Abstract In order to understand the intergenerational impact of parental childhood trauma on development of adolescent depression disorder and its mechanism, the study comprehensively elaborates possible mechanisms underlying association between parental childhood trauma and adolescent depressive disorders from multiple levels based on the biopsychosocial integrative medicine model. Future research is needed to further clarify possible mechanisms in an integrated model. Preventive and intervention measures can be proposed and early block the malignant of intergenerational influence of childhood trauma.