1.Cheese-like Material in the Heart: An Autopsy Case Report of Severe Hypertriglyceridemia in Diabetic Ketoacidosis Patient.
Joo Young NA ; Eun Hee KIM ; Bon Young KOO ; Ik Jo CHUNG ; Byung Ha CHOI ; Nak Eun CHUNG
Korean Journal of Legal Medicine 2013;37(4):212-215
Here we report an autopsy case of diabetic ketoacidosis (DKA) with severe hypertriglyceridemia (12,900 mg/dl). A 29-year-old woman with a history of type 1 diabetes was found dead at a motel. There was no injury on external inspection, but a lump of cheese-like material was noted in the heart at autopsy and peripheral blood plasma had a creamy appearance. After postmortem biochemical analysis, we made a diagnosis of DKA with severe hypertriglyceridemia and concluded that these unusual autopsy findings were caused by DKA and postmortem change. Uncontrolled diabetes often causes DKA and hypertriglyceridemia. To the best of our knowledge, this is the first report in Korea of DKA with severe hypertriglyceridemia diagnosed by autopsy.
Adult
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Autopsy*
;
Diabetic Ketoacidosis*
;
Diagnosis
;
Female
;
Heart*
;
Humans
;
Hypertriglyceridemia*
;
Korea
;
Plasma
;
Postmortem Changes
2.One case of Infectious Mononcleosis.
Kyung Sook CHO ; Do Keum NA ; Byung Gyu KIM ; Sook Hyeon YUN ; Jong Dae JO ; In Sun JEON
Journal of the Korean Pediatric Society 1981;24(9):872-876
A case of infectious mononucleosis was presented. She was admitted to the hospital with the anterior cervical lymphadenopathy. Erythematous skin rashes on both low extermities, and splenomegaly. Her chief complaints were fever and sore throat. She showed atypical lymphocytes in peripheral blood smear with relative lymphocytosis. Mono-spot test was positive. She received symptomatic therapy and discharged without any complications. So, we report this case and review the brief literatures of infectious mononucleosis with the respect to etiology, clinical course, and histological characteristics of the disease.
Exanthema
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Fever
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Infectious Mononucleosis
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Lymphatic Diseases
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Lymphocytes
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Lymphocytosis
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Pharyngitis
;
Splenomegaly
3.Inhibition of ovarian carcinoma growth in nude by administration of gonadotropic hormone-releasing hormone analog.
Jin Woo KIM ; Byung Heun JEUNG ; Jong Ku NA ; Dae Hoon KIM ; Sung Eun NAMKOONG ; Seung Jo KIM ; Hun Young LEE
Korean Journal of Obstetrics and Gynecology 1992;35(12):1779-1789
No abstract available.
4.Campylobacter Enteritis: Clinical Features and Laboratory Findings in Children Treated at a Single Hospital
Won Tae JANG ; Na Hyun JO ; Mi Ok SONG ; Byung Wook EUN ; Young Min AHN
Pediatric Infection & Vaccine 2019;26(1):22-31
PURPOSE: Campylobacter species are common causes of bacterial enteritis. There is limited knowledge on its prevalence and clinical features because of its fastidious culture conditions. The purpose of this study was to identify the clinical features of Campylobacter enteritis in children. METHODS: We obtained stool specimens from patients diagnosed with acute gastroenteritis in the Department of Pediatrics, Nowon Eulji Medical Center (NEMC) and identified the pathogens by performing cultures or polymerase chain reactions (PCR). We retrospectively reviewed the medical records of patients with Campylobacter enteritis at NEMC between January 2012 and December 2017. RESULTS: Overall, 123 patients were diagnosed with Campylobacter enteritis (60 by culture and PCR in EnterNet and 110 by multiplex PCR). The median (interquartile range [IQR]) age of patients was 12 years (IQR, 8 to 16 years). The disease occurred all year round, but 69.9% from June to September. Symptoms included diarrhea (97.6%), fever (96.7%), abdominal pain (94.3%), vomiting (37.4%), and headache (34.1%). Compared with other treatments, treatment with azithromycin was associated with a shorter hospitalization period (P<0.05). CONCLUSIONS: Campylobacter enteritis is common during summer and mostly infects adolescent patients. It causes severe abdominal pain and fever preceding the onset of diarrhea. Prompt diagnosis and appropriate use of antibiotics reduces the duration of the disease.
Abdominal Pain
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Adolescent
;
Anti-Bacterial Agents
;
Azithromycin
;
Campylobacter
;
Child
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Diagnosis
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Diarrhea
;
Enteritis
;
Fever
;
Gastroenteritis
;
Headache
;
Hospitalization
;
Humans
;
Medical Records
;
Pediatrics
;
Polymerase Chain Reaction
;
Prevalence
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Retrospective Studies
;
Vomiting
5.Spontaneous Dissolution of Isolated Superior Mesenteric Vein Thrombosis in Acute Pancreatitis.
Byung Soo NA ; Byung Min JOHN ; Ki Bum KIM ; Je Soo LEE ; Hyun Woo JO ; Chang Hyeon SEOCK ; Dong Hui KIM ; Ki Sung LEE
The Korean Journal of Gastroenterology 2011;57(1):38-41
Acute pancreatitis can result in many vascular complications in both artery and vein. Venous complication usually occurs as a form of splenic or portal vein thrombosis, and also can simultaneously occur in superior mesenteric vein as well. Rarely, isolated superior mesenteric vein thrombosis occurs as a venous complication. Although it is uncommon, mesenteric vein thrombosis is an important clinical entity because of the possibility of mesenteric ischemia and infarction of small bowel. The treatments of mesenteric venous thrombosis include anticoagulation therapy, transcatheter therapy and surgical intervention. We report a case of 45-year-old man who had acute pancreatitis with isolated superior mesenteric vein thrombosis, which was spontaneously dissolved with the resolution of underlying inflammation without anticoagulation or surgical intervention.
Acute Disease
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Humans
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Male
;
*Mesenteric Veins
;
Middle Aged
;
Pancreatitis/complications/*diagnosis
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Tomography, X-Ray Computed
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Venous Thrombosis/*diagnosis/etiology/radiography
6.A Case of Duodenal Diverticulitis.
Chang Hyeon SEOCK ; Hae Kyung KIM ; Tae Il PARK ; Byung Min JOHN ; Hyeon U JO ; Jae Seung KIM ; Kee Bum KIM ; Byung Soo NA
Korean Journal of Gastrointestinal Endoscopy 2010;41(5):294-297
Duodenal diverticulitis is difficult to diagnose because it can mimic other common diseases such as cholecystitis and perforated ulcer. Recently, we experienced a rare case of duodenal diverticulitis that was initially suspected on abdominal computed tomography as focal pancreatitis. Although duodenal diverticulitis has been increasingly recognizable before surgery, with the advent of multi-detector computed tomography, misdiagnosis remains problematic since duodenal diverticulitis is commonly not considered in the differential diagnosis of acute abdominal pain. We have to consider this rare disease entity because delayed diagnosis might be a cause of substantial morbidity and mortality.
Abdominal Pain
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Cholecystitis
;
Delayed Diagnosis
;
Diagnosis, Differential
;
Diagnostic Errors
;
Diverticulitis
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Diverticulum
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Duodenum
;
Hydrazines
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Pancreatitis
;
Rare Diseases
;
Ulcer
7.Reliability for Multiple Reviewers by using Loglinear Models.
Byung Joo PARK ; Sung Im LEE ; Young Jo LEE ; Dong Hyun KIM ; Ho Jang KWON ; Jong Myon BAE ; Myung Hee SHIN ; Mi Na HA ; Sang Whan HAN
Korean Journal of Preventive Medicine 1997;30(4):719-728
To guarantee the inter-reviewer reliability is very important in evaluating the quality of large number of clinical research papers by multiple reviewers. We cannot find reports on statistical methods for evaluating reliability for multiple raters in clinical research field. The purpose of this paper is to introduce the statistical methods focused on kappa statistic and five kinds of loglinear models for, which can be applied when evaluating the reliability of multiple raters. We have applied these methods to the result of a project, in which seven reviewers have evaluated the quality of 33 papers with regard to four aspects of paper contents including study hypothesis, study design, study population, study method, data analysis and interpretation. Among the five loglinear models including Symmetry model, Conditional symmetry model, Quasi-symmetry model, Independence model, and Quasi-independence model, Quasi-symmetry model shows the best model of fitting. And the level of reliability among seven reviewers revealed to be acceptable as meaningful.
Statistics as Topic
8.Long-term follow-up of Fanconi anemia: clinical manifestation and treatment outcome.
Byung Gyu YOON ; Hee Na KIM ; Ui Joung HAN ; Hae In JANG ; Dong Kyun HAN ; Hee Jo BAEK ; Tai Ju HWANG ; Hoon KOOK
Korean Journal of Pediatrics 2014;57(3):125-134
PURPOSE: The aim of this study was to characterize Korean patients with Fanconi anemia (FA), which is a rare but very challenging genetic disease. METHODS: The medical records of 12 FA patients diagnosed at Chonnam National University Hospital from 1991 to 2012 were retrospectively reviewed. RESULTS: The median age at diagnosis was 6.2 years. All patients showed evidence of marrow failure and one or more physical stigmata. Chromosome breakage tests were positive in 9 out of 11 available patients. The median follow-up duration was 69.5 months. The Kaplan-Meier (KM) survival of all patients was 83.3% at 10 years and 34.7% at 20 years, respectively. Seven patients underwent 9 stem cell transplantations (SCTs). Among them, 5 were alive by the end of the study. Ten-year KM survival after SCT was 71.4% with a median follow-up of 3.4 years. All 5 patients treated with supportive treatment alone died of infection or progression at the median age of 13.5 years, except for one with short follow-up duration. Acute leukemia developed in 2 patients at 15.4 and 18.1 years of age. Among 6 patients who are still alive, 3 had short stature and 1 developed insulin-dependent diabetes mellitus. CONCLUSION: We provide information on the long-term outcomes of FA patients in Korea. A nation-wide FA registry that includes information of the genotypes of Korean patients is required to further characterize ethnic differences and provide the best standard of care for FA patients.
Bone Marrow
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Christianity
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Chromosome Breakage
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Diabetes Mellitus, Type 1
;
Diagnosis
;
Fanconi Anemia*
;
Follow-Up Studies*
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Genotype
;
Humans
;
Jeollanam-do
;
Korea
;
Leukemia
;
Medical Records
;
Retrospective Studies
;
Standard of Care
;
Stem Cell Transplantation
;
Treatment Outcome*
9.Efficacy of prolonged entecavir monotherapy in treatment-naive chronic hepatitis B patients exhibiting a partial virologic response to entecavir.
Han Na CHOI ; Jeong Eun SONG ; Hyeon Chul LEE ; Hyeong Ho JO ; Chang Hyeong LEE ; Byung Seok KIM
Clinical and Molecular Hepatology 2015;21(1):24-31
BACKGROUND/AIMS: The optimal management of patients exhibiting a partial virologic response (PVR) to entecavir (ETV) has not been determined . The aim of this study was to determine the long-term efficacy of prolonged ETV monotherapy in treatment-naive chronic hepatitis B (CHB) patients exhibiting a PVR to ETV therapy. METHODS: This study included 364 treatment-naive CHB patients treated with ETV for > or =48 weeks and who received continuous ETV monotherapy for > or =96 weeks. PVR was defined as a decrease in serum hepatitis B virus (HBV) DNA of more than 2 log10 IU/mL from baseline but with detectable HBV DNA by real-time PCR assay at week 48. RESULTS: Fifty-two of the 364 patients (14.3%) showed a PVR. Among them, 41 patients received continuous ETV monotherapy for > or =96 weeks (median duration 144 weeks, range 96-312 weeks), and 40 of these patients (95%) achieved a virologic response (VR, HBV DNA <20 IU/mL) during prolonged ETV monotherapy (median duration 78 weeks, range 60-288 weeks). The cumulative probabilities of a VR at weeks 96, 144, and 192 from treatment initiation were 78.0%, 92.7%, and 95.1%, respectively. The VR rate was 97.2% (35/36) in HBeAg-positive patients and 100% (5/5) in HBeAg-negative patients. In multivariate analysis, HBeAg positivity (odds ratio [OR], 9.231; 95% confidence interval [CI], 1.03-82.91; P=0.047) and a high baseline HBV DNA level (OR, 0.170; 95% CI, 0.08-0.37; P=0.000) were independently associated with a delayed virologic response. No patient developed genotypic resistance to ETV during follow-up. CONCLUSIONS: Long-term ETV monotherapy is effective for achieving a VR in treatment-naive CHB patients exhibiting a PVR to ETV. HBeAg positivity and high baseline HBV DNA level were independently associated with a delayed virologic response.
Adult
;
Aged
;
Antiviral Agents/*therapeutic use
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DNA, Viral/blood
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Drug Administration Schedule
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Female
;
Genotype
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Guanine/*analogs & derivatives/therapeutic use
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Hepatitis B e Antigens/blood
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Hepatitis B virus/genetics
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Hepatitis B, Chronic/*drug therapy/pathology/virology
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Humans
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Liver Cirrhosis/etiology/radiography/ultrasonography
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Magnetic Resonance Imaging
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Male
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Middle Aged
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Multivariate Analysis
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Odds Ratio
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Real-Time Polymerase Chain Reaction
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Retrospective Studies
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Tomography, X-Ray Computed
;
Treatment Outcome
10.Patient with Malignant Granular Cell Tumor Treated with Sunitinib Malate.
Su Jin LEE ; Ji Hyun KIM ; Hyun Wook CHO ; Gyeong Jae NA ; Han Jo KIM ; Sang Byung BAE ; Kyu Taek LEE
Soonchunhyang Medical Science 2012;18(1):66-69
Malignant granular cell tumors (MGST) are extremely rare, high-grade sarcoma of schwann cell origin. They often metastasize and are associated with short survival. We described a patient with recurred MGST after wide marginal excision followed by chemotherapy. The histologic findings revealed relapsed MGST containing rich vascular structure. The patient was treated with sunitinib malate (50 mg/day) for three weeks. Because sunitinib malate has a potent antiangiogenic property, we surmised that it might be effective against this type of malignancy. However, he died due to progression of tumor after six weeks. Here, we report it along with the corresponding literature.
Granular Cell Tumor
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Humans
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Indoles
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Pyrroles
;
Sarcoma