1.Primitive Neuroectodermal Tumor of the Ovary: A case report .
Chan Kwon JUNG ; Eun Sun JUNG ; Youn Soo LEE ; Byung Kee KIM ; Sun Moo KIM
Korean Journal of Pathology 1999;33(8):631-635
Primitive neuroectodermal tumors (PNET) of the ovary are rare tumors with an exclusive or almost exclusive malignant neuroectodermal composition, and are generally regarded as a monodermal expression of an ovarian teratoma. The tumors are basically identical with the lesions of the same name occuring typically in the central nervous system of children. These tumors consist chiefly of undifferentiated small cells resembling neuroblasts. There are also mature, well- differentiated neuroectodermal cells, such as astrocytes and ependymal cells. We report a case of ovarian PNET with glial and neuroblastic differentiation and focal teratomatous foci of non-neural tissue in a 17-year-old female.
Adolescent
;
Astrocytes
;
Central Nervous System
;
Child
;
Female
;
Humans
;
Neural Plate
;
Neuroectodermal Tumors, Primitive*
;
Ovary*
;
Teratoma
2.Hemimegalencephaly: A case report.
Youn Soo LEE ; Eun Sun JUNG ; Sun Moo KIM ; Byung Kee KIM
Korean Journal of Pathology 2000;34(3):243-247
Hemimegalencephaly is an uncommon sporadic congenital malformation of the central nervous system characterized by enlargement of one cerebral hemisphere with cranial asymmetry, hemiparesis, epilepsy, and mental retardation. This report deals with a 12-month-old girl with intractable seizure and developmental delay, who revealed hemispheric asymmetry and enlarged right cerebral hemisphere. MRI scan revealed asymmetric enlargement of right cerebral hemisphere with lissencephaly and multifocal calcification. She underwent right frontal lobectomy and parietal cortical resection, but died of complication of surgery. Histological features included loss of cortical lamination, large atypical neurons, neuronal heterotopia, and astrocytosis with dystrophic calcification. The heterotopic neurons in the white matter were suggestive of aberrant neuronal migration.
Central Nervous System
;
Cerebrum
;
Epilepsy
;
Female
;
Gliosis
;
Humans
;
Infant
;
Intellectual Disability
;
Lissencephaly
;
Magnetic Resonance Imaging
;
Malformations of Cortical Development*
;
Neurons
;
Paresis
;
Rabeprazole
;
Seizures
3.Malignant Melanoma of the Anus: Report of a case.
Eun Sun JUNG ; Byung Kee KIM ; Sun Moo KIM ; Sang In SHIM
Korean Journal of Pathology 1996;30(3):276-278
This report describes a primary malignant melanoma which developed in the anus, as documented by light microscopy and immunohistochemistry. A 53-year-old woman had a 4 month history of a protruding mass in the anal canal. The mass was located in the squamo-columnar junction of the anal canal, measuring 5.0x4.5 cm. Its cut surface was dark brown and poorly circumscribed. The histologic appearance was characterized by epithelioid or spindle cells with prominant nucleoli and frequent atypical mitosis. Melanin pigments were strongly seen in Fontana-Masson stain. Immunoreactivity revealed that the cytoplasm of tumor cells was strongly positive with antibody directed against S-100 protein, vimentin and it was focally positive with neuron specific enolase.
Female
;
Humans
4.Detection of ras gene mutations in human cancer by PCR-SSCP.
Chul Min KIM ; Joo In PARK ; Chi Duk KANG ; Sun Hee KIM ; Young Hong PARK ; Soo Ja JUNG ; Byung Sun JUNG
Journal of the Korean Cancer Association 1993;25(3):429-444
No abstract available.
Genes, ras*
;
Humans*
5.Clinical significance and incidence of antineutrophil cytoplasmic antibody.
Jung OH ; Yeong Jin CHOI ; Seok Jin KANG ; Byung Kee KIM ; Sang In SHIM ; Sun Moo KIM
Korean Journal of Clinical Pathology 1993;13(2):295-302
No abstract available.
Antibodies, Antineutrophil Cytoplasmic*
;
Incidence*
6.Occult Hepatocellular Carcinoma Metastasized to Heart: A case report.
Nam Jin YOO ; Jung Yong LEE ; Seok Jin GANG ; Byung Kee KIM ; Sun Moo KIM
Korean Journal of Pathology 1986;20(3):359-361
We have experienced a case of occult hepatocellular carcinoma metastasized to the heart in a 41 year old female. The hepatocellular carcinoma invaded the hepatic vein, grew in a snakelike fashion up the inferior vena cava and reached the right atrium. Ultrastural examination in this case confirmed the hepatocellular origin of the tumor.
Female
;
Humans
;
Carcinoma, Hepatocellular
7.Clinical study of hysterosalpingography in infertile women.
Jung Ok REW ; Byung Sun KIM ; Dong Keun KIM ; Hye Ryun OH ; Chan Moo PARK
Korean Journal of Obstetrics and Gynecology 1992;35(11):1621-1629
No abstract available.
Female
;
Humans
;
Hysterosalpingography*
8.Expression of Matrix Metalloproteinase-1,2,3 and Type IV Collagen in Gastric Adenocarcinoma: Influence on Lymph Node Metastasis and Prognosis.
Eun Sun JUNG ; Byung Gee KIM ; Jo Hyun PARK ; Sang In SHIM
Korean Journal of Pathology 1999;33(4):251-258
Matrix metalloproteinases are believed to play an important role in tumor invasion and metastasis. But little is known about the role of them in the gastric adenocarcinoma. We investigated the expression of matrix metalloproteinase-1,2,3 in eighty paraffin blocks of the primary gastric adenocarcinoma tissues with immunohistochemistry and analysed their correlation with lymph node metastasis and survival. MMP-1,2,3 were expressed most intensely in the fibroblasts around the tumor stroma. In our study the increased immunoreactivity of MMP-2 only showed statistically significant correlation with lymph node metastasis (P=0.0517, Odd's ratio=2.274). But MMP-1,2,3 all were correlated with survival. Type IV collagen was observed in the vascular basement membranes and tumor basement membranes and showed statistically significant correlation with lymph node metastasis (P=0.0002, Odd's ratio=0.194) and prognosis (P=0.0001). The immunoreactivity of MMP-2 and type IV collagen was inversely correlated (Kendall's Tau-b correlation = 0.37482, P=0.0001). Our results suggest that in human gastric adenocarcinoma the increased immunoreactivity of MMP-2 and the decreased immunoreactivity of type IV collagen has an important role in lymph node metastasis and prognosis. MMP-1,3 are not correlated with lymph node metastasis but correlated with survival. The mechanism responsible for the production of MMP by the host fibroblasts remains obscure and requires further investigation.
Adenocarcinoma*
;
Basement Membrane
;
Collagen Type IV*
;
Fibroblasts
;
Humans
;
Immunohistochemistry
;
Lymph Nodes*
;
Matrix Metalloproteinases
;
Neoplasm Metastasis*
;
Paraffin
;
Prognosis*
9.The clinical value of the ultrasonography in the diagnosis of the malignant ovarian ca.
Kwang Hwi PARK ; Sun Kyung LEE ; Byung Hee SUH ; Jae Hyun LEE ; Jung Eun MOK
Korean Journal of Obstetrics and Gynecology 1993;36(4):543-552
No abstract available.
Diagnosis*
;
Ultrasonography*
10.The clinical value of the ultrasonography in the diagnosis of the malignant ovarian ca.
Kwang Hwi PARK ; Sun Kyung LEE ; Byung Hee SUH ; Jae Hyun LEE ; Jung Eun MOK
Korean Journal of Obstetrics and Gynecology 1993;36(4):543-552
No abstract available.
Diagnosis*
;
Ultrasonography*