1.Management and Control of Nosocomial Infection
Chinese Journal of Nosocomiology 2009;0(20):-
OBJECTIVE To investigate the effective methods for nosocomial infection management and control so as to adapt the needs of quality-control in modernized hospital.METHODS By changing ideas,boosting precaution skills,optimizing reasonable flow of work,making practicable rules and regulations,ensuring information unblocked,and continuously refining work approaches were used to improve our nosocomial infection management level in all directions in practice.RESULTS The rules and regulations of nosocomial infection had been carried out and nosocomial infection had been controlled effectively.CONCLUSIONS Modernized management methods,process management and continuously quality-improving are very meanningful to elevate the nosocomial infection management level,and to ensure the quality of medical service.
2.Therapeutic Analysis of Hepatic Artery Chemoembolization in 60 Patients with Middle-Late Hepatocarcinoma
Journal of Practical Radiology 2000;0(02):-
Objective To evaluate the therapeutic effect of middle-late hepatocarcinoma by transcather arterial chemoembolization (TACE).Methods 60 patients with middle-late hepatocarcinoma were undergone selective hepatic artery catheter purfusion chemotherapy combined with iodized oil embolism through femoral artery using Seldinger technique totally . All patients 140 times . Results There were significant effect in 36 cases (60%),effect in 19 cases (31.7%) and stable in 5 cases(8.7%) after treatment.The survival rate has been improved,38 cases ( 63.3%) have survived for more than 12 months . Conclusion For the patients with middle-late hepatocarcinoma,TACE is curative effect,it can prolong survival time significantly and improve patient’s life quality.
3.Nephron sparing surgery for renal neoplasms(report of 18 cases)
Bin CHEN ; Jinchun XING ; Shixin CHEN
Journal of Clinical Surgery 2001;0(01):-
Objective To probe the nephron spring surgery for renal neoplasms.Methods Form April 1995 to October 2001,nephron sparing surgery was done for 18 cases of renal tumor,of which there were 3 with carcinoma and 15 with benign neoplasms.Among them,1 case was sole kidney;and 17 cases were a unilateral renal neoplasm and a normal opposite kidney.The diameter of the tumor ranged from 1 cm to 8 cm,with a mean of 3.5 cm.17 patients underwent partial nephrectomy and 1 tumor nucleation.Result All patients have been followed up for 2 to 72 months with a mean of 32 months,no surgical complication or local tumor recurrence has been found.Conclusion Nephron sparing surgery is safe and effective for the treatment of renal neoplasms.
4.Application of fluorescence imaging in the research of tumor
Shixin ZHANG ; Mingxin CHEN ; Fangqiu LI
Journal of Medical Postgraduates 2004;0(02):-
Fluorescence imaging of animal in vivo is to tag cell or DNA with fluorescence reporter gene, and then detect the fluorescence using sensitive optics apparatus. With this system, researcher can observe tumor growth, metastasis and angiogenesis in vivo, and reliable information for tumor diagnosis and treatment will be provided for researcher.
5.Angiogenesis and mosaic vessel in colorectal carcinoma.
Weizhen ZHOU ; Wenming CHEN ; Shixin WANG
Chinese Journal of Practical Internal Medicine 2001;0(06):-
Objective To investigate angiogenesis and mosaic vessel in colorectal carcinoma.Methods Forty-nine patients suffering from colorectal carcinoma were studied.Endothelial cell was labelled with monoclonal anti-human CD_~31 antibody,tumor cell was labelled with monoclonal anti-human CEA antibody.Endothelial cell and tumor cell were labelled by double-stained immunohistochemistry.The quantity of microvessel was estimated by counting microvessel density (MVD) at hot spots,and the quantity of mosaic vessels (MV) and double-stained cells were estimated at the same visual field.The relationship between mosaic vessels,microvessel density and Dukes staging were analyzed.Results The MVD in colorectal carcinoma "hot spots" was counted.The MVD of Dukes staging B was 43.98?21.46,staging C was 59.54?26.95,and staging D was 70.80?19.04.MVD increased gradually accompanied by clinical staging.There was statistical difference between staging B and D (P
6.Combined use of near-infrared and other technologies in tumor research
Mingxin CHEN ; Shixin ZHANG ; Fangqiu LI
Journal of Medical Postgraduates 2003;0(09):-
Near-infrared technology can be used as an auxiliary means for the early diagnosis of cancer and for surgical resection of tiny lesion that can not be discriminated by naked eyes,but it can not satisfy the purpose when used alone.Thus,we have developed an integrated technique by combining near-infrared and other technologies,and extended the scope of its application.This article reviews the advances of several integrated techniques applied to tumor research,including double labeled technology of nuclide and near-infrared,the combination of near-infrared and fluorescence resonance energy transfer,the combined use of near-infrared and endoscopy,and the integration of near-infrared with carbon nanotubes.
7.A comparative study of three-dimensional high-resolution MR imaging CPR and MRVE displayed in trigeminal neuralgia vascular responsibility
Lijun CHEN ; Shixin CHEN ; Zedong SUN ; Ning MA ; Lin XU
Journal of Practical Radiology 2015;(10):1708-1711
Objective To investigate the value of the three-dimensional high-resolution magnetic resonance imaging curve planar reformation(CPR)combined with virtual endoscopy reconstruction in vascular compression of trigeminal neuralgia.Methods 65 pa-tients with trigeminal neuralgia performed three-dimensional MR doubly excited balanced steady-state free precession sequence (3D-FIESTA-C),and CPR combined with virtual endoscopy reconstruction was used to evaluate the relationship of neurovascular anato-my.And 60 cases with microvascular decompression (MVD)surgery were analyzed.Results 65 cases of 3D-FIESTA-C CPR com-bined with MRVE showed responsibility vascular with a positive rate of 92.3% (60/65).60 cases of all patients with the results of surgery showed responsibility blood vessels and oppression parts with 3D-FIESTA-C CPR combined with MRVE,and it was found that the findings of oppression had a good consistency with MVD with the diagnose accordance rate of 95% (57/60).Conclusion Three-dimensional high-resolution magnetic resonance imaging CPR combined with virtual endoscopy reconstruction can be a new method to clearly and accurately show the anatomical relationship between blood vessels and nerves,which helps to improve the posi-tive rate of detection and to give operative guidance.
8.Clinical Application of Coronary Angiography with 16-slice Spiral CT
Wei FU ; Shixin CHEN ; Yanhong LAN ; Xiaohua CHEN ; Jianhua LI
Journal of Practical Radiology 2001;0(08):-
Objective To evaluate the influencing factors on image quality and the value of clinical application of coronary artery angiography with 16-slice spiral CT.Methods 16-slice spiral CT angiography was performed in 31 suspected coronary heart disease(CHD).All patients were examined in ordinary scanning (slice 3 mm) and coronary artery scanning (slice 1 mm)with the technique of retrospective electrocardiography gating,and multiplanar reconstruction(MPR),maximum intensity projection(MIP) and volume reconstruction technology(VRT) were done.The showing rate of coronary arteriae,the detecting rate of CHD and the influencing factors on image quality were evaluated by CT.Results 16-slice spiral CT could clearly show RCA1,RCA2,LAD1,LAD2,,LCX1.The image quality was affected by heart rate,breath movement and much calcification in artery,etc.Conclusion 16-slice spiral CT is of significant value in screening and diagnosing coronary artery disease.
9.Study on influencing factors of common chemical disinfectants used to metal
Jian GU ; Yueying CHEN ; Shixin ZHOU ; Xiaodong ZHANG ; Ping DING
Chinese Journal of Disease Control & Prevention 2001;5(1):8-11
Objective In order to find out influencing factors of corrosiveness of common chemical disinfectants used at present for medical instruments on varied metal material, and to offer scientific bases for working -out corresponding state standards. Methods Liquid instruments disinfectants containing chlorine and glutaraldehyde compound disinfectant were chose to take an example to study their corrosiveness to varied sorts and type s of the metal. Sing le related factors were researched by contrast test study in the process of dete rmining metal corrosion rate (R value, mm*a-1) citing from GB10124-88 me thod. Results Varied chemical disinfectants had different metal R valu e. R value was in fluenced by kinds of metal pieces, sorts of soaked vessel material, drying tempe rature, whether changing liquid disinfectants or not and water quality, while d ifferent capacity of balance measure had no effect on R value. Concl usi ons R value was affected by kinds and types of metal pieces and other factors. These fac tors should be considered sufficiently while determining or comparing corrosiven ess of chemical disinfectants to soaked metal.
10.The role of DR5 in TRAIL-induced apoptosis for Jurkat cell line
Yuanfang MA ; Dongliang YANG ; Shixin LU ; Youhai CHEN
Chinese Journal of Immunology 1985;0(05):-
Objective:To study the role of DR5 in TRAIL apoptotic signal transduction. Methods:BALB/C mice were immunized with recombinant DR5 that contains the full-length extracellular domain of the human DR5. Anti-DR5 mAb was generated by hybridoma. The level of DR5 expression on Jurkat cell line was examined by flow cytometry. The rates of TRAIL-induced apoptosis and anti-DR5 mAb blocking on Jurkat cells were tested by flow cytometry with TRAIL apoptosis kit.Results:The percentage of DR5 expression on Jurkat cells was 94 83%. TRAIL and anti-TRAIL mAb could kill Jurkat cells on dose-dependent, and the killing rate was 90% in the concentration of 50~100 ng/ml. The killing role of TRAIL could be blocked on Jurkat cells pretreated with anti-DR5 mAb. The average percentage of blocking was 90 49%.Conclusion:DR5 plays a very key role in TRAIL induced apoptosis in Jurkat cells.