1.Treatment of Pemphigus.
Byung Soon PARK ; Jin Ho CHUNG
Korean Journal of Dermatology 1997;35(3):465-474
BACKGROUND: Pemphigus is a rare, chronic blistering disease of the skin and mucous membranes with severe morbidity and occasional mortality. The clinical data of Korean pemphigus patients are quite limited, and an appropriate treatrnent regimen is not yet established. OBJECTIVE: Our purpose was to analyze the clinical characteristics of, and establish an appropriate treatment regimen for Korean pemphigus patients. METHODS: A retrospective analysis was conducted for 24 pemphigus patients seen between 1992 and 1996. RESULTS: Pemphigus vulgaris(PV) was the most common type with 17 cases, followed by seven cases of pemphigus foliaceus(PF). There were no sexual preferences, and the average age at onset for PV and PF was 46 and 50 years old, respectively. Mucosal involvement was noted in 14 cases(82%) of PV and only in one case(14/o) of PF. There was no correlation between the extent of involvement and the titer of anti ICS(intercellular substance) antibody. Most patients received prednisolone of lmg/kg, and 12 PV patients also received immunosuppressive agents. Systemic side effects were noted in 10 cases of PV, and seven PF cases did not manifest any systemic side effects. CONCLUSIONS: The clinical manifestations and results of imrnunofluorescent studies of 24 Korean pemphigus patients were similar to those of the previous studies. For treatment of pemphigus, the lowest possible doses(less than 1mg/kg) of corticosteroid in combination with immunosuppressive agents appears to be more effective and less toxic than high doses of corticosteroid. We propose a regimen for treatment of Korean pemphigus patients based on these experiences. Further rnulti-center clinical trials are advocated to confirm an effective management protocol for Korean pemphigus patients.
Blister
;
Humans
;
Immunosuppressive Agents
;
Middle Aged
;
Mortality
;
Mucous Membrane
;
Pemphigus*
;
Prednisolone
;
Retrospective Studies
;
Skin
2.Comparison of D-PUVA with Conventional PUVA in the Treatment of Korean Psoriasis Patients.
Byung Soon PARK ; Hi Tae AN ; Jai Il YOUN
Korean Journal of Dermatology 1998;36(2):275-279
BACKGROUND: PUVA photochemotherapy has been accepted as an effective mode of treatment for psoriasis. Many combination therapies have been tried to reduce the possible adverse effects of long-term exposure to UV radiation. OBJECTIVE: This study was performed to compare calcipotriol-PUVA combination therapy(D-PUVA) with conventional PUVA in the treatment of Korean psoriasis patients. METHODS: We treated 38 Korean psoriasis patients with conventional PUVA and 12 with D-PUVA. We compared the total number, duration and total UVA dose of PUVA therapy to reach grade 4 between the two groups. We categorized each patient into clearing, improvement, or failure groups based on the therapeutic efficacy, and measured the PASI score at each of the patients visits. RESULTS: The total cumulative dose of D-PUVA phototherapy was significantly smaller than PUVA phototherapy. CONCLUSION: Combining PUVA with a vitamin D analogue, calcipotriol, in the treatment of psoriasis may lead to lowering the risk of long-term exposure to UV radiation with higher efficacy.
Humans
;
Photochemotherapy
;
Phototherapy
;
Psoriasis*
;
PUVA Therapy
;
Vitamin D
3.Treatment of flail chest with Judet's strut: 56 case report.
Byung Soon PARK ; Hong Kyu KIM ; Dong Jun LEE
The Korean Journal of Thoracic and Cardiovascular Surgery 1992;25(12):1523-1529
No abstract available.
Flail Chest*
4.Therapeutic effects of resperidone in the treatment of chronic schizophrenia.
Soon Won PARK ; Hae Ik CHUNG ; Byung Jo KANG
Journal of Korean Neuropsychiatric Association 1993;32(5):744-757
No abstract available.
Schizophrenia*
5.Treatment of flail chest with Judet's strut.
Byung Soon PARK ; Yong Jun CHO ; Dong Jun LEE
The Korean Journal of Thoracic and Cardiovascular Surgery 1991;24(4):366-370
No abstract available.
Flail Chest*
6.A clinical study of liver abscess.
Soon Hwa RHO ; Jin Hyun PARK ; Byung Cheol LEE
Journal of the Korean Surgical Society 1991;40(2):175-184
No abstract available.
Liver Abscess*
;
Liver*
7.The association of Vitamin D and Parathyroid Hormone with Bone Mineral Density in Korean Postmenopausal Women.
Won Cheol CHANG ; In Soon KWON ; Byung Joo PARK ; Sang Hoon BAE ; Sang Chul PARK
Journal of the Korean Geriatrics Society 2003;7(3):194-205
BACKGROUND: Osteoporosis results from bone loss due to menopause [estrogen(E) deficiency] and aging. Initial skeletal effect of menopause is accelerated bone resorption with an increase in seurm calcium(Ca) and compensatory but inadequate bone formation. Secretion of parathyroid hormone(PTH) is suppressed at this time. Postmenopausal osteoporosis results in fractures predominantly of trabecular bone, i.e., vertebra. With aging, secondary hyperparathyroidism by low serum Ca and vitamin D deficiency superim poses. Senile osteoporosis produces hip fractures, area of cortical bone. The aim of this study was to- examine the association of vitamin D[25(OH)D] and intact(i) PTH with bone mineral density(BMD) after controlling for suggested confounding factors, and the possibility of low serum vitamin D and high serum iPTH concentration could impact bone loss in Korean postmenopausal women. METHODS: Data from 188 postmenopausal Korean women aged 42 to 69 were analyzed through BMD, serum 25(OH)D, iPTH, Ca, phosphorus(P), alkaline phosphatase(ALP) and clinical characteristics. Factors affecting BMD was determined by Pearson correlation and the relationship between lumbar and femoral neck BMD and vitamin D[25(OH)D] and iPTH was assessed by multiple regression analysis after adjus- ting for suggested confounding factors. RESULTS: Lumbar and femoral neck BMD, serum Ca, P were decresaed and serum iPTH was increased with aging. In Pearson`s correlation, significant contributing factors to lumbar BMD was age, height, weight, menarche, year since menopause(YSM) and ALP. And significant contributing factors to femoral neck BMD was age, height, weight, menarche, YSM and iPTH. No relationship could be demonstrated between serum vitamin D[25(OH)D] and lumbar and femoral neck BMD. How ever, after controlling for potential confounding factors, a correlation was found between vitamin D[25(OH)D] and both of lumbar (p=0.013) and femoral neck BMD(p=0.077). iPTH was inversely related to femoral neck BMD(p=0.004) only in multiple linear regression. CONCLUSION: Serum vitamin D[25(OH)D] was influencing both of vertebral and femoral neck BMD, which suggests a significant role of vitamin D deficiency in the pathogenesis of postmenopausal osteo- porosis. In age related remodeling and loss of bone, increased serum iPTH might have additive role in cortical bone of femur. These findings suggest that vitamin D is very important for optimal bone health and a deleterious effect of increased iPTH on cortical bone loss. Adequate calcium and vitamin D status have to be maintained to prevent osteoporosis in postmenopausal Korean women.
Aging
;
Bone Density*
;
Bone Resorption
;
Calcium
;
Female
;
Femur
;
Femur Neck
;
Hip Fractures
;
Humans
;
Hyperparathyroidism, Secondary
;
Linear Models
;
Menarche
;
Menopause
;
Osteogenesis
;
Osteoporosis
;
Osteoporosis, Postmenopausal
;
Parathyroid Hormone*
;
Spine
;
Tolnaftate
;
Vitamin D Deficiency
;
Vitamin D*
;
Vitamins*
8.Brainstem auditory evoked potentials in infants below 6 months ofage.
Eun Sook PARK ; Chang Il PARK ; Jung Soon SHIN ; Byung Kuk CHO
Journal of the Korean Academy of Rehabilitation Medicine 1992;16(2):123-133
No abstract available.
Brain Stem*
;
Evoked Potentials, Auditory, Brain Stem*
;
Humans
;
Infant*
9.Does 'Hot Bath' have effect on experimental diabetic neuropathy?.
Won Ihl RHEE ; Seung Han YANG ; Young Shin PARK ; Byung Soon SHIN ; Keun Young PARK
Journal of the Korean Academy of Rehabilitation Medicine 1993;17(3):321-329
No abstract available.
Diabetic Neuropathies*
10.A case of primary of the follopian tube.
Byung Tae MOON ; Kwang Soon PARK ; Yong CHO ; Eui Sun RO ; Yong Pill KIM ; Soon Wook KWON
Korean Journal of Obstetrics and Gynecology 1993;36(7):3136-3143
No abstract available.