1.A Case Report of Traumatic Bilateral Bislocation of the Hip
Byung Yun HWANG ; Hyung Soon KIM
The Journal of the Korean Orthopaedic Association 1971;6(1):79-82
Bilateral dislocation of the hip was observed in a 44-year-old man after the accident that he was overrun from backward by a slowly approaching goods-train. Successful manual reduction was obtained, followed by one month cast immobilization and partial weight bearing exercise thereafter. Peroneal palsy of right extremity, noted immediately after the dislocation, showed the prospect of good recovery. The mechanism of injury was also discussed.
Adult
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Dislocations
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Extremities
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Hip
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Humans
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Immobilization
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Paralysis
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Weight-Bearing
2.A Case of Sacral Agenesis.
Cheol LEE ; Byung Uk PARK ; Tae Gyu HWANG ; Soon Yong LEE
Journal of the Korean Pediatric Society 1986;29(1):79-83
No abstract available.
3.A Case of Miescher Syndrome with Insulin-Resistant Diabetes Mellitus.
Byung Min CHOI ; Jong Kwang LEE ; Kee Hwang YOO ; Joo Won LEE ; Soon Kyum KIM
Journal of the Korean Pediatric Society 1994;37(9):1292-1295
Miescher syndrome comprises congenital acanthosis nigricans, hypertrichosis, failure to thrive and short stature, dysmorphism especially of the jaws and oral cavity, insulin-resistant diabetes mellitus, and a characteristic general appearance. This report concerns a rare case of 12-year-old girl having insulin resistant diabetic mellitus with Miescher syndrome. The relevant literature was reviewed.
Acanthosis Nigricans
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Child
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Diabetes Mellitus*
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Failure to Thrive
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Female
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Humans
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Hypertrichosis
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Insulin
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Jaw
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Mouth
4.Relationship of between blood lead level and lead related symptoms in low level lead exposure.
Kyu Yoon HWANG ; Jae Eog AHN ; Kyu Dong AHN ; Byung Kook LEE ; Joung Soon KIM
Korean Journal of Preventive Medicine 1991;24(2):181-194
This study intended to obtain an useful information on the prevalence of subjective symptoms, and to clarify the interrelationships between blood lead and lead related symptoms in low level lead exposure. The 93 male workers exposed to lead and 56 male nonexposed workers were examined for their blood lead (PBB), Zinc-protoporphy (ZPP), hemoglobin (HB) and personal history, and completed 15 questionnaires related to symptoms of lead absorption; also measured lead concentration in air (PBA) in the workplace. The results obtained were as follow; 1. The means of blood lead (PBB), blood ZPP and hemoglobin (HB) among workers exposed to lead were 26.1+/-8.8 microgram/dl, 28.3+/-26.0 microgram/dl and 16.2+/-1.2g/dl; whereas those of nonexposed workers were 18.7+/-5.1 microgram/dl, 20.6+/-8.7 microgram/dl and 17.3+/-1.1g/dl. The means of above three indicies between two groups showed significant difference statistically (p<0.05). 2. The means of blood lead (PBB), blood ZPP and hemoglobin of workers exposed to different lead concentration in air were as follows; When it was below 25 microgram/m3 , the indices were 24.7+/-79, 26.1+/-26.8 microgram/dl and 16.4+/-1.1 g/dl respectively; These indices were 27.1+/-8.5, 23.9+/-10.92 /dl and 16.2+/-1.3 g/dl when the lead concentration in air was 25~50 microgram/m3; and they were 3.4+/-9.3, 42.3+/-31.3 microgram/dl and 15.5+/-1.2 g/dl when the concentration of lead was above 50 microgram/m3. Although there were statistical difference in blood lead and hemoglobin among three different lead concentration in air, there was no statistical difference of blood ZPP among the three groups with different exposure levels (p>0.05). 3. The most frequently by complained symptom was "Generalized weakness and fatigue", and fewest symptom was "Intermittent pains in abdomen". 4. Only two symptoms out of fifteen symptoms checked by themselves revealed significant difference between exposed and nonexposed groups. These were "Intermittent pains of abdomen" and "Joint pain or arthralgia" (p<0.05). No positive correlation was found between the levels of blood lead and symptom groups categorized as gastrointestinal, neuromuscular and constitutional symptoms. 5. Blood lead (r=0.3995) and ZPP (r=0.2837) showed statistically significant correlation with mean lead concentration in air, whereas correlations were not demonstrated between blood lead and lead related symptoms or blood ZPP and lead related symptoms. 6. Blood lead (PBB) and ZPP showed association (r=0.2466) and the equation PBB=23.75+0.0842 ZPP was derived. 7. On stepwise multiple regression, using blood lead level as a dependent variable and ZPP, hemoglobin (HB), age, work duration (WD) and symptom prevalence as a independent variables, only ZPP significantly contributed a lot to blood lead level. 8. While the ZPP measurement was found to be a good indicator in evaluating health effect of lead absorption in low level lead exposure, lead related symptoms were not sensitive enough to evaluate of lead absorption in low level exposure.
Absorption
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Humans
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Male
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Prevalence
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Surveys and Questionnaires
5.Crush-Cleavage Fracture in Thoracolumbar and Lumbar Spine: Comparative Study with Type B Burst Fracture
Kyung Jin SONG ; Hak Ji KIM ; Ki Young CHANG ; Sang Soon CHOI ; Byung Yun HWANG
The Journal of the Korean Orthopaedic Association 1996;31(4):702-710
We noticed a group of thoracolumbar and lumbar spine fractures showing a unique fracture pattern that consisted of 1) superior disc injury, 2) crush fracture of the upper half of the vertebral body, 3) sagittal fracture of the lower half of the vertebral body, 4) bone fragments in the spinal canal, and 5) lamina fracture. Some of these fracture patterns were present in type B burst fracture of Denis classification. The purpose of this study was to compare the difference between crush-cleavage fracture and type B burst fracture in the viewpoint of neural canal involvement and neurologic status, and functional outcome with surgical treatment. Ten cases were identified as crush-cleavage fractures in 22 type B burst fractures during a 5 year period from Mar. 1989 to Jun. 1993 at the Department of Orthopedic Surgery of Chonbuk National University Hospital. Four out of 10 crush-cleavage fractures and 4 out of 12 type B burst fractures were paraparetic. Crush-cleavage fracture must be an unstable thoracolumbar comminuted fracture, but there were no significant differences in the neural canal involvement, incidence of neurologic deficit, and in the functional outcome, compared with type B burst fracture (P>0.05). It could be classified as a progressed form of type B burst fracture in Denis classification, or as a burst-split fracture in Magerl classification in the anatomical viewpoint. In conclusion, crush-cleavage fracture must be a variant of burst fracture.
Classification
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Fractures, Comminuted
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Incidence
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Jeollabuk-do
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Neural Tube
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Neurologic Manifestations
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Orthopedics
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Spinal Canal
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Spine
6.Non-Watertight Intermittent Dural Closure in Neurological Surgery.
Yong Woon CHO ; Jae Gon MOON ; Yong Soon HWANG ; In Suk PARK ; Byung Chan JEON ; Han Kyu KIM
Journal of Korean Neurosurgical Society 2000;29(5):640-643
No abstract available.
7.Genetic Transmission of Fibrodysplasia Ossificans Progressiva: Report of Two Cases in a Family.
Hyun Soon PYO ; Ho Kyeung HWANG ; Byung Moon PARK
Journal of the Korean Radiological Society 2001;45(2):201-205
Fibrodysplasia ossificans progressiva (FOP) is a rare connective tissue disorder characterized by congenital malformation of the great toes and by progressive heterotopic ossification of the tendons, ligaments, fasciae and skeletal muscles. We document the radiologic manifestation of FOP passed from a sporadically affected father to each of his two children (a son and a daughter). Previous consideration of a genetic etiology was based on the fact that the disease has been reported in several sets of monozygotic twins and that increased paternal age has been associated with sporadic occurrence of the disorder. Although autosomal-dominant transmission has long been suspected, the findings in this family provide confirmation for such inheritance and a basis for the diagnosis and counseling of patients with FOP.
Child
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Connective Tissue
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Counseling
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Diagnosis
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Fascia
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Fathers
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Humans
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Ligaments
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Muscle, Skeletal
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Myositis
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Myositis Ossificans*
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Ossification, Heterotopic
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Paternal Age
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Tendons
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Toes
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Twins, Monozygotic
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Wills
8.A case of intradural sparganosis in the thoracolumbar junction.
Jin Do HUH ; Young Duk JOH ; Byung Hee CHUN ; Yong Soon HWANG ; Hee Kyung CHANG ; Soo Bok SONG
Journal of the Korean Radiological Society 1991;27(4):509-512
No abstract available.
Sparganosis*
9.Hypoxia Increases the Expression of ICAM-1 in Cultured Human Synovial Fibroblasts.
Hyun Soon JEON ; Hong Sun BAEK ; Byung Yun HWANG ; Wan Hee YOO
The Journal of the Korean Rheumatism Association 2002;9(1):23-33
OBJECTIVE: Hypoxic conditions are thought to be exist in inflamed arthritic synovium.Several in vitro and in vivo studies indicate that hypoxia can initiate events that lead to pro-adhesive changes.Therefore,this study was designed to examine the effects of hypoxia on the expression of ICAM-1 by cultured human synovial fibroblasts. METHODS: Synovial fibroblasts were isolated from patients with RA and cultured at hypoxic condition.To quantify the expression of ICAM-1 mRNA in synovial fibroblasts,RT-PCR was performed.The levels of cytokines in culture supernatants were measured by ELISA.The activation of NF- Adhesives ; Anoxia* ; Cytokines ; Fibroblasts* ; Humans* ; Intercellular Adhesion Molecule-1* ; Interleukin-1 ; Lymphocytes ; RNA, Messenger ; Tumor Necrosis Factor-alpha
10.Cell Cylce Regulatory Effects of Cyclic AMP in Cancer Cells Which Lack Wild-type p53.
Joung Soon JANG ; Joung Hun KANG ; Byung Kiu PARK ; Sang Gu HWANG
Journal of the Korean Cancer Association 2000;32(4):750-756
PURPOSE: The activator of protein kinase A, cyclic AMP, has been a recognized growth inhibitor of certain cell types. The present study aimed to investigate the effects of dibutyryl cAMP on the growth of cancer cells which lack wild-type p53 and to determine the mechanism of growth inhibition. MATERIALS AND METHODS: Prostate and breast cancer cells were treated with dibutyryl cAMP and compared with untreated cells. Growth patterns of cells were assessed by trypan blue-excluding method and western blot was done to determine protein levels of cell cycle regulatory proteins which govern G1 and G1/S phase. Northern blot and immunoprecipitation were done to determine the level of mRNA of p21 and the association between cell cycle regulatory proteins. In vitro immune complex kinase assay was done to assess the activity of cdk2. RESULTS: cAMP reduced cell growth by 48 h. Cyclin D3 level was downregulated and RB protein level was decreased and mostly unphosphorylated forms remained. The association of RB with E2F1 was increased. While cdk2 levels remained constant throughout cAMP treatment, the activity of cdk2/cyclin E complex, which is responsible for entry into S phase, was downregulated. Cdk inhibitors, p27 and p21 were induced with cAMP treatment. CONCLUSION: These observation suggest that the growth inhibitory effects of dibutyryl cAMP on prostate and breast cancer cells were mediated by induction of cdk inhibitors such as p21 and p27 and RB activation in accordance with downregulation of cdk2.
Antigen-Antibody Complex
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Blotting, Northern
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Blotting, Western
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Breast Neoplasms
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Cell Cycle Proteins
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Cyclic AMP*
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Cyclic AMP-Dependent Protein Kinases
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Cyclin D3
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Down-Regulation
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Immunoprecipitation
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Phosphotransferases
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Prostate
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Retinoblastoma Protein
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RNA, Messenger
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S Phase