No abstract available.
Cafe-au-Lait Spots ; Nevus*

No abstract available.
Cafe-au-Lait Spots* ; Chromosomes, Human, Pair 15* ; Humans

Disfiguring hyperpigmentation of the exposed areas may have impartant and lasting effects on the emotional well-being of the patient. And many attempts to treat areas of hyperpigmentation have been earried out, but all of them are not very successful. Recently 4-isopropylcatechol has been known to inhibit melanin pigmentation with a selective action on melanocytes either destroying or inactivating the melanocytes experimentally. There is no report on its clinical trial till now. In this study, 1% 4-isopropylcatechol cream was topieally applied to the hyperpigmented lesions of 29 patieots of melasma, freckle, and cafe-au-lait spot. The bleaching effect on meiasmas was very satisfactory in all patients but coantact dermatltis in 3 patients and reticular hyperpigmentation with areas of depigmented spots in one patient were developed as the side effects of the drug. Freckle and cafe-au-Iait spots were not bleached.
Cafe-au-Lait Spots ; Humans ; Hyperpigmentation ; Melanins ; Melanocytes ; Melanosis ; Pigmentation

We observed 17 cases of cafe au lait spots histopathplogi ally. Out of 17 cases, 9 cases were neurofibromatosis with neurofibromas, 6 cases were neurofibromatosis without neurofibroma, and 2 cases were normal healthy persons. The results were as follows. l. In all 17 cases, melanin pigment was increased in melanocytes and keratinocytes. 2. Griant pigment granules were identified only in 3 cases of neurofibromatosis with neurofibromas.
Cafe-au-Lait Spots* ; Humans ; Keratinocytes ; Melanins ; Melanocytes ; Neurofibroma ; Neurofibromatoses

Congenital pseudarthrosis of the tibia is a condition most often combined with cafe-au-lait spots and neurofibromatosis. It is notoriously difficult to attain a sound bony union. Compression plating and screw fixation with massive bone graft resulted in successful union in our case.
Cafe-au-Lait Spots ; Neurofibromatoses ; Pseudarthrosis ; Tibia ; Transplants

Malignant peripheral nerve sheath tumor is a neoplasm that most often arises in anatomically discernible peripheral nerves or neurofibroma. A 37-year-old woman presented with a rapid growing pedunculated, huge mass on the left breast for 1 month. She has suffered from neurofibromatosis type 1 with multiple cafe au lait spots and neurofibromas. The huge mass has developed from a subcutaneous nodule on the left breast. The clinical and histopathological data showed a malignant peripheral nerve sheath tumor. Since no sign of the metastasis was observed, local excision was performed. We, herein, report a case of malignant peripheral nerve sheath tumor developed in the patient of nurofibromatosis type 1.
Adult ; Breast ; Cafe-au-Lait Spots ; Female ; Humans ; Neoplasm Metastasis ; Neurofibroma ; Neurofibromatoses* ; Neurofibromatosis 1 ; Peripheral Nerves*

We report a case of suspicious neurofibromatosis associated with multiple spinal tumors with dual pathology. The patient was a 16-year-old girl who had developed progressive paraparesis for 6 months. She had cafe-au-lait spots and multiple subcutaneous nodule. Magnetic resonance(MR) imaging of the lumbar spine had shown dumbbell-shape spinal tumor at L1-2. The tumor had been removed successfully at the local hospital. But, she had got worse to paraplegia. Postoperative MR image of the whole spine had revealed multiple spinal tumors at T3-4, T6-7, C2-3, C7-T1. She underwent 3 additional operations to remove the compressive lesions. Histopathologic findings documented 3 schwannomas and 2 meningiomas. She improved dramatically and was discharged from the hospital. Subsequent MR images of the whole spine revealed numerous small spinal tumors around the spinal cord and cauda quina.
Adolescent ; Cafe-au-Lait Spots ; Female ; Humans ; Meningioma* ; Neurilemmoma* ; Neurofibromatoses ; Paraparesis ; Paraplegia ; Pathology ; Spinal Cord ; Spine

Neurofibromatosis(Von Recklinghausen's disease) is an autosomal dominant disease that affects one in 2,500-3,000 births. The clinical presentation is characterized by multiple pigmented lesions of the skin, known as cafe-au-lait spots, and neurofibromas of the skin. The criteria for diagnosis are at least six cafe-au-lait spots, each greater than 1.5cm in diameter and positive family history and biopsy of a neurofibroma. Management of benign neurofibromatosis must be individualized for each patient and ranges from incisional biopsy to wide local excision. Genetic counseling is advised for all patients with this disease, since no cure is available. We report the case of multiple neurofibromatosis with oral, parapharyngeal space and whole body lesions that was treated with surgical excision.
Biopsy ; Cafe-au-Lait Spots ; Diagnosis ; Genetic Counseling ; Humans ; Neurofibroma ; Neurofibromatoses* ; Parturition ; Skin

Plexiform neurilemmoma is a relatively rare, benign peripheral nerve sheath tumor, whieh usually arises in either the dermis or subcutaneous tissue. These tumors may occur singly or as multiple lesions (plexiform neurilemmomatosis), We report an unusual case of plexiform neurilemmomatosis associated with cafe au lait spots reminiscent of neurofibromatosis clinically and another case of plexiform neurilemmoma on the finger. A Biopsy revealed the characteristic palisaded arrangement of spindle cells within well circumscribed elongated nodules, The skin lesions were completely excised without recurrence thereafter.
Biopsy ; Cafe-au-Lait Spots ; Dermis ; Fingers ; Neurilemmoma* ; Neurofibromatoses ; Peripheral Nerves ; Recurrence ; Skin ; Subcutaneous Tissue

Segmental neurofibromatosis(neurofibromatosis type V) is rare disorder characterized by limitation of cafe-au-lait spots and neurofibroma or only neurofibroma on a given unilateral segment of the body. We report a case of segmental neurofibromatosis that developed in a 58-year-old male. The skin lesion was situated on the right antecubital area and wrist in the distribution of dermatomes C5 and C6. Histopathologic examination showed well-demarcated, non-encapsulated tumor of the dermis was composed of thin wavy collagenous fibers and loosely spaced spindle cells with elongated wavy nuclei. The patient was treated with surgical excision and carbon dioxide laser.
Cafe-au-Lait Spots ; Collagen ; Dermis ; Humans ; Lasers, Gas ; Male ; Middle Aged ; Neurofibroma ; Neurofibromatoses* ; Skin ; Wrist