd; group B was given Perindopril tert-butylamine tablets 4 mg, qd; group C was given Benazepril hydrochloride tablets 10 mg, qd. All groups were treated for consecutive 6 months. Cardiac structure and function indexes (LVESD, LVEDD, IVSD, LVPWD, LVEF, CO), hemodynamic indexes (SBP, DBP, HR) and related lab indexes (FPG, TG, TC, HDL-C, LDL-C, AST, ALT, Scr, BUN) of 3 groups were observed before and after treatment. The occurrence of ADR was recorded. RESULTS: Before treatment, there was no statistical significance in cardiac structure and function indexes, hemodynamic indexes or related lab indexes among 3 groups (P＞0. 05). After treatment, the levels of LVESD, LVEDD, LVPWD, CO, HR, FPG, TG, TC and LDL-C in 3 groups were decreased significantly, while the levels of LVEF and SBP were increased significantly, with statistical significance (尸＜0. 05). There was no statistical significance in above indexes among 3 groups after treatment (P＞0. 05). After treatment, the level of Scr in group B was significantly increased and higher than group A and C, with statistical significance (P＜0. 05). There was no statistical significance in the levels of IVSD, DBP, HDL-C, AST, ALT or BUN among 3 groups before and after treatment as well as the level of Scr between group A and C (P＞ 0. 05). There was no statistical significance in the incidence of ADR among 3 groups(P＞0. 05). CONCLUSIONS: Fosinopril, perindopril and benazepril can significantly improve ventricular remodeling in AMI patients, narrowing the heart cavity, increasing systolic pressure, lowering heart rate, reducing the oxygen consumption of the ventricle, with similar effects. Perindopril may increase the level of Scr, so fosinopril and benazepril are safe and suitable for AMI patients with renal function disorder.