Objective:To observe the effect of hepatic function in hyperthyroidism patients with serum levels of hyaluronic acid(HA),laminin,type Ⅲ procollagen peptide and type IV collagen.Methods:We measured them in 140 patients with Graves' disease and 33 healthy subjects by radioimmunoassay.Graves' disease patients were divided into two groups,one including 59 patients with primary diagnosis and not treated with antithyroid drug(ATD),the other group including 81 patients were once treated with ATD.Results:HA concentration was significantly higher( P

The latest results from the FLEX trial wag presented in ASCO annual meeting which was hold in June.2008 in Chicago.The study demonstrated that chemotherapy based on Cetuximab plus Cisplatin significantly increased the overall survival of NSCLC patients,including all histological subtypes.The new findings confirm that Erbitux is the first targeted thempy to show a significant survival benefit in NSCLC patients across all histological subtypes.

s To some extent, liberal education is a kind of cultivation. In essence, cultivation and purification are two of the ways of the transformation of human beings, each with its own doctrine and the subsequent applicability. A comparative research between cultivation and purification is made in the article. Based upon the demarcation between the two categories, the author has expounded his own understanding on the idea of the Confucian cultivation in the context of the liberal education in current Chinese university.

Education is social activities that aim to directly impact the physical and mental development of person.And its core value is talent civilization.Generally,universities and colleges have three basic functions,among which cultivating talents is the most fundamental task.Teachers are the professional personnel who carry out the duties of education,and their mission is teaching and cultivating.But there are many unsuitable factors that have been limiting the realization of the mission of universities and colleges.The steps should be taken from thoughts,concepts,regulations and surroundings to make the teachers play dominant roles in the process of teaching and cultivating.

Objective To investigate the morphological difference of spinal single vertebral tuberculosis and metastasis by means of CT.Methods CT features of 16 cases of single vertebral tuberculosis and 17 cases of single vertebral metastasis which were proven by clinically and/or pathology, were retrospectively analyzed,and then the CT differential criteria of the two categories of diseases was recommended.Results The reliable CT findings for vertebral tuberculosis were as follows: involvement of anteriomedial potion of vatebral body,presence of sequstra in lesion ,marginal sclerosis in the edge of lesion,calcification within paravertebralmass or abscesses ,only edge enhancement of more of paravertebralmass.Metastasis was characterized by involvement of posteriomedial portion of vertebral bone,absence of sequestra within lesion ,no calcification within paravertebralmass.Both of them had normal intervertebral disc.Conclusion The different CT features of the single vertebral tuberculosis and metastasis are helpful in differerntiating diagnosis ,the morphological change of intervertebral discs is not helpful in differerntiating diagnosis .

Objective To study the chest X-ray appearances and dynamic imaging changes in severe acute respiratory syndrome diagnosed clinically. Methods The sequential chest X-ray examinations at 1-4 day intervals were performed in 72 patients with severe acute respiratory syndrome. Results The findings on chest X-ray images were analyzed. The abnormalities on the chest X-ray films most commonly occurred at 4-7 days after onset (53 cases, 73.6%), and the most severe manifestations on the chest films usually presented at 8-14 days (54 cases, 75.0%). The absorption of the abnormal changes on the films occurred at 15-21 days in most cases (37 cases, 51.4%). The main features included bilateral or unilateral single or multiple patchy shadows (58 cases, 80.6%), and the lesions changed rapidly at the peak period. The lesions presented wandering features in some cases. The lesions still remained on CT scans in 11 cases (11/20, 55.0%) within one month after the absorption on X-ray film. Conclusion The chest radiography can be used to display dynamic changes of SARS, but it isn't able to distinctly demonstrate tine pulmonary lesions of SARS.

Epidermal growth factor receptor tyrosine-kinase inhibitors (EGFR-TKIs) have elicited curative effects on patients with advanced non-small celllung cancer and with activating mutations in the EGFR gene. However, acquired resistance to EGFR-TKIs is eventually developed after an initial response is induced;as such, patients with acquired resistance must be treated with more ef-fective strategies to delay or possibly overcome the resistance. This article reviews available data on the treatment of patients who have failed to respond to EGFR-TKI.

Acute kidney injury ( AKI) in newborns is one of neonatal critical disease,the incidence of AKI is 23%and the mortality is 25%~50%in neonatal intensive care unit (NICU).AKI in newborns is ab-normal renal function due to many various unfavorable factors,such as neonatal asphyxia,low blood volume, shock,hypoxia,hemolysis,low temperature,the clinical manifestations are oliguria or anuria,electrolyte disturb-ance,acid-base imbalance, high concentrations of metabolites in plasma and renal excretion ( urea, creatinine etc.) .At present,there are no effective prevention measures.In recent years,with the progress of blood purifica-tion technology,continuous blood purification ( CBP) has been used from AKI in children to AKI in newborns. Because of the neonatal hemodynamic instability and blood characteristics of small capacity, the application of CBP in the neonatal AKI still faces many problems.The paper summarizes high risk factors and diagnostic crite-ria of AKI in newborns,related problems of neonatal CBP treatment.

Objective To explore the effect of aspirin resistance on cardiovascular events in non-insulin-dependent diabetes melli-tus patients .Methods 496 patients with non-insulin-dependent diabetes mellitus received daily aspirin therapy (100mg/d) 4 weeks were recruited from Jun .2006 to Sept .2010 .Platelet aggregation was measured by light transmission aggregometry .The patients were divided into three groups :aspirin resistance group ,aspirin semi-resistance group and aspirin-sensitive group .The clinical bio-chemistry indications and the adverse cardiovascular events were collected .Results 11 .69% of patients were found to be resistant to aspirin therapy ,and 37 .90% of patients to be aspirin semi-responders .There were 67 .48% female in aspirin resistance group and aspirin semi-responders .The preprandial glucose of group AR and ASR was higher than that of group AS (P<0 .05) .The HbA1C and TG of group AR were higher than those of group AS(P<0 .05) .There was statistically significant difference of the rate of car-diovascular events .Conclusion The measure of platelet aggregation should be taken in the diabetic mellitus patients and pay atten-tion on the dose of aspirin recommended .Particular attention is should also devote to the incidence of adverse cardiovascular events .

Headache is a common clinical symptom.Some headache disorders belong to secondary category.Many intracranial disorders,such as head trauma,cerebral vascular diseases,intracranial tumors and inflammation,can lead to headache due to mass effect,inflammation reaction,stimulation of vasoactive substances and decreased intracranial pressure.Furthermore,many drugs and other substances,disorders of eyes,nose,ear,mouth,neck and other systemic disorders can also cause headache.Many headache disorders can be determined by detailed case history and physical examination.Blood test,lumber puncture,CT,MRI and other imaging examinations are necessary methods for finding the causes and the treatment of diseases.