Restoration of functional and anatomic changes of kidney in UPJ stricture is one of most important subjects in urology. A clinical observation was made on the 28 cases (29 kidneys) of pyeloplasties for UPJ stricture from Jan. 1976 to Dec. 1981. Of them 20 cases (21 kidneys) were followed up for more than 6 months postoperatively. The following results were obtained; 1. The patients in this series were 22 males and 6 females, and 11 children and 17 adults. The left side was 3 times more frequently affected than the right. They symptoms on admission were mostly flank pain, palpable mass, and etc. 2. Preoperative status of UPJ was; UPJ stricture alone in 20, UPJ stricture with aberrant vessel in 4, UPJ stricture with stone in 3, and UPJ stricture with vesicoureteral reflux in 1 case. 3. Preoperative grade of hydronephrosis was closely related to each other in the functional and anatomic aspects of kidney. In general, children showed relatively more advanced hydronephrosis than adults and the degree of improvement of hydronephrosis postoperatively was similar to each other. 4. Anderson Hynes' method of pyeloplasty in most cases (20 kidneys) and simple pyeloureterostomy in 9 kidneys were performed, and results between both operations showed no difference. But Anderson Hynes' method was more effective in marked hydronephrosis such as giant hydronephrosis and simple pyeloureterostomy in mild hydronephrosis. 5. In cases in which UTI was present preoperatively, postoperative UTI tended more to persist than in those not complicated with preoperative UTI, and in both sides postoperative UTI mostly persisted for 2 months and disappeared within 6 months. 6. The period of nephrostomy and ureteral stent was not directly related to postoperative results, but nephrostomy without ureteral stent relatively showed good results. 7. Postoperative complication was UTI in 2, re-do pyeloplasty in 1 and secondary nephrectomy in 1 case. 8. Improvement Of hydronephrosis continued for about a year after operation. It is recommended that more careful attention should be paid for the first year and be continued to watch for consecutive 2 years.
Adult ; Child ; Constriction, Pathologic* ; Female ; Flank Pain ; Humans ; Hydronephrosis ; Kidney ; Male ; Nephrectomy ; Postoperative Complications ; Prognosis* ; Stents ; Ureter ; Urology ; Vesico-Ureteral Reflux

Dendritic cell (DC)s are protessional antigen presenting cells and they have been used for antitumor immunotherapy or cell vaccines. However therapy using DC is restricted because the number of DC available from tissue is very low. Flt3 ligand (FL) has been known as a hematopoietic growth factor that increases proliferation of hematopoietic stem cells and progenitor cells, and recently it showed inducibility of dendritic cell (DC)s and signiticant antitumor effects in vivo. Thus FL will be frequently used for DC induction and antitumor immunotherapy in future. Here we constructed FL plasmid and studied its in vivo effect. FL plasmids were made by cloning of partial FL cDNA into pcDNA3 plasmid, and gene expression and protein producibility of FL plasmid were confirmed in Renca cells transfected with FL plasmid. Mice were injected with FL plasmid (100ug/mouse) three times and 20 days later mouse spleens were harvested for staining and RT-PCR. There were lots of blastogenic cells in the spleen of mice treated with FL plasmid. FL plasmid also induced DEC205, IL-12 and GM-CSF gene expression in mouse splenocyte. All these data suggest FL plasmid may be used for induction of DC and antitumor therapy as DNA adjuvant.
Mice ; Animals

No abstract available.
Fever ; Humans ; Still's Disease, Adult-Onset* ; Urticaria*

No abstract available.
Wilms Tumor*

Crossed renal ectopia with fusion is an unusual congenital anomaly, probably produced by abnormal development of the ureteral bud. The deformity itself produces no symptoms but it presents possible urinary tract infection, obstuction and stone formation, and other anomaly in body. Herein we report two cases of crossed fused renal ectopia complained of abdominal mass in 28 year old female and abdominal pain after trauma in 14 year-old boy.
Abdominal Pain ; Adolescent ; Adult ; Congenital Abnormalities ; Female ; Humans ; Male ; Ureter ; Urinary Tract Infections

From October 1974 to September 1984, 64 consecutive patients of bladder and urethral cancer were treated by cystectomy and urinary diversion at the Department of Urology, Pusan National University Hospital. Comparative study was made between enteric diversion and ureterocutaneostomy, and several surgical mo. dality of cystectomy. The results obtained were as follows. l. The modes of cystectomy were simple cystectomy in 5 cases (7.8%), total cystectomy in 48 cases (75.0%), radical cystectomy in 10 cases (15.6%) and pelvic exenteration in 1 cases (1.6%). 2. The causes of cystectomy with urinary diversion were primary bladder cancer in 60 cases (93.8%), urethral carcinoma in 2 cases (3.1%) and metastatic bladder cancer in 2 cases (3.1%). 3. The methods of urinary. diversion were ileal conduit in 38 cases (59.4%) , ileocecal conduit in 5 cases (7.8%), tube in double stoma ureterocutaneostomy in 7 cases (10.9%) and tubeless single stoma ureterocutaneostomy in 14 cases (21.9%). 4. Age distribution was from 4 to 79 years and average was 56.3 years. Male to female ratio was 7:l. 5. Most frequent urinary diversion was enteric in 6th decade and ureterocutaneostomy in 7th decade. 6. Average operation time was 360 minutes in enteric diversion with total cystectomy and 272 minutes in ureterocutaneostomy with total cystectomy. 7. High stage (>=pT2) was 76.5% in enteric diversion and 81.O% in ureterocutaneostomy. High grade (II or III) was 67.6% in enteric diversion and 81.0% in ureterocutaneostomy. 8. Early complication rates were 50.0% in ileal conduit, 60.0% in ileocecal conduit, 42.9% in tube in double stoma ureterocutaneostomy, and 35.7% in tubeless single stoma ureterocutaneostomy. Late complication rates were 52.4% in ileal couuit, 40.0% ileocecal conduit and 33.3% in tubeless single stoma ureterocutaneostomy. 9. Local recurrence of tumor was observed in 80.0% of simple cystectomy cases but recurrence was not in total or radical cystectomy. Conclusively, total or radical cystectomy is treatment of choice in invasive bladder tumor rather than simple cystectomy. And single stoma ureterocutaneostomy may be useful method of urinary diversion inhigh stage, high grade, aged and poor risk patient if stomal control is male carefully.
Age Distribution ; Busan ; Cystectomy* ; Female ; Humans ; Male ; Pelvic Exenteration ; Recurrence ; Urethral Neoplasms ; Urinary Bladder ; Urinary Bladder Neoplasms ; Urinary Diversion* ; Urology

No abstract available.
Neurothekeoma* ; Scalp*

Three patients have successfully undergone ureteroneoystostomy with submucosal tunneling as an antirefluxing measure using vesico-psoas hitch procedure for extensive postoperative stricture of the lower ureter. Postoperatively, none of the patients has developed ureterovesical stenosis, and functional capacity of the bladder has been well preserved despite of extensive mobilization. In one patient reflux has occurred through the ureteral orifice of the opposite side. Since the technique of vesico-psoas hitch procedure is simply to mobilize the bladder and to fix its posterolateral corner to the psoas muscle, we believe that it provides a safer alternative to more complicated and potentially dangerous procedures.
Constriction, Pathologic* ; Humans ; Psoas Muscles ; Ureter* ; Urinary Bladder

No abstract available.
Fallopian Tubes* ; Female ; Mucous Membrane* ; Sterilization*

The records of 56 consecutive patients with bladder tumor were evaluated for correlation of preoperative cytological findings with endoscopic findings, pathological grade and stage from January, 1983 to June, l985 at the department of Urology, Pusan National University Hospital The cyto1ogical results of urine were influenced by pathological grade, stage and shape of the tumor. There was a significant increase in the number of negative urine cytology according to the decrease of grade and stage. We suggest that class I, II, III results of urine cytology with bladder tumor are usually associated with low grade or low stage (superficia1) tumor.
Busan ; Humans ; Urinary Bladder Neoplasms* ; Urinary Bladder* ; Urology