In order to illuminate the effective compounds in Tibetan medicine kandrakari, chemical composition of dry stems of Rubus amabilis were studied by means of various chromatographic techniques, leading to the isolation of 11 compounds. On the basis of spectroscopic data, their structures were elucidated as 1,8-dihydroxy-3,7-dimethoxyxanthone (1), 1-hydroxy-3,7,8-trimethoxyxanthone (2), 1,8-dihydroxy-3,5-dim ethoxyxanthone (3), kaempfero-3-O-(6"-trans-p-coumaroyl) -beta-D-glucopyranoside (4), quercetin (5), kaempferol (6), hyperoside (7), luteolin-7-O-beta-D-glucopy ranoside (8), apigenin-7-O-beta-D-glucopyranoside (9), isovitexin-7-O-glucoside (10), and procyanidin B4 (11). Compounds 1-3 were isolated from the Rubus genus for the first time,and compounds 1-6, 10-11 were isolated from R. amabilis for the first time.
Drugs, Chinese Herbal ; chemistry ; Medicine, Tibetan Traditional ; Molecular Structure ; Rosaceae ; chemistry ; Spectrometry, Mass, Electrospray Ionization ; Tibet

Objective:To explore the effect of head scraping combined with ear acupoint embedding beans in patients with stroke and insomnia due to heart-spleen deficiency.Methods:From September 2020 to September 2021, convenience sampling was used to select 60 stroke and insomnia patients treated in the Neurology Department, the First Affiliated Hospital of Hunan University of Chinese Medicine as the research object. The patients were randomly divided into the observation group and the control group, 30 cases in each. The control group was given oral alprazolam tablets, and the observation group was given the head scraping combined with ear acupoint embedding beans on the basis of the control group. Both groups were given intervention for 14 days. The clinical efficacy, Pittsburgh Sleep Quality Index (PSQI) score, and Self-Rating Anxiety Scale (SAS) score were compared between the two groups before and after the intervention.Results:After the intervention, the SAS and PSQI scores of the two groups were lower than those before the intervention, and the SAS and PSQI scores of the observation group were lower than those of the control group, with statistical differences ( P<0.05) . After the intervention, the total clinical effective rate of the observation group was 98.7%, which was higher than that of the control group (66.7%) , with a statistically significant difference ( P<0.05) . Conclusions:Head scraping combined with ear acupoint embedding beans can effectively improve the sleep quality and anxiety of stroke and insomnia patients with heart-spleen deficiency.