1.A case of immune-mediated type 1 diabetes mellitus due to congenital rubella ınfection
Hüseyin Anıl KORKMAZ ; Cağatay ERMIŞ
Annals of Pediatric Endocrinology & Metabolism 2019;24(1):68-70
		                        		
		                        			
		                        			Congenital rubella infection is a transplacental infection that can cause intrauterine growth retardation, cataracts, patent ductus arteriosus, hearing loss, microcephaly, thrombocytopenia, and severe fetal injury. It has been shown that type 1 diabetes mellitus develops in 12%–20% of patients with congenital rubella infection, and disorders in the oral glucose tolerance test is observed in 40% of patients. No biochemical or serological markers exist which could indicate that type 1 diabetes was caused by a congenital rubella infection. We report a 13-year-old male patient who was admitted to our hospital with complaints of new-onset polyuria, polydipsia, urination, and weight loss. In addition, he was found to have neurosensory hearing loss, patent ductus arteriosus, and microcephaly. Immunemediated type 1 diabetes mellitus was considered due to the fact that the autoantibodies of diabetes mellitus were positive.
		                        		
		                        		
		                        		
		                        			Adolescent
		                        			;
		                        		
		                        			Autoantibodies
		                        			;
		                        		
		                        			Cataract
		                        			;
		                        		
		                        			Diabetes Mellitus
		                        			;
		                        		
		                        			Diabetes Mellitus, Type 1
		                        			;
		                        		
		                        			Ductus Arteriosus, Patent
		                        			;
		                        		
		                        			Fetal Growth Retardation
		                        			;
		                        		
		                        			Glucose Tolerance Test
		                        			;
		                        		
		                        			Hearing Loss
		                        			;
		                        		
		                        			Humans
		                        			;
		                        		
		                        			Male
		                        			;
		                        		
		                        			Microcephaly
		                        			;
		                        		
		                        			Polydipsia
		                        			;
		                        		
		                        			Polyuria
		                        			;
		                        		
		                        			Rubella
		                        			;
		                        		
		                        			Thrombocytopenia
		                        			;
		                        		
		                        			Urination
		                        			;
		                        		
		                        			Weight Loss
		                        			
		                        		
		                        	
 
            
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