1.The analysis of the emergency patients: for the training of emergency medicine residents.
Kwang Je BAEK ; Seung Hoi PARK ; Kyung SUN ; Youn Hee CHANG ; Byung Sun UM ; Yun Sik HONG
Journal of the Korean Society of Emergency Medicine 1993;4(2):138-147
No abstract available.
Emergencies*
;
Emergency Medicine*
;
Humans
2.Recurrence of Gastric Adenocarcinoma and Its Relating Factors.
Sun Il LEE ; Byung Wook MIN ; Joon Won UM ; Seung Joo KIM ; Young Jae MOK
Journal of the Korean Cancer Association 2000;32(6):1007-1014
PURPOSE: The purpose of this study is to analyze the mode of recurrence and it's relating factors in gastric adenocarcinoma. MATERIALS AND METHODS: 1,446 patients who had been undergone gastrectomy for gastric adeno carcinoma from September 1983 to December 1996 (Department of Surgery, Korea University) were studied (median follow-up was 2.9 years). Of them, 243 patients who had been proven recurrence were studied on recurrence mode and clinicopathological factors. RESULTS: The mean duration to recurrence was 22 months. The modes of recurrence were locore gional (30.0%), peritoneal (23.0%), hematogenous (19.3%) and distant lymph node metastasis (4.1%) in order. In 23.5%, more than 2 recurrent pattern were combined. Age, gross type, tumor size and stage were statistically significant to the mode of recurrence. The disease free survival was calculated: regional lymph node, number of lymph node, stage, and tumor emboli had statistical significance in all types of recurrence and in locoregional recurrence, tumor size was significant. Multivariate analysis showed that regional lymph node influenced the disease free survival period in all cases and tumor size in locoregional recurrence. CONCLUSION: The number of positive regional lymph node and tumor size are important factors predicting the timing of recurrence after curative resection for gastric adenocarcinoma.
Adenocarcinoma*
;
Disease-Free Survival
;
Follow-Up Studies
;
Gastrectomy
;
Humans
;
Korea
;
Lymph Nodes
;
Multivariate Analysis
;
Neoplasm Metastasis
;
Recurrence*
;
Stomach Neoplasms
3.Gene Transfer Effects of Thymidine Kinase Gene of Herpes Simplex Type 1 on Ganciclovir Cytotoxicity in Gastric Cancer Cell Line.
Jae Kyung ROH ; Soo Jung GONG ; Joo Hang KIM ; Hyo Dong UM ; Nae Chun YOO ; Jin Hyuk CHOI ; Jae Jin SONG ; Sun Young RHA ; Hyun Cheol CHUNG ; Jin Sik MIN ; Byung Soo KIM
Journal of the Korean Cancer Association 1998;30(1):20-30
PURPOSE: Gastric cancer is the most common malignancy in Korea. Although treatment such as surgery, chemotherapy, and immunotherapy has greatly improved, the mortality rate of gastic cancer is still high, A new therapeutic trial is necessary to improve the cure rate of gastric cancer. Therefore we investigated the pre-clinical significance of HSV-tk gene therapy using retroviral vector for gastric cancer cell lines. MATERIALS AND METHODS: LNC/HSV-tk retroviral vector and PA317/LNC/HSV-tk producer cell line were constructed. HSV-tk gene transduction and expression were detected by PCR. An in vitro ganciclovir(GCV) sensitivity test was performed by MTT assay. To evaluate in vivo GCV sensitivity, GCV was intraperitoneally injected after tumor formation in the nude mice. Bystander effect was observed in vitro MTT assay using YCC- S-2 cell line and in vivo using N87 and YCC-S-2 cell lines. RESULTS: The in vitro GCV sensitivity test showed that the growth inhibition was 30~32% with 0.5 uM GCV and 52~77% with 500 uM GCV in the HSV-tk transduced cell line in comparison with 0- 5% with 0.5 and 500 uM GCV in the parent cell line. The in vivo GCV administration showed that the tumors induced by HSV-tk transduced N87 cell line and YCC-S-2 cell line decreased completely, while the tumors with the parent cell lines continued to grow in nude mice. We observed no tumor cells in tissue specimen of the tumor induced by the N87/HSV-tk cell line after. GCV administration. In vitro and in vivo bystander effects were observed in HSV-tk/GCV system due to the resultant cell death exceeding the proportion of HSV-tk transduced cells in the mixtures of HSV-tk transduced and parent cells. CONCLUSION: HSV-tk transduced gastric cancer cell lines showed sensitivity to GCV and a bystander effect was observed. These results suggested that HSV-tk/GCV system should be evaluated in the clinical settings.
Animals
;
Bystander Effect
;
Cell Death
;
Cell Line*
;
Drug Therapy
;
Ganciclovir*
;
Genetic Therapy
;
Herpes Simplex*
;
Humans
;
Immunotherapy
;
Korea
;
Mice
;
Mice, Nude
;
Mortality
;
Parents
;
Polymerase Chain Reaction
;
Stomach Neoplasms*
;
Thymidine Kinase*
;
Thymidine*
;
Zidovudine
4.Granular Cell Tumors of the Abdominal Wall.
Jung Suk AN ; Sun Hee HAN ; Sung Bae HWANG ; Ju Han LEE ; Byung Wook MIN ; Jun Won UM ; Eung Seok LEE ; Heum Rye PARK ; Young Sik KIM
Yonsei Medical Journal 2007;48(4):727-730
Granular cell tumors (GCT) are found in virtually any body site, including the tongue, skin, subcutaneous tissue, breast, rectum and vulva. However, they are rarely seen in the abdominal wall. We report here on a rare case of GCT in the rectus muscle of the abdominal wall. A 44-year-old woman presented with a non-tender, hard mass in the right lower abdominal wall. Upon microscopic examination, the tumor was found to comprise of large polygonal cells with an abundant eosinophilic granular cytoplasm and round to oval nuclei. Upon immunohistochemical staining, the large cells showed S-100 and CD68 positive granular aggregates in the cytoplasm. Many lysosomes of variable size were observed in the cytoplasm.
Abdominal Neoplasms/metabolism/*pathology
;
Adult
;
Female
;
Granular Cell Tumor/metabolism/*pathology
;
Humans
;
Immunohistochemistry
;
Rectus Abdominis/metabolism/*pathology
;
S100 Proteins/metabolism
5.Granular Cell Tumors of the Abdominal Wall.
Jung Suk AN ; Sun Hee HAN ; Sung Bae HWANG ; Ju Han LEE ; Byung Wook MIN ; Jun Won UM ; Eung Seok LEE ; Heum Rye PARK ; Young Sik KIM
Yonsei Medical Journal 2007;48(4):727-730
Granular cell tumors (GCT) are found in virtually any body site, including the tongue, skin, subcutaneous tissue, breast, rectum and vulva. However, they are rarely seen in the abdominal wall. We report here on a rare case of GCT in the rectus muscle of the abdominal wall. A 44-year-old woman presented with a non-tender, hard mass in the right lower abdominal wall. Upon microscopic examination, the tumor was found to comprise of large polygonal cells with an abundant eosinophilic granular cytoplasm and round to oval nuclei. Upon immunohistochemical staining, the large cells showed S-100 and CD68 positive granular aggregates in the cytoplasm. Many lysosomes of variable size were observed in the cytoplasm.
Abdominal Neoplasms/metabolism/*pathology
;
Adult
;
Female
;
Granular Cell Tumor/metabolism/*pathology
;
Humans
;
Immunohistochemistry
;
Rectus Abdominis/metabolism/*pathology
;
S100 Proteins/metabolism
6.Association of DNA-dependent protein kinase with hypoxia induciblefactor-1 and its implication inresistance to anticancer drugs in hypoxic tum or cells.
Jee Hyun UM ; Chi Dug KANG ; Jae Ho BAE ; Gin Gu SHIN ; Do Won KIM ; Dong Wan KIM ; Byung Seon CHUNG ; Sun Hee KIM
Experimental & Molecular Medicine 2004;36(3):233-242
Tumor hypoxia contributes to the progression of a malignant phenotype and resistance to ionizing radiation and anticancer drug therapy. Many of these effects in hypoxic tumor cells are mediated by expression of specific set of genes whose relation to therapy resistance is poorly understood. In this study, we revealed that DNA-dependent protein kinase (DNA-PK), which plays a crucial role in DNA double strand break repair, would be involved in regulation of hypoxia inducible factor-1 (HIF-1). HIF-1beta-deficient cells showed constitutively reduced expression and DNA-binding activity of Ku, the regulatory subunit of DNA-PK. Under hypoxic condition, the expression and activity of DNA- PK were markedly induced with a concurrent increase in HIF-1alpha expression. Our result also demonstrated that DNA-PK could directly interact with HIF- and especially DNA-PKcs, the catalytic subunit of DNA-PK, could be involved in phosphorylation of HIF-1alpha, suggesting the possibility that the enhanced expression of DNA- PK under hypoxic condition might attribute to modulate HIF-1alpha stabilization. Thus, the correlated regulation of DNA-PK with HIF-1 could contribute to therapy resistance in hypoxic tumor cells, and it provides new evidence for developing therapeutic strategies enhancing the efficacy of cancer therapy in hypoxic tumor cells.
Antibodies/immunology
;
Cell Hypoxia
;
Cell Line, Tumor
;
DNA Helicases/immunology/metabolism
;
DNA-Binding Proteins/genetics/*metabolism/*physiology
;
Deferoxamine/pharmacology
;
Drug Resistance, Neoplasm/*physiology
;
Humans
;
Immunoprecipitation
;
Neoplasms/enzymology/*metabolism
;
Nuclear Proteins/genetics/*metabolism/physiology
;
Phosphorylation
;
Protein-Serine-Threonine Kinases/metabolism/*physiology
;
Research Support, Non-U.S. Gov't
;
Transcription Factors/genetics/*metabolism/physiology
;
Up-Regulation
7.Korean physicians' policies for postoperative surveillance of colorectal cancer.
Sun Kyung BAEK ; Sang Cheol LEE ; Jong Gwang KIM ; Jun Won UM ; Suk Hwan LEE ; Byung Ik JANG ; Jae Jun PARK ; Tae Won KIM
The Korean Journal of Internal Medicine 2018;33(4):783-789
BACKGROUND/AIMS: We explored Korean physicians’ policies for surveillance of colorectal cancer (CRC) after curative surgery. METHODS: Web-based self-report questionnaires were developed. Invitations to participate were emailed to physicians who diagnosed and treated CRC from October 1 to November 15, 2015. The questionnaire consisted of the role doctors played in the surveillance, examination of surveillance, and duration of postoperative surveillance according to CRC stage or primary site of the cancer. RESULTS: Ninety-one physicians participated in the online survey, and 78 completed the survey. Sixty-seven participants (13%) answered “up to 5 years” for stage I surveillance duration; and 11 (13%) responded with a duration of > 5 years for stage I. A total of 61 (75%) responded with a surveillance duration of up to 5 years for stage II; and 19 (24%) responded with a duration of > 5 years for stage II. Sixty-seven (97%) and 61 (91%) physicians monitored patients with stage II/III every 3 or 6 months by laboratory examination and by abdominopelvic computed tomography scan for the first year, respectively. A total of 43 (53%) responded with a surveillance duration of up to 5 years for stage IV; and 46 (46%) responded with a duration of > 5 years for stage IV after curative resection. CONCLUSIONS: Korean physicians mostly followed up CRC using intensive postoperative surveillance. In preference to monitoring over a comparatively shorter period of time, the physicians tended to prefer monitoring patients post-operatively over a > 5 year period, particularly in cases of advanced-stage CRC.
Colorectal Neoplasms*
;
Electronic Mail
;
Follow-Up Studies
;
Humans
;
Surveys and Questionnaires
8.A Case of Multiple Lymphomatous Polyposis Developed after Complete Remission of Diffuse Large B-cell Type Nasopharyngeal Lymphoma.
Dong Kyu PARK ; Yoon Tae JEEN ; Hoon Jai CHUN ; Byung Won HUR ; Yeon Seok SEO ; Chang Don KANG ; Jung Whan LEE ; Chi Wook SONG ; Soon Ho UM ; Chang Duck KIM ; Ho Sang RYU ; Jin Hai HYUN ; In Sun KIM
Korean Journal of Gastrointestinal Endoscopy 2000;21(2):642-648
Multiple lymphomatous polyposis (MLP) is a term used to describe malignant lymphoma of the gastrointestinal tract that manifest as polyposis. MLP is believed to represent gastrointestinal involvement by mantle cell lymphoma (MCL), primarily based on its histologic and immunophenotypic similarities with MCL. We have experienced a case of MCL presented as a peculiar feature of multiple lymphomatous polyposis in a 49-year old male patient. He had been diagnosed diffuse large B cell lymphoma of nasopharynx and treated by radiation therapy and CHOP chemotherapy. He newly developed MCL after 10 years in complete remission of diffuse large B cell lymphoma. After newly developed lymphoma was compared with former diagnosed lymphoma, we concluded that they were not same type each other. We reviewed a total of 13 patients including this case, of MLP, which were reported in various Korean literature, and literatures are reviewed.
B-Lymphocytes*
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Drug Therapy
;
Gastrointestinal Tract
;
Humans
;
Lymphoma*
;
Lymphoma, B-Cell
;
Lymphoma, Mantle-Cell
;
Male
;
Middle Aged
;
Nasopharynx
9.Two Cases of Cronkhite - Canada Syndrome with Remission.
Hyo Jung KIM ; Yoon Tae JEEN ; Hoon Jai CHUN ; Byung Won HUR ; Young Sun KIM ; Jae Hong PARK ; Hwang Rae CHUN ; Chang Don KANG ; Jung Whan LEE ; Chi Wook SONG ; Soon Ho UM ; Chang Duck KIM ; Ho Sang RYU ; Jin Hai HYUN
Korean Journal of Gastrointestinal Endoscopy 2000;21(1):543-548
The Cronkhite-Canada Syndrome (CCS) is a monfamilial disorder of adults characterized by diffuse gastro-intestinal polyposis, ectodermal changes consisting of alopecia, dystrophy of nails and cutaneous hyper-pigmentation. The pathogenesis and the causes of CCS remain unknwon but the symptoms such as diarrhea and malnutrition are generally progressive, and the prognosis is knwon to be poor. Though the definitive treatment is not well known, it has been reported that the conservative management is the most important treatment, and that the clinical sourse can be reversible. One case was experienced involving Cronkhite-Canada Syndromen in a patient who was managed by conservative treatment and an other who was treated by corticosteroid. These two cases are reported herein with a review of corresponding literature.
Adult
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Alopecia
;
Canada*
;
Diarrhea
;
Ectoderm
;
Humans
;
Intestinal Polyposis
;
Malnutrition
;
Prognosis
10.Recurrence and Survival Analysis in Skin-Sparing Mastectomy with Immediate Reconstruction Compared with Conventional Mastectomy.
Eun Hwa PARK ; Ji Hun KIM ; Byung Ho SON ; Beom Seok KWAK ; Jung Kyung KIM ; Hee Jung KIM ; Jung Sun LEE ; Soo Jung HONG ; Taek Jong LEE ; Jin Sup UM ; Sei Hyun AHN
Journal of Breast Cancer 2005;8(4):178-185
PURPOSE: A skin-sparing mastectomy (SSM), followed by immediate reconstruction, which has aesthetic advantages, is being increasingly used to treat many early breast carcinomas; however, there are few data regarding the outcome and safety of this procedure. The objective of this study was to evaluate the safety of utilizing a SSM with immediate reconstruction compared with the outcome of a conventional mastectomy. METHODS: A retrospective review was performed on 169 patients who underwent a SSM with immediate reconstruction, and 2102 patients who received a conventional mastectomy between January 1996 and December 2002, at the Asan Medical Center. The patient and tumor characteristics, as well as the types of reconstruction, incidences of recurrence and survival rates were examined. RESULTS: The mean age of the SSM group was younger (39 vs. 47 years, p < 0.001), and the mean tumor size smaller than those of the mastectomy group (2.6 vs. 3.2cm, p = 0.002). Lymph node involvement was present in 39.6% and 48.4% of the SSM and mastectomy groups, respectively (p = 0.24). The proportion at early stages (0 and 1) in the SSM group was higher than those in the mastectomy group (50.9 vs. 30.7%, p < 0.001). In the high-risk patients, postoperative radiation was administered to 24.1 and 54.9% of the SSM and mastectomy group, respectively (p = 0.002). With a median follow-up of 41 months, the recurrence rates for the SSM and mastectomy groups were 11.8 (20 of 169 patients) and 14.4% (303 of 2102 patients), respectively (p = 0.22). There were no differences in the locoregional and distant recurrences between the two groups. The 5-year disease free survivals for the SSM and mastectomy groups were 81.9 and 81.7%, respectively (p = 0.71). The 5-year overall survivals for the SSM and mastectomy groups were 91.7 and 88,8%, respectively (p = 0.13). In a univariate analysis, the factors associated with a recurrence and the survival rates were the tumor stage and a lymph node positive state. CONCLUSION: No significant differences were found in the recurrence and survival rates of the SSM group, with immediate reconstruction, compared to those of the mastectomy only group. A skin-sparing mastectomy, with immediate reconstruction, which has greater aesthetic benefits, appeared to be an oncologically safe treatment option for breast carcinomas.
Breast Neoplasms
;
Chungcheongnam-do
;
Follow-Up Studies
;
Humans
;
Incidence
;
Lymph Nodes
;
Mastectomy*
;
Recurrence*
;
Retrospective Studies
;
Survival Analysis*
;
Survival Rate