Vascular dementia is defined as a clinical syndrome of acquired intellectual impairment resulting from a brain injury due to a cerebrovascular disorder. It incorporates various vascular pathophysiological mechanisms and changes in the brain, and has diverse cause and clinical manifestations. The main suptypes of vascular dementia include 1) multi-infarct dementia, 2) strategic infarct dementia, and 3) subcortical vascular dementia. Both multi-infarct dementia and strategic infarct dementia show heterogeneity in etiologies, changes of the brain, as well as clinical manifestations. On the contrary, subcortical vascular dementia is suggested to be a more homogenous group. To better understand the clinical features of vascular dementia, cases corresponding to each subtype of vascular dementia are briefly discussed this review.
Brain ; Brain Injuries ; Cerebrovascular Disorders ; Dementia ; Dementia, Multi-Infarct ; Dementia, Vascular* ; Population Characteristics

Stroke is one of the leading causes of death in Korea. According to the report from Korean national statistical office, the mortality rate of stroke was 73.2/100,000 persons in 2000. In Western countries, stroke mortality rates declined gradually from 1970, which accelerated markedly around 1990. Since then, there has been no further decrease in stroke mortality rates until now and the situation has been similar in Korea. In the past, hemorrhagic stroke in Korea similar to other Far East Asian countries. However, the ratio of hemorrhagic to ischemic stroke has been reversed since mid-1980s. This trend might be due to the westernization of diet and life style as well as better control of hypertension. The case fatality rate from one of the large hospital-based stroke registry was 7.2% within 30 days after the onset of acute ischemic stroke, which is similar to those of other series from western countries with an advanced medical care systems. It may be attributed to the inclusion of more asymptomatic or milder patients with small lesions detected by neuroimaging. Importantly, the delay of hospital visit after the onset of stroke and the lower compliance for secondary prevention remain serious problems in managing acute stroke in Korea. Despite recent advances in the diagnosis and management of stroke, there has not been a nationwide population-based epidemiologic data on stroke in Korea. Therefore the application of Internet technology to develop multi center cooperative hospital-based registry could be an important step toward a long-waited nationwide stroke registry.
Asian Continental Ancestry Group ; Cause of Death ; Compliance ; Diagnosis ; Diet ; Epidemiology* ; Far East ; Humans ; Hypertension ; Internet ; Korea* ; Life Style ; Mortality ; Neuroimaging ; Secondary Prevention ; Stroke*

No abstract available.
Intestinal Fistula*

No abstract available.
Child* ; Fetal Growth Retardation* ; Growth Hormone* ; Humans

Apert's syndrome is an uncommon, congenital disturbance in the growth of bone and soft tissue affecting principally the head, the hands and the feet. So there is skull malformation, most often oxycephaly, associated with malformation of both hands and feet. This syndrome was first reported by Apert in 1906. Since that time, over 200 cases have been reported. Recently we have experienced two cases of typical Apert's syndrome. We made a brief literature review.
Craniosynostoses ; Foot ; Hand ; Head ; Skull

No abstract available.
Pancreatic Pseudocyst*

No abstract available.
Colon* ; Rectum*

No abstract available.
Hemorrhage*

This relatively uncommon malignant melanoma (incidence less than 5/100, 000 population) is attested to by the fact that despite accounting for only 3% of all cutaneous malignant neoplasms and causes 67% of the deaths attributabIe to skin cancer. Sunlight pIays a major role in. the development of melanoma. Several factors influence the clinical course of malignant melanoma, such as sex, site, type of ma1ignant melanoma, degree of cellular anaplasia, inflammatory reaction and thickness of the lesion. Two caees of malignant melanoma were presented. The one was 55 year old male who had been suffered from large pea sued blackish ulcerative lesion on the lft sole aince 3 years before. The other one was 66 year old female wha had been suffered frorn walnut sized ulcerative lesion on the right inner wrist joint with regional lymph adenopathy since 2 yea,ra before. The patient was treated with wide surgical excision, regionaI lymphnode dissection and subcutaneous injection with Tubercin-3. The first male patient was treated completely but second female patient shows recurrence of the lesion on the right forearm and upper arm within 40 days.
Aged ; Anaplasia ; Arm ; Female ; Forearm ; Humans ; Injections, Subcutaneous ; Juglans ; Male ; Melanoma* ; Middle Aged ; Peas ; Recurrence ; Skin Neoplasms ; Sunlight ; Ulcer ; Wrist Joint

Clinical characteristics of 336 infants referred for chromosomal study during neonatal period from Jan. 1985 to Dec. 1994 to the cytogenetic laboratory of St. Mary's Hospital, Catholic University Medical College were reviewed. Karyotypes were analysed from peripheral blood lymphocyte cultures and G-banding was carried out. A thorough survey of the clinical reasons for chromosomal analysis, prevalence of chromosomal abnormalities in each disease category, and the patterns of chromosomal aberrations were done. The results were as follows, 1) Down syndrome was the most common indication for chromosome analysis in the newborn period, consisting of 37.8 % of all cases referred. Other indications included skeletal anomaly, multi-organ anomalies, cleft lip/palate, ambiguous genitalia, odd looking face, gastrointestinal anomaly, central nervous system anomaly, and Turner syndrome. 2) Overall in 42.9 percent of cases referred, chromosomal abnormalities was found. 3) 1'he percentage of final diagnosis in suspected Down syndrome was 85.0 #96. Overall, of the non-Down syndrome cases, 16.7 96 was given a definitive diagnosis of chromosomal abnomality. In each disease category, 57.1 % of suspected Turner syndrome and 37.2 % of multi-organ anomalies had been proved having chromosomal abnormalities. The percentages of chromosomal aberrations in isolated odd looking face, ambiguous genitalia, and skeletal anomaly were relatively low, around 5 %. None of the newborns referred because of cleft lip/palate, congenital anomalies of gastrointestinal tract or central nervous system had abnormal karyotype. 4) 95.1 % of all cases diagnosed to have chromosomal abnormality had autosomal aberrations, the remainder 4.9 % had sex chromosomal aberrations. 5) Trisomy 21 was the most common numerical aberrations of autosomes, consisting of 87.5 % and trisomy 18, trisomy 13, and mosaicism was 7.1 %, 3.6 96 and 1.8 % of total. 6) 90.7 % of Down syndrome were due to trisomy 21, the rest being translocation (7.4 %) and mosaicism (1.9 %).
Abnormal Karyotype ; Central Nervous System ; Chromosome Aberrations ; Cytogenetics ; Diagnosis ; Disorders of Sex Development ; Down Syndrome ; Gastrointestinal Tract ; Humans ; Infant ; Infant, Newborn* ; Karyotype* ; Lymphocytes ; Mosaicism ; Prevalence ; Trisomy ; Turner Syndrome