Clinical characteristics of 336 infants referred for chromosomal study during neonatal period from Jan. 1985 to Dec. 1994 to the cytogenetic laboratory of St. Mary's Hospital, Catholic University Medical College were reviewed. Karyotypes were analysed from peripheral blood lymphocyte cultures and G-banding was carried out. A thorough survey of the clinical reasons for chromosomal analysis, prevalence of chromosomal abnormalities in each disease category, and the patterns of chromosomal aberrations were done. The results were as follows, 1) Down syndrome was the most common indication for chromosome analysis in the newborn period, consisting of 37.8 % of all cases referred. Other indications included skeletal anomaly, multi-organ anomalies, cleft lip/palate, ambiguous genitalia, odd looking face, gastrointestinal anomaly, central nervous system anomaly, and Turner syndrome. 2) Overall in 42.9 percent of cases referred, chromosomal abnormalities was found. 3) 1'he percentage of final diagnosis in suspected Down syndrome was 85.0 #96. Overall, of the non-Down syndrome cases, 16.7 96 was given a definitive diagnosis of chromosomal abnomality. In each disease category, 57.1 % of suspected Turner syndrome and 37.2 % of multi-organ anomalies had been proved having chromosomal abnormalities. The percentages of chromosomal aberrations in isolated odd looking face, ambiguous genitalia, and skeletal anomaly were relatively low, around 5 %. None of the newborns referred because of cleft lip/palate, congenital anomalies of gastrointestinal tract or central nervous system had abnormal karyotype. 4) 95.1 % of all cases diagnosed to have chromosomal abnormality had autosomal aberrations, the remainder 4.9 % had sex chromosomal aberrations. 5) Trisomy 21 was the most common numerical aberrations of autosomes, consisting of 87.5 % and trisomy 18, trisomy 13, and mosaicism was 7.1 %, 3.6 96 and 1.8 % of total. 6) 90.7 % of Down syndrome were due to trisomy 21, the rest being translocation (7.4 %) and mosaicism (1.9 %).
Abnormal Karyotype ; Central Nervous System ; Chromosome Aberrations ; Cytogenetics ; Diagnosis ; Disorders of Sex Development ; Down Syndrome ; Gastrointestinal Tract ; Humans ; Infant ; Infant, Newborn* ; Karyotype* ; Lymphocytes ; Mosaicism ; Prevalence ; Trisomy ; Turner Syndrome

No abstract available.
Knee* ; Lipoma*

No abstract available.
Ankle Fractures* ; Ankle*

No abstract available.
Acetabulum*

No abstract available.

OBJECTIVE: Angiogenesis is a critical factor in the progression of solid tumors. The mechanisms responsible for angiogenesis in cervical neoplasia, however, are not well defined. Our study was aimed to determine the expression of VEGF(Vascular Endothelial Growth Factor), its receptor(KDR), and TGF-beta1(Transforming Growth Factor-beta1) in cervical neoplasia, to determine the role of these angiogenic factors in preinvasive(dysplastic) process and the progression of cervical cancer and to investigate the progression of angiogenesis in the transition from normal cervix to invasive squamous cell carcinoma of the uterine cervix. METHODS: The cervical lesions of 76 patients were punch biopsied and paraffin embedded. Among these, 5 were normal cervix, 36 were cervical intraepithelial lesion I-III, and the other 35 were invasive squamous cell carcinomas. The tissues were immunostained with antiVEGF, antiKDR, and antiTGF-beta1 polyclonal antibody. RESULTS: The expression of VEGF, KDR, and TGF-beta1 in CIN III was stronger than those of CIN I(p<0.01). Their expression were not significantly different among the each staged cervical cancers(p>0.01). CONCLUSIONS: These observations suggest that VEGF, KDR, and TGF-beta1 are important angiogenic factors in cervical neoplasia, especially in an early event to neoplastic transformation of cervical tissues, but these angiogenic factors are not associated with the progression of cervical cancer.
Angiogenesis Inducing Agents ; Carcinoma, Squamous Cell ; Cervix Uteri ; Female ; Humans ; Paraffin ; Phosphotransferases* ; Transforming Growth Factor beta1 ; Uterine Cervical Neoplasms ; Vascular Endothelial Growth Factor A*

Pigmented villonodular synovitis (PVNS) is a relatively rare condition. The disorder almost always involves a single joint and the knee is most commonly affected. We report on three cases of localized PVNS that involved the patella fat pad and synovium. Diagnostic and therapeutic arthroscopies were performed, and typical findings of localized PVNS were found. Complete resection of the lesions were performed arthroscopically. Arthroscopy can be used as an effective diagnostic and therapeutic tool for identification and resection of intraarticular localized PVNS of the knee.
Adipose Tissue ; Arthroscopy ; Joints ; Knee* ; Patella ; Synovial Membrane ; Synovitis, Pigmented Villonodular*

PURPOSE: The purpose of this study was to correlate birth weight, skinfold thickness, gestational age, BMI and ponderal index of neonates and maternal status with cord serum leptin concentration. METHODS: Sixty newborns were enrolled in this study. Standard growth curves were used to categorize infants as appropriate(AGA), large(LGA), or small for gestational age(SGA). Gestational age, birth weight, length, skinfold thickness, and placental weight were measured. Maternal age, weight, and height were measured. Cord blood and maternal venous blood samples were collected, and serum was separated and stored at -20degrees C. Leptin was measured by radioimmunoassay. RESULTS: Mean leptin concentration in cord blood was 4.38+/-2.65ng/ml and closely related to size and adiposity at birth, but not to gestational age. Cord blood leptin level was significantly lower in SGA infants(1.64+/-0.58ng/ml) and higher in LGA infants(5.53+/-2.64ng/ml) than in AGA infants (4.99+/-2.37ng/ml)(P<0.05). Mean leptin concentration in maternal blood(13.01+/-8.28ng/ml) was significantly higher than in cord blood(P<0.001), and maternal obesity and serum leptin concentrations did not correlate with cord blood leptin concentrations. No gender differences were found in cord blood leptin. CONCLUSION: The leptin level of cord blood is highly correlated to the birth weight and the size of adipose tissue. Leptin may be responsible for the regulation of body mass of human neonates and can be used as a marker of fetal growth.
Adipose Tissue ; Adiposity ; Birth Weight* ; Fetal Blood* ; Fetal Development ; Gestational Age ; Humans ; Infant ; Infant, Newborn ; Leptin* ; Maternal Age ; Obesity ; Parturition* ; Radioimmunoassay ; Skinfold Thickness

A clinical study was made on 131 cases of urinary lithiasis among the total number of 5.017 out-patients during the 5 years from April 1961 to March 1966, and 100 urinary calculi, safely reserved during the same period in our Department, were analyzed by a chemical method. The results were as following: 1. The incidence of urinary calculi was 2.6 per cent male to female ratio being approximately 5.5:1. 2. Over half the cases of urinary calculi in the Kyungpuk district were found in the Taegu area. The seasonal incidence was common in summer. 3. The age of the patients ranged from 20 to 40 years in approximately two thirds of all cases. 4. The location of the urinary calculi was in the ureter in 46.6 per cent, kidney, bladder, and urethra in that order of frequency. 5. The most favored predirection of ureteral stone was lower third of ureter in approximately 47.5 per cent of all cases. 6. In a number of urinary calculi in each location 87.8 per cent was single, the most common size, below 0.4 cm, in its diameter, and weight, 0.5gm. below on 33 cases. 7. The clinical symptoms of upper urinary tract lithiasis showed flank pain in 92.1 per cent, hematuria 30.1 per cent, and generalized weakness 9.8 percent as well as in lower urinary tract, painful urination in 100 per cent, urinary frequency 38.1 percent and hematuria 35.9 per cent. 8. The microscopic hematuria showed in 88.5 per cent, the incidence of it was higher in lower urinary tract calculi, and pyuria was revealed in 26. 7 per cent. 9. Ureterolithotomy was performed on 29 cases among the 75 cases requiring surgical intervention. 10. The results of qualitative analysis of 100 urinary calculi showed a mixed type of calcium phosphate and calcium oxalate in 41 percent of the cases. The major component of urinary calculi was calcium phosphate-oxalate. 11. The relationship between chemical components of calculi and urinary tract shored calcium phosphate and calcium oxalate more in upper urinary tract, and calcium phosphate and calcium carbonate more in lower urinary tract.
Calcium ; Calcium Carbonate ; Calcium Oxalate ; Calculi ; Daegu ; Female ; Flank Pain ; Hematuria ; Humans ; Incidence ; Kidney ; Lithiasis ; Male ; Outpatients ; Pyuria ; Seasons ; Ureter ; Urethra ; Urinary Bladder ; Urinary Calculi ; Urinary Tract ; Urination ; Urolithiasis*

No abstract available.
Angiolipoma*