The 10th Annual Meeting of the Chinese Society of Clinical Oncology (CSCO) was held on 19-23 September 2007 in Harbin. The theme of this conference was "putting standard multidisciplinary cancer management into practice" and special reports of standard multidisciplinary management on various cancers were presented. Over 3 500 clinical oncologists and scientists participated in the 2007 CSCO Annual Meeting where more than ten international top experts were invited to exchange valuable experiences with the delegates. The programs consisted of Education Session, Satellite Symposium and Meet the Professor Session. The latest research results were presented as oral presentations and posters at the congress. Several hotspots were particularly highlighted in this report, including innovative radiotherapy and chemotherapy methods, researches on molecular targets and clinical trials of targeted therapy, such as endostatin, volociximab, cetuximab, bevacizumab and temozolomide. The remarkable research results of anti-cancer Chinese medicine, cancer screening and prognosis were also introduced. This article tries to call the attention to some hot topics in the program that are both new and noteworthy, and it may serve as a highlight of this important international cancer research meeting for clinical oncologists and scientists.

Intracranial tumor is the most common primary neoplasm in the central nervous system, it is a complex, heterogeneous and hard to cure disease. Current treatments include gross resection of the tumor, radiotherapy, chemotherapy, immunotherapy and Chinese medicine treatment. Despite valiant efforts, prognosis remains dismal. The thrust of an integrated approach to increase disease-free survival and improve quality-of-life is urgently required. In the era of molecular targeted therapy, recent promising diagnostic and therapeutic strategies have resulted from advancement in understanding molecular brain tumor biology, neuroimaging, neurosurgical treatment, radiotherapy, combined chemotherapy and molecular therapy. This review outlines the current status of diagnosis and therapeutic intervention in intracranial tumor. The article discusses the perspective of molecular therapy. This approach includes new technologies, such as genomics, proteomics, nanomedicine and metabolomics.
Brain Neoplasms ; diagnosis ; genetics ; pathology ; therapy ; Humans ; Integrative Medicine ; methods ; Medicine, Chinese Traditional

Proteinchip profiling is a powerful and innovative proteomic technology for biomarker discovery and diagnostic/prognostic assay development. Based on surface-enhanced laser desorption/ionization time-of-flight mass spectrometry (SELDI-TOF MS), Ciphergen's proteinchip system offers a single, unified, high-throughput platform for a multitude of proteomic research applications. Proteins are the major functional components of the cell, the study of proteomics provides mankind with a better understanding of disease and life. The remarkable findings in disease biomarkers have shed light to the early diagnosis, monitoring and predicting prognosis of various diseases, especially for cancer. In this article, the development and technology of SELDI-TOF MS are introduced. Some research progress and encouraging research results in oncoproteomics, infectious diseases, neurological diseases and diabetes mellitus using SELDI-TOF MS are also reviewed. The paper is closed by the appraisals on its pros and cons, as well as the future prospective is also expounded.
Animals ; Computational Biology ; Humans ; Lasers ; Mass Spectrometry ; methods ; Protein Array Analysis ; methods ; Proteomics ; Surface Properties

DNA expression profiling using microarray technology has been applied to studies on the molecular classification of lung cancers, pathogenetic alterations in gene expressions and cellular path-ways, prediction of prognosis and metastasis, customized therapies, and drug development. Due to the wide variation in technical factors, different cohorts of patients and biological heterogeneity, the major hur-dle to successful clinical application is lack of robustness, reliability and reproducibility of data. With better standardization and better analytic approaches to cut down the noises from the high dimensionality of data, microarray technologies may be ready to make its way to the doctor's office with contribution to personal-ized treatment of lung cancer in the future.