No abstract available.
Cadmium Poisoning* ; Cadmium* ; Zinc*

No abstract available.
Animals ; Cadmium Poisoning* ; Cadmium* ; Olfactory Bulb* ; Rats*

No abstract available.
Animals ; Cadmium Poisoning* ; Cadmium* ; Olfactory Mucosa* ; Rats*

This study was performed in order to investigate the effects of taurine on cadmium poisoning in muscle, gill, and bone tissues of wild goldfish. For this experiment, 80 wild goldfish were divided into four experimental groups: 0.3 mg/L of cadmium and 0 mg/L of taurine (Group I), 0.3 mg/L of cadmium and 20 mg/kg of taurine (Group II), 0.3 mg/L of cadmium and 40 mg/L of taurine (Group III), and 0.3 mg/L of cadmium and 80 mg/L of taurine (Group IV). The results were as follows: The cadmium concentration in muscle tissue of wild goldfish was 0.65-3.21 mg/kg wet wt in Group I, whereas it decreased in Group IV. Levels of cadmium in gill tissue of wild goldfish were 16.57-42.39 mg/kg wet wt in Group I, 15.23-43.01 mg/kg wet wt in Group II, 15.11-39.56 mg/kg wet wt in Group III, and 13.15-38.55 mg/kg wet wt in Group IV (P < 0.05), suggesting that the cadmium concentration decreased in the experimental groups compared to control. The cadmium concentration in bone tissue of wild goldfish after 28 days was 0.52-9.75 mg/kg in Group II, whereas it increased in Group III (P < 0.05). In conclusion, taurine may have a preventive effect against cadmium accumulation in biological tissues.
Animals ; Bone and Bones ; Cadmium ; Cadmium Poisoning ; Gills ; Goldfish ; Muscles ; Taurine

Tolerance to several toxic effects of cadmium, including lethality has been shown following pretreatment with cadmium and zinc. This study was designed to determine if tolerance also develops to Cd-induced hepatotoxicity and renal toxicity. Three groups of rats (A, B, C), each consisting of 16 rats, were studied and each group was divided into four subgroups (1, 2, 3, 4), 4 rats for each subgroup. Rats were subcutaneously pretreated with saline (A), CdCl2(0.5 mg/kg, B), and ZnCl2 (13.0 mg/kg, C) during time periods of 1~6 weeks. At the end of the period, rats were challenged with CdCl2 (3.0, 6.0 and 9.0 mg/kg, ip). After giving the challenge dose, cadmium and metallothionein (MT) concentrations were determined and also observed the histologic change in liver and kidney. The concentration of cadmium in liver and also observed the increased dose-dependently to the challenge dosage. These data indicate the kidney is a major target organ of chronic cadmium poisoning, and suggest that cadmium induced hepatic injury, via release of Cd-MT, may play and important role in the nephrotoxicity observed in response to long-term exposure to cadmium. In addition, histologic examination of group A2, A3 and A4 revealed moderate to severe cadmium toxicity, evidenced by infiltration of inflammatory cells, cell swelling, pyknosis, enlarged sinusoids and necrosis in liver, and tubule cell necrosis and degeneration in kidney. However, MT concentrations in liver and kidney were increased by the pretreatment of CdCl2 and ZnCl2 and their morphological findings were not significantly changed, comparing with control group. Higher MT concentration in liver and kidney observed in the pretreated groups constitutes a plausible explanation of the protective effects of pretreatment against the cadmium toxicity after challenge dosing.
Animals ; Cadmium Chloride* ; Cadmium Poisoning ; Cadmium* ; Kidney* ; Liver* ; Metallothionein* ; Necrosis ; Rats* ; Zinc

Along with global environmental pollution resulting from economic development, heavy metal poisoning in children has become an increasingly serious health problem in the world. It can lead to renal injury, which tends to be misdiagnosed due to the lack of obvious or specific early clinical manifestations in children. Early prevention, diagnosis and intervention are valuable for the recovery of renal function and children's good health and growth. This paper reviews the mechanism of renal injury caused by heavy metal poisoning in children, as well as the clinical manifestations, diagnosis, and prevention and treatment of renal injury caused by lead, mercury, cadmium, and chromium.
Cadmium Poisoning ; Child ; Chromium ; poisoning ; Heavy Metal Poisoning ; Humans ; Kidney Diseases ; chemically induced ; Lead Poisoning ; Mercury Poisoning ; Poisoning ; complications

Metallothionein(MT) is a low molecular weight protein that is induced as a defence mechanism for cadmium (Cd) toxicity. In present study, urinary MT was determined using a competitive ELISA in Cd-exposed rats. In addition, measures the urinary, blood and renal Cd concentration and the urinary excretion of total protein, beta 2-microglobulin (MG) and N-acetyl-beta-D-glucosaminidase(NAG) at 1, 3, 7, 14, 28 days after Cd injection in Cd-exposed rats with dosers of 0.8 and 1.6 mg Cd/kg body weight respectively. The urinary, blood and renal Cd were specific for Cd-exposure, that increased in proportional to dose of Cd. The urinary and blood Cd tended to slightly decrease, while renal Cd tended to increase by lapse of time after Cd exposure. this finding indicates that renal Cd is more specific than urinary and blood Cd for Cd exposure. The urinary excretion of MT showed a statistically significant increase in Cd exposed rats(0.8 and 1.6 no Cd/kg body weight). The increase of urinary excretion of MT was more evident at 7, 14, 28 lays after Cd exposure than the changes of urinary excretion of total protein, beta-MG and NAG. The Pearson's correlation coefficients between urinary Cd and urinary MT, beta-MG, NAG and total protein were 0.4344, 0.3727, 0.3307 and 0.2099, respectively. These findings indicate that the urinary MT is more sensitive and specific than total protein, beta-MG and NAG for Cd exposure. The present results suggest that the urinary MT, using a simple and rapid competitive ELISA, is a valuable index as screening test in epidemiologic study for Cd exposed group.
Acetylglucosaminidase ; Animals ; beta 2-Microglobulin ; Body Weight ; Cadmium Poisoning* ; Cadmium* ; Enzyme-Linked Immunosorbent Assay ; Mass Screening ; Metallothionein* ; Molecular Weight ; Rats

One of the most obvious effects of cadmium poisoning in experimental animals is induction of testicular necrosis. Many studies have been conducted, but the mechanism of the disturbance, which is peculiar to the testicle, has not been elucidated. Testicular damage due to cadmium exposure greatly differs depending upon strains of mice and methods of administration. As a preventive measure against testicular necrosis due to cadmium, pretreatment of small doses of cadmium and several kinds of metals have been found to be effective. In order to examine testicular damage by cadmium doses and protective effects by small doses of metals (Cd, Cu, Se, Mn) and phenobarbital which were administered before single challenge dose of cadmium, mature male I. C. R. mice, 16 weeks of age, weighing approximately 40g were used in this study. The weights of the body and the testicle, cadmium concentration in the testicle and results of histopathological findings of the experimental groups were as follows. 1. With regard to the body weight of each group that was injected intraperitoneally with single cadmium doses of 0.5, 1.O, 2.O and 3.Omg/kg the last two groups showed a significant decrease in one week. 2. Relative testicular weight (testicular weight ,body weight) one week after cadmium administration decreased significantly in the group of more than 1.Omg/kg administration. However, in the pretreatment groups, it was found that the group pretreated with cadmium did not decrease. 3. Cadmium concentration in the testicle in each group increased with the amount of cadmium doses. However, in the pretreatment group, the groups pretreated with cadmium and manganese did not increase. 4. In histopathological findings of the testicle on the 7the day after cadmium administration, the minimum dose of cadmium that induced edema in the interstitial tissue and inactive spermatogenesis in a few germinal epithelia was O.5 mg/kg, but the changes seemed to be due to inhibitory effect for spermatogenesis rather than direct injury to the testicular tissue. Necrosis was observed in the spermatogenic epithelium in the 2.O mg/kg group and severe necroses were extended to the interstitial tissue in the 3.O mg/kg group. The critical concentrations of cadmium for the histopathological change in the testicular tissue was 0.32ug/g and that for necrotic change was 0.60ug/g. 5. Protective effect in the pretreatment groups was noticeable in the cadmium pretreated group and moderate effect in the manganese group; however, in the other metal groups and the phenobarbital group little effect was observed. 6. Comparison of the histopathological findings between the group of pretreatment showing effect.
Animals ; Body Weight ; Cadmium Poisoning ; Cadmium* ; Edema ; Epithelium ; Humans ; Male ; Manganese ; Metals* ; Mice* ; Necrosis ; Phenobarbital ; Spermatogenesis ; Testis* ; Weights and Measures

OBJECTIVETo explore the health status of workers exposed to Cd at low concentration.

METHODSOne hundred eighteen workers of zinc powder finishing and 34 staffs were served as the exposure group and control group, respectively. The physical examination, blood cadmium, urinary cadmium, blood lead, urinary 32-microglobin, urine creatine, chest film, pulmonary function , pure tone teat and were detected for all subjects.

RESULTSTwelve air samples from 6 monitoring points in workshop were detected, the air Cd concentrations were 0.002-0.015 mg/m³, which were under the national limit of occupational exposure. In exposure group, the rates of exceeding standards of blood Cd and urinary Cd were 65.25% and 38.16%, respectively, the rate of exceeding standards of urinary Cd for two times was 27.12%, the rate of exceeding standard of urine Cd for two times plus the positive urinary 32-microglobin was 2.54 %. In control group, the rates of exceeding national standard of blood Cd was 26.47 %, but the values of urinary Cd were normal. In exposure group, the rate of exceeding standards of urinary Cd increased with the service length. Smoking could enhance the rates of exceeding standards of blood Cd and urinary Cd.

CONCLUSIONIn zinc powder finishing, the low-concentration cadmium exposure could cause the occupational cadmium poisoning, the comprehensive protection measures can reduce the occupational cadmium poisoning. It is suggested that the limits of occupational exposure to cadmium should be declined.

Adult ; Cadmium ; blood ; urine ; Cadmium Poisoning ; Female ; Humans ; Male ; Middle Aged ; Occupational Exposure ; Smoking ; epidemiology ; Workplace ; Young Adult ; Zinc ; analysis

When garlic (Allium sativum) was administered to rat per os simultaneously with cadmium, methylmercury and phenylmercury to detect the protective effect against the heavy metal poisoning, accumulation of heavy metals in liver, kidneys, bone and testes were decreased, and histopathological damages and the inhibition of serum alkaline phosphatase activities by heavy metals were reduced. Such effect of garlic was not shown in the 1.7% garlic treated group and most remarkable in the 6.7% garlic treated group. The protective effect of garlic was superior to those of 2,3 dimercapto-1-propanol (BAL) and D-penicillamine (PEN), and nearly similar to those of 2,3-dimercaptosuccinic acid (DMSA) and N-acetyl-DL-penicillamine (APEN), the current remedies, while garlic was not effective as a curative agent for heavy metal poisoning. The excretion of cadmium was enhanced, more through feces than urine by garlic but the effect to the urinary excretion of cadmium was not significant comparing with DMSA or APEN when cadmium was ip injected in the first 3 days during the 12 days of oral administration of DMSA, APEN or garlic.
Animals ; Cadmium/metabolism ; Cadmium Poisoning/metabolism/*prevention & control ; *Garlic ; Male ; Mercury/metabolism ; Mercury Poisoning/metabolism/*prevention & control ; *Plants, Medicinal ; Rats ; Rats, Inbred Strains ; Tissue Distribution