Primary malignant lymphoma of lung is a very rare disease, only 0.34% of all malignant lymphomas. In our case, a 76 year old male patient had a solitary mass without lympha-denopathy at chest CT scan. He underwent right middle lobectomy through a posterolateral thoracotomy incision. Pathologic study confirmed a diagnosis of malignant lymphoma and chemotherapy was started by an oncologist.
Aged ; Diagnosis ; Drug Therapy ; Humans ; Lung Neoplasms ; Lung* ; Lymphoma* ; Male ; Rare Diseases ; Thoracotomy ; Tomography, X-Ray Computed

Actinomycosis, a rare disease entity in the upper genital tract, and caused by anaerobic bacteria, Actinomyces israelii, presents some difficulties in establishing a correct preoperative diagnosis. Pelvic actinomycosis has been reported more frequently in women with intrauterine device (IUD). Actinomycosis may be confused with malignancy and other inflammatory diseases due to its infiltrative nature and tendency to invade normal anatomic barriers. So, cervicovaginal smear is recommended for all women wearing IUDs, and actinomyosis should be suspected in such patients suffering pelvic infections. We experienced a case of pelvic and abdominal actionomycosis complicated by tuboovarian abscess in a 52 year-old woman wearing IUD and report it with a brief review of related literatures.
Abscess ; Actinomyces ; Actinomycosis* ; Bacteria, Anaerobic ; Diagnosis ; Female ; Humans ; Intrauterine Devices* ; Middle Aged ; Pelvic Infection ; Rare Diseases

Fifty nine patients who had been admitted to Seoul National University Hospital from April to October in 1986 were prospectively examined by a pulsed Doppler echocardiography on one day before cardiac catheterization. The sample volume was placed both just proximal and distal to pulmonic valve on 2-D echocardiogram. 1) Among the three morphologic patterns of the flow velocity, triangular and intermediate types indicate pulmonary hypertension (sensitivity 84%, specificity 86%), and round type indicates normal pulmonary arterial pressure (sensitivity 86%, specificity 84%). 2) In the group with pulmonary hypertension acceleration time and ejection time were measured shorter (P<0.01), and prejection period was measured longer than the group without pulmonary hypertension (P<0.05). 3) The best correlation was obtained between PEP/AT and mean pulmonary arterial pressure (r=0.77). Acceleration time alone also correlated well with mean arterial pulmonary pressure(r=-0.69). 4) In STI measurement and its correlation with pulmonary arterial pressure, no significant difference was observed when recorded in main pulmonary artery or right ventricular outflow tract. But in the latter position, late, systolic fluttering and variation in curve morphology occured less likely. 5) Our results indicate that the pulsed Doppler echocardiography is useful not only in the diagnosis of pulmonary hypertension but also in the quantitative estimation of pulmonary arterial pressure in different heart diseases. Futhermore this method may be a good tool for follow-up evaluation after surgical or medical treatment of patients with pulmonary hypertension.
Acceleration ; Arterial Pressure* ; Cardiac Catheterization ; Cardiac Catheters ; Diagnosis ; Echocardiography, Doppler ; Echocardiography, Doppler, Pulsed* ; Heart Diseases ; Humans ; Hypertension, Pulmonary ; Prospective Studies ; Pulmonary Artery ; Sensitivity and Specificity ; Seoul

PURPOSE: Severe burn injury produces a catabolic state and several studies have evaluated the efficacy of recombinant human growth hormone (rhGH, GH) in burn treatment. This study aimed to investigate whether GH administration in severely burned patients can reverse or attenuate the catabolic state and can increase the serum level of insulin-like growth factor-I (IGF-I). The study also evaluated the efficacy of the early use of GH in major burn patients. METHODS: A randomized, controlled trial was carried out with 39 patients with severe burns (more than 40% of the total body surface burned or more than 20% full-thickness burns), of whom 24 completed the study protocol and were analysed. Fourteen patients received standard conservative treatment only, while the other 10 additionally received GH (0.1 mg/kg/day) over 3 weeks. Urinary urea nitrogen (UUN), transferrin, total body surface area burned (TBSAB) and IGF-I were measured. RESULTS: Additional GH treatment resulted in a significantly changed ratio (%) of UUN (P=0.010, P=0.011) and transferrin (P=0.012, P=0.031) at 1 week and 2 weeks, compared to no-GH treatment. These parameters showed significant change during the study period within the GH group. Furthermore, GH treatment showed a 3-fold elevation in IGF-I, while no-GH treatment did not show any significant change (P=0.021). TBSAB was decreased significantly in GH treatment compared to no-GH treatment at 2 weeks (P=0.046), but there was no significant difference at 1 week and 3 weeks. CONCLUSION: These results indicate that GH attenuates thecatabolic state and that short-term GH treatment in addition to standard burn treatment appears to have benefits for severely burned patients.
Body Surface Area ; Burns* ; Growth Hormone ; Human Growth Hormone* ; Humans ; Insulin-Like Growth Factor I ; Nitrogen ; Transferrin ; Urea

OBJECTIVE: Hypoxic conditions are thought to be exist in inflamed arthritic synovium.Several in vitro and in vivo studies indicate that hypoxia can initiate events that lead to pro-adhesive changes.Therefore,this study was designed to examine the effects of hypoxia on the expression of ICAM-1 by cultured human synovial fibroblasts. METHODS: Synovial fibroblasts were isolated from patients with RA and cultured at hypoxic condition.To quantify the expression of ICAM-1 mRNA in synovial fibroblasts,RT-PCR was performed.The levels of cytokines in culture supernatants were measured by ELISA.The activation of NF- Adhesives ; Anoxia* ; Cytokines ; Fibroblasts* ; Humans* ; Intercellular Adhesion Molecule-1* ; Interleukin-1 ; Lymphocytes ; RNA, Messenger ; Tumor Necrosis Factor-alpha