1.Effects of Yiqi Huoxue Huayu Chinese medicine on expression of bFGF and neogenesis of blood vessels in BPH rats
Xin YANG ; Yonghua ZHANG ; Caifei DING ; Zhizhong YAN ; Weidong NI
China Journal of Traditional Chinese Medicine and Pharmacy 2005;0(06):-
Objective:To study the effects of Yiqi Huoxue Huayu Chinese medicine on neogenesis of blood vessels and basic fibroblast growth factor(bFGF)expression in benign prostatic hyperplasia(BPH)rats.Methods:7 days after being castrated,fifty SD rats were injected with testosterone(5 mg?kg-1?d-1),the decoction of Yiqi Huoxue Huayu and Zerguilongshuang were orally administrated respectively,after 30 days'treatment,the rats were sacrificed,the prostate volume were measured,and the prostate index(PI)were analyzed,the micro-vessels density(MVD)and level of bFGF were measured.Results:The prostate volume and index of rats in model group was obviously higher than those in normal group(P
2.Protective Effect of Extract from Morindae Officinalis on the Oxidative Injury of Human Sperm Motility
Zhi-zhong YAN ; Xin YANG ; Yong-hua ZHANG ; Caifei DING ; Jing DU
Chinese Journal of Rehabilitation Theory and Practice 2006;12(8):701-703
ObjectiveTo observe the protective effect of extract from Morindae officinalis on the oxidative injury of human sperm motility.MethodsThe sperm specimens were cultivated in vitro, the reactive oxygen species (ROS) was made from hypoxanthine-xanzine xanzine (HX-XO), and sperm specimens were co-incubated with ROS and different dosages of extract and oxygen. The motor parameters were evaluated, the motility were analyzed by the test of capillary tube penetrating, and compared with the control group.ResultsThe sperm function were injured, the motility and penetrating ability decreased evidently under the action of ROS, and with a significant difference compared with the normal group ( P<0.001). The sperm motility and penetrating ability could be improved by all of the small, medium and massive extract compared with vitamin C, especially 0.25 and 0.5 g/ml Morindae officinalis had more evident action in the rate of progressive motility and vitality exponent.ConclusionThe ROS can injury the sperm motility and penetrating ability, the appropriate content of extract from Morindae officinalis can significantly intervene peroxidation in sperm by the ROS, and protect the sperm motility.
3.Progress of research on Maple syrup disease.
Caifei YANG ; Tao CHEN ; Xiaoguang LEI ; Yuexian LIU ; Mengyuan XU ; Dan YANG
Chinese Journal of Medical Genetics 2019;36(7):737-741
Maple syrup disease (MSUD) is a rare autosomal recessive disorder caused primarily by mutations of branched-chain keto acid dehydrogenase complex (BCKDC). BCKDC includes at least four pathogenic genes of BCKDHA, BCKDHB, DLD and DBT. The clinical manifestations of MSUD are complex, and the main symptoms at the early stage include difficulty in feeding, drowsiness, change in muscle tone and special urine flavor of maple syrup. As the disease progresses, convulsion, hypoglycemia, coma and systemic failure may occur. MSUD is easily missed or misdiagnosed during the neonatal period. This paper provides a review for recent progress made in research on MSUD including etiology, physiopathology, clinical manifestation, auxiliary examination and treatment, with a particular emphasis on genetic testing and treatment.
3-Methyl-2-Oxobutanoate Dehydrogenase (Lipoamide)
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genetics
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Humans
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Maple Syrup Urine Disease
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diagnosis
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genetics
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therapy
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Mutation
4. Research progress on the effect of rhythmic sensory cueing on motor function of Parkinson′s disease
Mengyuan XU ; Tao CHEN ; Yuexian LIU ; Caifei YANG ; Qingyun PENG ; Dan YANG ; Xiaoguang LEI
Chinese Journal of Neurology 2020;53(1):72-78
Oral medicine and deep brain stimulation are two main treatments for Parkinson′s disease (PD). But their long-term efficacies are decreasing, which limit the choice of patients in advanced stage. As a special way of sensory intervention, rhythmic cueing can improve gait parameters, reduce freezing of gait severity and improve gait-related mobility by activating the motor pathway directly, repairing internal clock, promoting internal dopamine release and improving cognitive function to maintain gait stability. Rhythmic auditory and visual cueing has a potential in PD treatment.
5.Progress on quantitative assessments of motor symptoms for Parkinson′s disease
Mengyuan XU ; Tao CHEN ; Xu MENG ; Yuexian LIU ; Caifei YANG ; Xiaoguang LEI
Chinese Journal of Neurology 2020;53(10):845-854
Clinical scales and external devices are two important ways to quantify the severity of motor symptoms for Parkinson′s disease (PD). As one representative of scales, the Unified Parkinson′s Disease Rating Scale is considered the "gold standard" in the comprehensive assessment of PD. External devices are divided into electrophysiological and mechanical devices based on the type of sensors. Both sides can monitor the PD motor symptoms objectively. Currently, numerous and ununified parameters of devices make the clinical quantification of PD symptoms still rely on scales. This article reviewed the progress on quantitative assessments of motor symptoms for Parkinson′s disease.