The patient is a 20 years old female, Korean, who has many freckles and dark brownish pigment over the face, neck and hands. She also has a rice sized wart like elevation on lower lid margin and pea-nut sized elevation on nose bridge. Histopathologically the former was basal cell carcinoma and the latter squamous cell carcinoma.
Carcinoma, Basal Cell ; Carcinoma, Squamous Cell ; Female ; Hand ; Humans ; Ichthyosis* ; Melanosis ; Neck ; Nose ; Warts ; Xeroderma Pigmentosum* ; Young Adult

Although spontaneous bacterial peritonitis is a frequent complication in the childhood nephrotic syndrome, it is very rare in adults with nephrotic syndrome. It frequently develops when the patients are either in relapse or receiving steroid therapy at the time peritonitis is diagnosed. We report an unusual case of a spontaneous bacterial peritonitis as the presenting feature in a 15-year-old male patient with nephrotic syndrome. He presented with diffuse abdominal pain and distension for 15 days. Abdominal paracentesis revealed the diagnostic laboratory findings of peritonitis, and the bacterial culture of the ascites showed a mixed growth of Escherichia coli and Pseudomonas aeruzinosa. His serum albu- min level was 1.6gldL and the amount of 24 hours proteinuria was 21.0g/day. Although he was treated with adequate antibiotics for 3 weeks, the peritonitis was more aggravated. We decided to insert a catheter into the peritoneal cavity for continuous drainage of the intractable ascites. Two weeks after drainage, the peritonitis improved as the peritonitis subsided, the proteinuria disappeared completely without a steroid therapy. Six months after spontaneous remission, the proteinuria have recurred, and the kidney biopsy then showed focal segmental glomerulorsclerosis.
Abdominal Pain ; Adolescent ; Adult ; Anti-Bacterial Agents ; Ascites ; Biopsy ; Catheters ; Drainage ; Escherichia coli ; Humans ; Kidney ; Male ; Nephrotic Syndrome* ; Paracentesis ; Peritoneal Cavity ; Peritonitis* ; Proteinuria ; Pseudomonas ; Recurrence ; Remission, Spontaneous

PURPOSE: To analysis the results of iliac artery angioplasty with stent placement for the treatment of the chronic lower limb ischemic patients. METHODS: One hundred-six stenotic lesions of the iliac artery (87 male, 4 female, age 42~86) were treated with balloon angioplasty and stent placement from February 1995 through March 1999. All patients were symptomatic including claudication, resting pain and tissue loss. Indications for iliac artery stent placement were long segment stenotic lesion (>3 cm), dissection, failed balloon angioplasty. The pre-stenting and post-stenting clinical records, arteriograms, segmental limb pressure measurements (ankle-brachial and thigh-brachial indexes), and duplex scan were reviewed. The patients were follow up at 1, 3 and 6 month after stent placement and every 6 months thereafter. The Kaplan-Meier survival curve was used to calculate the cumulative patency rates. RESULTS: Patients were followed for up to 45 months (mean 16 months). The technical success rate was 104/106 (98%). The ankle-brachial index or thigh-brachial index improved from 0.64 in pre-stenting to 0.87 in post-stenting. The intraluminal pressure gradient decreased from 21.4 mmHg in pre-stenting to 2.5 mmHg in post-stenting. There was no major complication without 2 immediate stent occlusion. Cumulative primary patencies were 92%, 82%, 74% and 74% at 6, 12, 24 and 36 months. CONCLUSION: Excellent clinical results were achieved for the iliac artery stent placement for the chronic lower limb ischemic patients. Iliac stenting showed low morbidity and mortality rate, and was safe and effective for the treatment of iliac artery occlusive disease.
Angioplasty* ; Angioplasty, Balloon ; Ankle Brachial Index ; Extremities ; Female ; Follow-Up Studies ; Humans ; Iliac Artery* ; Ischemia* ; Lower Extremity* ; Male ; Mortality ; Stents*

The best treatment modality of spontaneous intracerebral hematoma is still controversial. But stereotactic surgery can minimize the brain damage and be performed under local anesthesia. Recently we experienced 46 cases of spontaneous intracerebral hematoma which were operated using ZD(Zamorano-Dujovny) stereotactic system and urokinase irrigation from November 1990 to April 1993. Before operation, computerized tomographic scanning was done to locate the hematoma, assess the amount, and to determine the stereotactic coordinates. The silastic tube was inserted after stereotactic evacuation of hematoma and urokinase irrigation was repeated every 6 to 8 hours until the hematoma was cleared up. The results were analysed and we concluded that we can substitute open craniectomy or conservative treatment for stereotactic evacuation of spontaneous intracerebral hematoma combined with urokinase irrigation in certain instances and can minimize the brain damage regardless the patient's general condition or past history.
Anesthesia, Local ; Brain ; Cerebral Hemorrhage* ; Hematoma ; Urokinase-Type Plasminogen Activator*

Radiation therapy is one of the cardial therapeutic modality on breast cancer. Three decades ago, the heart was considered to be radioresistant, but now it is generally recognized that the heart is also radiosensitive. The most common clinical syndromes after irradiation are pericarditis in acute and chronic forms, cardiomyopathy, valvular disease and, to a lesser degree, complete atrioventricular block. However, lesions of coronary vessels had been considered exceptionally rare and even questionable. And then there have been a few case reports for acute myocardial infartion after irradiation for left sided breast cancer and it may be considered that radiation therpy can injure endothelium of coronary artery and cause ischemic coronary artery disease. We report the case of a 38 years old women who developed acute anterior wall myocardial infarction after irradiation for left sided breast cancer.
Adult ; Anterior Wall Myocardial Infarction ; Atrioventricular Block ; Breast Neoplasms* ; Breast* ; Cardiomyopathies ; Coronary Artery Disease ; Coronary Vessels ; Endothelium ; Female ; Heart ; Humans ; Myocardial Infarction* ; Pericarditis

Congenital vascular malformations (CVM) have many different clinical presentations, ranging from an asymptomatic birthmark to a life-threatening status. There has been confusion in the classification of these malformations. Two major classification systems are used at the present time: one is the Mulliken and coworkers' system that has been adopted by the International Society for the Study of Vascular Anomalies, and the other is the Hamburg classification that was declared in the 7th Meeting of the International Workshop on Vascular Malformations in Hamburg 1988. The latter is used in this article. BACKGROUND: There are many difficulties in the surgical extirpation of CVM because of their invasiveness, variability, hypervascularity, and evolutibility, especially in a diffuse infiltrating type of CVM. Thus, many endovascular ablative agents have been utilized since 1930s, but there were some handicaps, such as recanalization of previously treated vessels. Since the 1980s, Yakes has reported on much research about the effectiveness of absolute alcohol (98% ethyl alcohol) which incurs permanent vessel wall destruction. AIMS: We performed this study to evaluate the effectiveness of pure ethanol (95-99% ethyl alcohol, Samsung Medical Center, Seoul, Korea) in the treatment of inoperable CVM, to identify the complications that occur and to establish the method of endovascular ablative therapy. MATERIALS AND METHODS: From August 1996 through October 1997, we applied 37 sessions of sclerotherapy using direct puncture technique with pure ethanol to 19 patients with the extratruncular, diffuse infiltrating type of CVM (11 predominantly venous, 8 predominantly arteriovenous shunting)among 250 CVM patients registered at the CVM Clinic of Vascular Center at Samsung Medical Center. RESULTS: Angiographically, the results were excellent in 33 (89%) and good in 3 (9%) sessions. Only one (3%) session failed due to extravasation of the contrast media. The mean follow-up period was only 6 months; 17 (89%) patients were symptomatically improved. Some complications, such as ischemic bullae, deep vein thrombosis, and hematuria, developed, but those patients were recovered without any problem. CONCLUSIONS: The short-term results of pure ethanol sclerotherapy for the diffuse infiltrating type of CVM were good. With more clinical experience, this new treatment modality will be more effective. Further investigations are needed to solve the some complications.
Classification ; Contrast Media ; Education ; Ethanol* ; Follow-Up Studies ; Hematuria ; Humans ; Punctures ; Sclerotherapy* ; Seoul ; Vascular Malformations* ; Venous Thrombosis

Situs inversus is a rare condition with genetic predisposition and is characterized by transposition of both heart and intra-abdominal viscera to the opposite side of the body. Cholangiocarcinoma in this condition has rarely been reported. We present a case of adenocarcinoma of the common hepatic duct proximal to the cystic duct in a 68-year-old male with total situs inversus. The patient presented with complaints of abdominal pain, intermittent fever and chilling sensation without jaundice. Magnetic resonance cholangiopancreatography prior to surgery demonstrated segmental narrowing of the common hepatic duct proximal to the cystic duct and two stones in the proximal portion of the narrowed segment. Open laparotomy was performed to remove the lesion. Cholangiocarcinoma was confirmed pathologically. Magnetic resonance cholangiopancreatography was the only pre-operative diagnostic method which had suggested malignancy in this case.
Abdominal Pain ; Adenocarcinoma ; Aged ; Cholangiocarcinoma* ; Cholangiopancreatography, Magnetic Resonance* ; Cystic Duct ; Diagnosis* ; Fever ; Genetic Predisposition to Disease ; Heart ; Hepatic Duct, Common ; Humans ; Jaundice ; Laparotomy ; Male ; Sensation ; Situs Inversus* ; Viscera

OBJECTIVE: Hepatic dysfunction frequently occurs in patients with hematologic malignancies and aplastic anemia who receive intensive chemotherapy or bone marrow transplantation (BMT). The role of laparoscopic liver biopsy in patients with hematologic disorders is very important to determine the etiological factors and to make treatment decisions. The aim of the present study was to evaluate the possible causes of liver disease in patients with abnormal liver function tests. METHODS: Laparoscopy guided liver biopsy was performed in 38 subjects who were receiving intensive cytotoxic therapy with BMT or without BMT. Two to three pieces of liver tissues were obtained in each patients using Vim-Silverman needle with electrocoagulation on biopsy site. Platelet transfusions were given if platelet count was less than 50,000/mm3. 39 biopsies were obtained in 38 patients. RESULTS: At the time of liver biopsy, platelet count was 170,000+/-138000/mm3 (range: 42,000 - 798,000/mm3). No procedure-related complications were observed. Biopsy findings after BMT (n=16) revealed graft versus host disease (GVHD) (n=9), drug induced hepatitis (n=6), veno-occlusive disease (n=2), viral hepatitis (n=1), and nonspecific reactive hepatitis (n=1). 3 patients of GVHD associated with other liver diseases such as drug-induced hepatitis, veno-occlusive disease and chronic active hepatitis B. The authors compared histologic diagnosis with laparoscopic findings. Laparoscopic findings of the liver surface were classified by Shimada's code number system. 5 patients who were biopsed before BMT showed cholestasis and fatty changes and it was possible to be treated with allogenic BMT. Histologic diagnosis in patients without BMT (n=18) showed viral hepatitis (n=6), drug induced hepatitis (n=5), non-specific reactive hepatitis (n=1), and others (n=6). In 12 cases (31%) laparoscopic liver biopsy led to a change in medical management. CONCLUSION: Laparascopic liver biopsy has been proven to be an effective means of assessing the cause of liver dysfunction in patients with hematologic disorders. The diagnosis obtained at laparoscopic liver biopsy could be changed the therapeutic plan in 12 of 39 (31%) patients.
Anemia, Aplastic ; Biopsy* ; Bone Marrow Transplantation ; Cholestasis ; Diagnosis ; Drug Therapy ; Drug-Induced Liver Injury ; Electrocoagulation ; Graft vs Host Disease ; Hematologic Neoplasms ; Hepatitis ; Hepatitis, Chronic ; Humans ; Laparoscopy ; Liver Diseases ; Liver Function Tests ; Liver* ; Needles ; Platelet Count ; Platelet Transfusion

The most common type of food-related foreign body in esophagus is impacted meat bolus and sudden esophageal obstruction after eating poorly chewed meat has been called the "steakhouse syndrome". It is frequently caused by underlying esophageal stenosis including abnormal ring, the sequalae of reflux esophagitis, malignancy and rarely esophageal motility disorders. A 55-year-old male patient was admitted to our hospital complaining swallowing difficulty after ingestion of a lump of chicken 3 days ago. Impacted meat bolus was found at distal esophagus on emergency endoscopy. However, there was no definite anatomical stenotic lesion after removal of meat with the polypectomy snare. Esophageal manometry showed segmental, high amplitude of esophageal pressure at lower esophagus with normal peristalsis and occasional triple peaked waves. The manometry finding was consistent with nutcracker esophagus. We report a case of steakhouse syndrome associated by nutcracker esophagus without abnormality on endoscopy and esophagography.
Chickens ; Deglutition ; Eating ; Emergencies ; Endoscopy ; Esophageal Motility Disorders* ; Esophageal Stenosis ; Esophagitis, Peptic ; Esophagus ; Foreign Bodies ; Humans ; Male ; Manometry ; Meat ; Middle Aged ; Peristalsis ; SNARE Proteins

BACKGROUND: Since the 1980s, early ambulation and cardiac rehabilitation have been emphasized in clincal practice after myocardial infarction. This is based on the belief that cardiac rehabilitation can reduce cardiovascular mortality, improve functional capacity and reduce the risk of further coronary events. In this study, we investigate the effect of aerobic exercise-based cardiac rehabilitation on functiona capacity and cardiopulmonary response in patiets with myocardial infarction. METHODS: 19 patients were divided into two group(9 patients for training group and 10 patients for control group) at 4-6 weeks after acute myocardial infarction. Training group performed aerobic exercise for 8 weeks(3 sessions per week, mean 53mins per session) at 40-60% of heart rate(HR) reserve, while control group did not. Before and after 8 weeks, all patients performed symptom-limited exercise test using modified Bruce protocol. Also, breath by breath respiratory gas analysis was carried out throughout exercise test. RESULTS: For body composition, body weight(-2.7%, p<0.001), body mass index(-2.5%, p<0.001) and %body fat(-2.6%, p<0.05) were decrease significantly in training group after 8 week cardiac rehabilitation. Resting HR(-13%, p<0.05) was reduced significantly in training group, but no significant change occured in resting blood pressure between the two groups. Maximal oxygen uptake(18%, p<0.01) and anaerobic threshold(21%, p<0.05) were increased significantly in training group after 8 week cardiac rehabilitation as compared with the control group. There was no significant change in maximal O(2)pulse between the two groups. Submaximal rate-pressure product(-17%, p<0.05) and submaximal rate of perceived exertion (-2.6, p<0.001) were decreased significantly in training group after 8 week cardiac rehabilitation as compared with the control group. CONCLUSIONS: Our findings indicate that cardiac rehabilitation results in the significant improvement of functional capacity and cardiopulmonary response in patients with myocardial infarction. Cardiac rehabilitation for patients with myocardial infarction can contribute early return and readaptation to normal life, because myocardial oxygen consumption(or rate-pressure product) is decreased at the same exercise level after exercise training.
Blood Pressure ; Body Composition ; Early Ambulation ; Exercise ; Exercise Test ; Heart ; Humans ; Mortality ; Myocardial Infarction* ; Oxygen ; Rehabilitation*