1.A Case of Virilizing Adrenal Cortical Carcinoma.
Seung Chul YANG ; Jin Wook CHOI ; Moon Young SONG ; Byung Kyu SUH ; Byung Churl LEE
Journal of Korean Society of Pediatric Endocrinology 1997;2(2):248-254
Adrenal cortical carcinoma is a rare disease both in adults and in children. Most of these tumors are functional, especially in children, producing endocrine syndromes such as virilization, Cushing syndrome, hyperaldosteronism or feminization. We experienced a case of adrenal cortical carcinoma in a 7yr old boy who showed features of virilization such as rapid growth rate, penile enlargement, and pubic hair. This case was diagnosed with typical hormonal findings and abdominal MRI and confirmed by pathologic findings. He was successfully treated by total left adrenalectomy and has been followed up without problem over eight months.
Adrenalectomy
;
Adrenocortical Carcinoma*
;
Adult
;
Child
;
Cushing Syndrome
;
Feminization
;
Hair
;
Humans
;
Hyperaldosteronism
;
Magnetic Resonance Imaging
;
Male
;
Rare Diseases
;
Virilism
2.Influence of Menstrual Cycle on Cystometry.
Sang Wook BAI ; Byung Ha CHUNG ; Seung Chul YANG ; Moo Sang LEE ; Sang Won PARK ; Jae Wook KIM
Korean Journal of Obstetrics and Gynecology 1998;41(11):2835-2838
Alteration in the hormone level associated with menstrual cycle influences the interaction between the urethra and bladder as well as detrusor function, maybe due to the common embryological origin of lower female genital and urinary tract. We tried to investigate the effect of the menstrual cycle on cystometric diagnosis through this retrospective study. 60 women with regular menstruation were enrolled in this study. The study groups were divided into 2 groups, Group I was women whose symptoms were not influenced by the menstrual cycle, Group II was women whose symptoms were adversely affected premenstrually. The majority of normal cystometric diagnosis were made in the luteal phase (Group I: 42.9% vs 4.4%, p<0.05; Group II: 50.0% vs 22.2%, p<0.05). But diagnosis of genuine stress incontinence, detrusor instability, mixed genuine stress incontinence and detrusor instability were frequently made in the follicular phase of mentruation. Normal cystometric diagnosis in the group II were more commom than the group II ( 36.8% vs 19.7%, p<0.05 ). The results of this study reveal that the timing of cystometric evaluation may influence the the detection of a positive diagnosis. In patients whose symptom are influenced by their menstrual cycle, the luteal phase may not be the correct time to make an accurate diagnosis.
Diagnosis
;
Female
;
Follicular Phase
;
Humans
;
Luteal Phase
;
Menstrual Cycle*
;
Menstruation
;
Retrospective Studies
;
Urethra
;
Urinary Bladder
;
Urinary Tract
3.A Case of Nasopharyngeal Papillary Adenocarcinoma: Nasal Endoscopic Approach.
Byung Wook YANG ; Min Ju PARK ; Byung Hoon AHN
Korean Journal of Otolaryngology - Head and Neck Surgery 2011;54(6):423-426
Low-grade nasopharyngeal papillary adenocarcinoma is an unusual nasopharyngeal tumor. This malignant tumor originates in the epithelium and exhibits adenocarcinomatous differentiation and indolent behavior. Macroscopically, these tumors are pedunculated polypoid masses that arise on the roof of the nasopharynx. Microscopically, they are characterized by papillary and glandular epithelial proliferation. We report a case of a 25-year-old woman who presented with a papillary adenocarcinoma on the roof of nasopharynx; in describing the case, we have focused on the histological features and endoscopic management of the tumor. The tumor was completely excised via nasal endoscopic approach. Immunohistochemical analysis of the tumor was performed based on a differential diagnosis of metastatic papillary thyroid carcinoma. The testing involved thyroid transcription factor-1, thyroglobulin, and epithelial membrane antigen analysis. The patient remained disease-free for over 6 months after the surgical excision performed via nasal endoscopic approach.
Adenocarcinoma, Papillary
;
Adult
;
Carcinoma
;
Diagnosis, Differential
;
Epithelium
;
Female
;
Humans
;
Mucin-1
;
Nasopharynx
;
Thyroglobulin
;
Thyroid Gland
;
Thyroid Neoplasms
4.Intermittent Rhythmic Delta Activity(IRDA) in Children.
Jong Wook KIM ; Byung Ho CHA ; Jae Seung YANG ; Baek Gun LIM
Journal of the Korean Child Neurology Society 1997;5(1):38-43
BACKGROUND: Intermittent rhythmic delta activity (IRDA) is classified as a nonspecific abnormal EEG pattern. IRDA is clinically associated with alteration of consciousness, hydrocephalus, cerebral edema, deep midline lesions, subcortical lesions, and tumors of the posterior fossa and the third ventricle. Frontal IRDA(FIRDA) is usually seen in patients over age 15 years, whereas occipital IRDA(OIRDA) occurs mainly in children. We have investigated the clinical feature and significance of IRDA in children. SUBJECTS AND METHODS: We retrospectively reviewed the medical records of 36 children with IRDA of EEG concerning diagnosis, neurologic examination, classification of epilepsy, and CT & MRI findings. RESULTS: 1) The location of the IRDA was frontal(FIRDA) in 11 of 36(30.5%), occipital(OIRDA) in 20 of 36(55.6%) and mixed in 5 of 36(13.9%) patients. 2) Thirty of 36(83.3%) have epilepsy (including 1 each with MELAS and tuberous sclerosis), 4 of 36(11.1%) have migraine and 2 of 36(11.1%) patients have meningitis. 3) Sixteen of 30(53.3%) have partial or partial with secondary generalized seizure, 10 of 30(33.3%) have generalized seizure and 4 of 30(13.3%) patients with epilepsy have absence seizure. 4) Neuroimaging studies (CT or MRI scan) were performed in 27 cases. Among 27 cases of studies, 6 cases(22.2%) were abnormal including; two cases of infections, and each case of infarction, venous angioma, arachnoid cyst, cortical atrophy, and tuberous sclerosis, respectively. CONCLUSIONS: IRDA may be considered an epileptiform pattern in childhood and FIRDA is frequently seen in children than previous reports.
Arachnoid
;
Atrophy
;
Brain Edema
;
Child*
;
Classification
;
Consciousness
;
Diagnosis
;
Electroencephalography
;
Epilepsy
;
Epilepsy, Absence
;
Hemangioma
;
Humans
;
Hydrocephalus
;
Infarction
;
Magnetic Resonance Imaging
;
Medical Records
;
MELAS Syndrome
;
Meningitis
;
Migraine Disorders
;
Neuroimaging
;
Neurologic Examination
;
Retrospective Studies
;
Seizures
;
Third Ventricle
;
Tuberous Sclerosis
5.The Clinical Study on Ipsilateral Fracture of the Femur and Tibia
Chang Uk CHOI ; Byung Il LEE ; Jae Wook KWON ; Man Sik YANG ; Seung Kyu PARK
The Journal of the Korean Orthopaedic Association 1990;25(5):1333-1340
The "flosting knee" is the term applied to the flail knee joint segment resulting from a fracture of the shaft of adiacent metanhysis of the ipsilateralfemur and tibia. The various methods of treatment of the "floating knee" were adapted by many authors according to degree of the comminution, degree of the soft tissue injury, general condition state of the fracture. Authors experienced the floating knee in 52 cases on 51 patients who were treated at Soon Chun Hyang University Hospital in the period of 4 years and 5 months from January 1985 to June 1989 and among them, 45 cases were treated by operative method and 7 cases by conservative methods at least one of the femur and tibia, The results were as follews;1. Floating Knee occured six times more in male and the peak age was third and fourth decades. 2. The most common cause of fractures was traffie aecident and there was difficulty in diagnosis of ligamentous disruption of the ipsilateral knee. 3. The common fracture site were middle one third and the most common fracture shape was comminuted in both femur and tibia. 4. A good or excellent functional result was aohieved in treated with open reduction and rigid fixation of both fracture and there were no significant difference in group of the internal fixation of both femur and tibia. 5. Intramedullary nailing on the femur and plate fixation on the tibia provided rigid fixation of fracture and the it made possible early joint motion exercise and ambulation and the average healing time of fracuture was much shortened. 6. The most common concomitant injury were soft tissue injury and delayed or nonuion and osteomyelitis were developed more frequently in the plate and screw fixation group of the open fracture.
Clinical Study
;
Diagnosis
;
Femur
;
Fracture Fixation, Intramedullary
;
Fractures, Open
;
Humans
;
Joints
;
Knee
;
Knee Joint
;
Ligaments
;
Male
;
Methods
;
Osteomyelitis
;
Soft Tissue Injuries
;
Tibia
;
Walking
6.Correlation between Androgenetic Alopecia and Lipid Parameters for Risk Factors of Coronary Artery Disease.
Seong Wook CHOE ; Yang Hyun YOON ; Byung In RO
Korean Journal of Dermatology 2004;42(10):1277-1284
BACKGROUND: The association of androgenetic alopecia and coronary artery disease has not been well documented although many studies have tried to reveal this association. This relationship is still a controversial issue. OBJECTIVES: The aim of this study is to investigate the association between the androgenetic alopecia and lipid parameters for risk factors of coronary artery disease. METHODS: The subjects of this study were 102 patients with androgenetic alopecia who had visited the Department of Dermatology, Pil-dong Hospital, College of medicine, Chung-Ang University during 2 years (from January 2000 to December 2001). The subjects of control group were 40 male individuals who had no androgenetic alopecia, no risk factor of coronary artery disease and no coronary artery disease. RESULTS: 1. There were significant differences in the serum total lipid, phospholipid, triglyceride between the patients and the control group. But there were no significant differences in serum LDL-cholesterol, HDL-cholesterol, and total cholesterol between the two groups. 2. There were significant differences in the serum total lipid, phospholipid, triglyceride between frontal baldness patients and the control group (p<0.05). But there were no significant differences in the serum LDL-cholesterol, HDL-cholesterol, and total cholesterol between the two groups. 3. There were significant differences in the serum total lipid, phospholipid, triglyceride, LDL-cholesterol, and total cholesterol between vertex baldness patients and the control group (p<0.05). But there were no significant differences in serum HDL-cholesterol between two groups. 4. There were no significant differences in the serum total lipid, phospholipid, triglyceride, LDL-cholesterol, HDL-cholesterol and total cholesterol between androgenetic alopecia patients who were increased serum testosterone and the control group. CONCLUSION: These data suggest that androgenetic alopecia involving the vertex scalp is associated with significantly increased total cholesterol and LDL-cholesterol for risk factors of coronary artery disease. We recommend that dermatologists should investigate the lipid parameters, especially total cholesterol and LDL-cholesterol in vertex baldness patients.
Alopecia*
;
Cholesterol
;
Coronary Artery Disease*
;
Coronary Vessels*
;
Dermatology
;
Humans
;
Male
;
Risk Factors*
;
Scalp
;
Testosterone
;
Triglycerides
7.Clinical Effects of E. cole Derived Authentic REcombinant Human Growth Hormone(DA-3002) in Children with Growth Hormone Deficiency.
Se Won YANG ; Byung Chul LEE ; Chul Woo KO ; Duk Hee KIM ; Han Wook YOO ; Woo Young CHUNG
Journal of Korean Society of Endocrinology 1998;13(4):526-535
BACKGROUND: Recently authentic human growth hormone(hGH) has produced in the E coli K-12, W3110 by recombinant DNA tecbnology in Korea In this paper, the clinical efficacy and immunogenicity of this GH was shdied in 38 children with growth hormone deficiency during therapy of 1 year. METHODS: The subjects of this study were aged 4.9-13.9 years, diagnosed by failure of plasma GH to respond to insulin-induced hypoglycemia, arginine and/or L-dopa loading and height below -2 standard deviation of mean for their chronological age. Each patient received GH 0.5-0.7IU/kg/week subcutaneously in 6-7 divided doses. During treatment, vital signs, height, body weight and bone age were checked every 3 months. Complete blood count, urinalysis, blood chemistry and thyroid hormone were checked before and every 6 months. The measurement of serum IGF-1 level and antibody against hGH were performed before and every 6 months during therapy of I year. RESULT: The height velocities significantly increased from 3.3 +/- 1.5cm/year to 10.1 +/- 2.5 and 9.0 +/- 1.8cm/year at 6 and 12 months of therapy, respectively. The height standard deviation score for chronological age were significantly improved from -2.141.50 to -1.74 +/- 1.43 and -1.54 +/- 1.38 at 6 and 12 months of therapy with increasing ratio of bone age to chronological age from 0.72 +/- 0.15 at pretreatment to 0.76 +/- 0.15 at 6 month, 0.79 +/- 0.16 at 12 month of therapy. The plasma IGF-1 level significantly increased during treatment. One of 36 patients(2.8%) showed positive antibody against hGH after 1 year of treatment. During therapy of 1 year, unwanted and remarkable clinical side effect were not observed in all subjects. CONCLUSION: These results indicate that this E. coli derived authentic recombinant growth hormone is very effective in stimulating linear growth in children with growth hormone deficiency.
Arginine
;
Blood Cell Count
;
Body Height
;
Chemistry
;
Child*
;
DNA, Recombinant
;
Escherichia coli
;
Growth Hormone*
;
Human Growth Hormone
;
Humans*
;
Hypoglycemia
;
Insulin-Like Growth Factor I
;
Korea
;
Levodopa
;
Plasma
;
Thyroid Gland
;
Urinalysis
;
Vital Signs
8.A case of meningoencephalitis due to streptococcus pneumoniae in a patients with chronic graft-versus-host disease after allogeneic bone marrow transplantation.
Byung Wook KIM ; Jin Hong YOO ; Wang Shik SHIN ; Yang Lee KIM ; Moon Won KANG ; Dong Wook KIM ; Jong Wook LEE ; Jong Won PARK ; Choon Choo KIM ; Dong Jib KIM
Korean Journal of Infectious Diseases 1993;25(3):271-275
No abstract available.
Bone Marrow Transplantation*
;
Bone Marrow*
;
Graft vs Host Disease*
;
Humans
;
Meningoencephalitis*
;
Streptococcus pneumoniae*
;
Streptococcus*
9.A case of meningoencephalitis due to streptococcus pneumoniae in a patients with chronic graft-versus-host disease after allogeneic bone marrow transplantation.
Byung Wook KIM ; Jin Hong YOO ; Wang Shik SHIN ; Yang Lee KIM ; Moon Won KANG ; Dong Wook KIM ; Jong Wook LEE ; Jong Won PARK ; Choon Choo KIM ; Dong Jib KIM
Korean Journal of Infectious Diseases 1993;25(3):271-275
No abstract available.
Bone Marrow Transplantation*
;
Bone Marrow*
;
Graft vs Host Disease*
;
Humans
;
Meningoencephalitis*
;
Streptococcus pneumoniae*
;
Streptococcus*
10.Clinical Evaluation of Posterior Chamber Intraocular lens Implantation in thee Eye Without Poosterior Capsular Support.
Hye Wook JEONG ; Hong Ki KIM ; Chan Ju LEE ; Byung Chae CHO
Journal of the Korean Ophthalmological Society 1990;31(2):176-184
The use of a secondary intraocular lens is the best method for the management of spectacle-and contact lenses-intolerant aphakic eye. Because of the high incidence and the great variety of complications associated with anterior chamber lenses, a sulcus-fixed posterior chamber lens is more desirable than an anterior chamber lens. Therefore we have performed newly developed surgical techniques using 25-gauge needle for implanting a posterior chamber lens in the eye without posterior capsular support by securing haptic of the posterior chamber lens to the sclera at the ciliary sulcus with 9~0 prolene suture. These techniques have been sucessfully performed and have produced considerable visual improvement in thirteen aphakic eyes, two patients who had dislocated lens, and two pseudophakic patients who had sun-set syndrome. Eighty-eight percent of the 17 eyes had a postoperative visual acuity of 20/30 or better. The complications in three eyes were transient hyphema, transient vitreitis and exudate in lens surface, and pupillary capture. We have not yet experienced in our series any serious complication, such as lens dislocation, cystoid macular edema, retinal detachment, 2ndary glaucoma, endophthalmitis, and corneal decompensation, but long term follow up and more experience are necessary to establish the safety.
Anterior Chamber
;
Endophthalmitis
;
Exudates and Transudates
;
Follow-Up Studies
;
Glaucoma
;
Humans
;
Hyphema
;
Incidence
;
Lens Implantation, Intraocular*
;
Lens Subluxation
;
Lenses, Intraocular*
;
Macular Edema
;
Needles
;
Polypropylenes
;
Retinal Detachment
;
Sclera
;
Sutures
;
Visual Acuity