Multi-drug resistance (MDR) of cancer cells is a major cause of failure of chemotherapy in cancer treatment. Most MDRs are caused by overexpression of P-glycoprotein (P-gp) which effuses chemotherapeutic agents out of cells. Nano drug delivery systems (NDDS) have been valued for their characteristics including drug targeting, slow-releasing, and long circulation time in the body. Through mechanisms such as non-specific endocytosis and receptor-mediated endocytosis, NDDS can inhibit P-gp at the gene and protein level, leading to improved concentrations of chemotherapeutic drugs in cancer cells, and therefore reverse MDR.

To discuss the immune mechanism of the acupuncture and moxibustion on allergic rhinitis(AR),which resulted from the summary of the immune mechanism research on AR in the last more than ten years,so as to improve diagnosis and treatment of the acupuncture and moxibustion on AR.To analyze and summarize the immune mechanism of the acupuncture and moxibustion on AR,which based on the data about that in the last more than ten years.

Objective Objective To study the application of oral ranitidine to MRCP. Methods 20 healthy subjects, including 12 males and 8 femals, were performed with random double-blind MRCP examination by 1.5T MR machine. Two experienced radiologist assessed the results. Results Without any side effect, the proximal end and distal end of the common bile duct, bile-cyst were displayed well (P

Antineoplastic Combined Chemotherapy Protocols ; administration & dosage ; Carcinoma, Hepatocellular ; therapy ; Chemoembolization, Therapeutic ; Combined Modality Therapy ; Cyclopropanes ; administration & dosage ; Drugs, Chinese Herbal ; administration & dosage ; Female ; Fluorouracil ; administration & dosage ; Humans ; Infusions, Intra-Arterial ; Liver Neoplasms ; therapy ; Male ; Medicine, Chinese Traditional ; Middle Aged ; Mitomycin ; administration & dosage ; Phytotherapy

Allergy and Immunology ; Ethnic Groups ; Humans ; Hypersensitivity ; immunology

The authors analyzed the current predicament of medical human resources and seek the deficiencies and problems that exist in the medical moral education system .Based on this , this paper pointed out that it should change the medical ethics education ideas , enhance medical ethics cultural identity; based on the health industry demand , broaden the content of the medical ethics education;to develop a new mode of medical ethics education , perfect the evaluation system of medical ethics and health industry demand , provide new guidance for medical eth-ics education .

AIM　to compare the bioavailability and pharmacokinetics of two acyclovir tablets. METHODS　Concentrations of acyclovir in 10 men serum after po 600 mg of two acyclovir tablets were determined , in random 2-way crossover design. Pharmacokinetic parameters were also estimated. RESULTS　The peak concentrations of test and reference tablets were 1.24±0.49 and 1.17±0.20 μg/ml, the AUC 7.56±1.80 and 7.56±2.10μg*h/ml, respectively. The relative bioavailability was 101.36%±11.62%. The test formulation was found bioequivalent to the reference in AUC and Cmax by two one-side t test. CONCLUSION　Two tablets were bioequivalent.

Objective To investigate the risk factors of contrast-induced nephropathy (CIN) in patients after coronary angiography.Methods Two hundred patients underwent coronary angiography were enrolled in this study.The patients were divided into CIN group and non-CIN group according to the occurrence of CIN after coronary angiography of 48-72 h,and then the related risk factors of CIN were analyzed.Results Thirteen cases of CIN were found in 200 patients,and the occurrence rate was 6.5％(13/200).Logistic regression analysis showed that risk factors of CIN included primary renal insufficiency,diabetes,contrast agent dose and advanced age (P ＜ 0.05).Conclusion Primary renal insufficiency,diabetes,contrast agent dose and advanced age are risk factors of CIN in patients after coronary angiography.

Objective:To determine the related substances in dexibuprofen and its sustained release tablets by HPLC .Methods:The related substances including a-methyl-4-butyl benzene acetic acid , L-ibuprofen and the others were detected by HPLC .An Agilent Eclipse XDB-C18 column (150 mm ×4.6 mm, 5 μm) was used for a-methyl-4-butyl benzene acetic acid and the other related sub-stances.A Kromasil 5-TBB column (250 mm ×4.6 mm, 5 μm) was used for L-ibuprofen.The mobile phases was acetonitrile and phosphate solution (45 ∶55, pH value was adjusted to 2.5 by phosphoric acid), hexane-tert-butyl ether-acetic acid (850 ∶150 ∶1), acetonitrile and sodium acetate buffer (60 ∶40, 6.13g sodium acetate was dissolved in 750ml water, and pH was adjusted to 2.5 by glacial acetic acid ) , respectively .The detection wavelength was 214 nm, 220 nm and 263 nm, respectively .The flow rate for a-meth-yl-4-butyl benzene acetic acid and the other related substances was 1.0 ml· min-1 .The flow rate for L-ibuprofen was 2.0 ml· min-1 . The column temperature was 30℃and the injection volume was 20 μl.Results:The method could effectively detect the contents of a-methyl-4-butyl-phenylacetic acid and L-ibuprofen, and identify and separate the related substances in dexibuprofen raw material and its sustained release tablets .Conclusion:The method is specific , accurate and easy to operate , which can be used for the quality control of ibuprofen raw material and its sustained release tablets .

Objective To investigate the application effect of quality control management in the prevention of indwelling catheter associated urinary tract infection in intensive care unit (ICU) patients. Methods Cases of patients stayed in the department of ICU undergoing indwelling catheter over 10 d were selected by using time stage sampling method. Totally 136 cases of patients were selected from January 1, 2012 to December 31, 2012, as the control group. A total of 145 cases of patients were selected from January 1, 2013 to December 31, 2013, as the performance group. Cases in performance group were taken standardized training and quantify the performance appraisal on the basis of measures in the control group. The urine routine was tested and bacterial was cultured at indwelling catheter 3 d, 7 d and 10 d, respectively. The indwelling catheter associated urinary tract infections of the two groups were compared. Results After the implementation of the performance appraisal management, the incidences of indwelling catheter associated urinary tract infection at 3 d, 7 d and 10 d were 4.8%(7/145), 19.3% (28/145) and 32.4% (47/145), respectively. Within each quarter, the incidence of indwelling catheter associated urinary tract infection was rising with indwelling catheter time prolonged. And the incidences of the first and second quarter were higher than three and four quarter. The incidences of indwelling catheter associated urinary tract infections at 3 d, 7 d and 10 d in the performance group were lower than the control group, the differences were statistically significant (χ2=4.494, 30.660 and 49.307, P < 0.05). Conclusions Standardized training of nursing staff in ICU and implementation of performance appraisal management could effectively improve the enthusiasm and sense of responsibility of the nurses, and effectively reduce the incidence of indwelling catheter associated urinary tract infection.