Objective: To understand the level of depressive symptoms and associated factors in alopecia college students in Changchun. Methods: The convenience sampling method was used to select 275 alopecia students from outpatient clinics in the Affiliated Hospital of Changchun University of Traditional Chinese Medicine during November 2019 to June 2021. Center for Epidemiological Survey, Depression Scale(CES-D) and general characteristics were collected. Depressive symptoms and its associated factors were analyzed by binary Logistic regression. Results: A total of 121 students with hair loss reported depressive symptoms, with the detection rate of 44.0%. Female( OR=2.26, 95%CI =1.22-4.20), 26-30 years of age( OR=2.43, 95%CI =1.01-5.85), poor sleep quality( OR=13.63, 95%CI =4.09-45.42), substantially affected interpersonal relationship( OR=3.56, 95%CI =1.57- 8.06 ), perceived severe stress ( OR=3.73, 95%CI =1.35-10.30) were positively correlated with depressive symptoms in alopecia college students, and 1-2 times of exercise per week, 3-5 times of exercise per week, and >5 times of exercise per week ( OR= 0.17 , 0.14, 0.03, 95%CI =0.05-0.61, 0.04-0.52, 0.01-0.14) were negatively correlated with depressive symptoms in alopecia college students( P <0.05). Conclusion Depressive symptoms are reported in 44.0% of alopecia college students in Changchun, which might be related with age, gender, sleep quality, interpersonal distress, stress perception and exercise.