Vesiculobullous eruptions are a rare cutaneous manifestation of systemic lupus erythematosus (SLE). They are related to intense inflammation within the cutaneous lesions and subsequent blister formation. We report a case of vesiculobullous eruption of SLE in a 23-year-old male. The bullous eruptions were present ori the lip, forehead, both feet and hands. He met ARA(American Rheumatism Association) is criteria for a diagnosis of SLE and the eruptions developed during a systemic attack of the disease. Routine histology of the lesion showed subepidermal blisters with intact epidermis and dense neutrophilic infiltration in the upper dermis. Direct immunofluorescence of lesional skin showed a linear-granular pattern of immune deposits at the dermoepidermal junction. Electronmicroscopy of the lesional skin showing subepidermal bullae are located beneath the lamina densa. Combination therapy of prednisolone and hydrochloroquine showed complete clearing of the lesions within several weeks. We observed a good response without evidence of recurrence.
Blister ; Dermis ; Diagnosis ; Epidermis ; Fluorescent Antibody Technique, Direct ; Foot ; Forehead ; Hand ; Humans ; Inflammation ; Lip ; Lupus Erythematosus, Systemic* ; Male ; Neutrophils ; Prednisolone ; Recurrence ; Rheumatic Diseases ; Skin ; Young Adult

No abstract available.
Antibodies, Neutralizing* ; Feces* ; Rotavirus*

No abstract available.
Aspergillosis* ; Child* ; Humans ; Leukemia

A 38-year-old woman showed pruritic reddish patches, plaques and an indurated mass of 6 year's duration on the face, trunk, back, upper and lower extremities. Histopathological and immunohistochemical findings suggested the diagnosis of mycosis fungoides (tumor stage). She was treated with chemotherapy(CVP regimen) with a mild resolution. Then 6 months later, a skin lesion on the forehead developed in to a tumorous lesion and the truncal lesions got worse. So we tried combination therapy with Retinoid(etretinate 0.5mg/kg/day) and PUVA (Total dose of 228 joules/cm(2)) for 7 months. After 7 months, marked improvement of the skin lesions was noticed. The combination of Retinoid and PUVA was considered a good therapeutic trial for mycosis fungoides of the early advanced stage.
Adult ; Diagnosis ; Female ; Forehead ; Humans ; Lower Extremity ; Mycosis Fungoides* ; Skin

Mitochondria are complex metabolic organelles with manifold pathophysiological implications in diabetes. Currently published mitochondrial-encoded peptides, which are expressed from the mitochondrial open reading frame of the 12S ribosomal RNA type-c (MOTS-c), 16S rRNA (humanin and short humanin like peptide 1-6 [SHLP1-6]), or small human mitochondrial open reading frame over serine tRNA (SHMOOSE) are associated with regulation of cellular metabolism and insulin action in age-related diseases, such as type 2 diabetes mellitus. This review focuses mainly on recent advances in MOTS-c research with regards to diabetes, including both type 1 and type 2. The emerging understanding of MOTS-c in diabetes may provide insight into the development of new therapies for diabetes and other age or senescence-related diseases.

BACKGROUND AND OBJECTIVES: Some objective and quantitative diagnositc methods are introduced to evaluate vocal cord paralysis, such as electro glottography (EGG) and laryngeal electromyography (LEMG). LEMG is an invasive and highly technical method requiring patient's cooperation. It records action potential generated when intrinsic laryngeal musculature contracts. EGG, on the other hand, records changes of impedence between both vocal cords when theses vibrate and represents many information of vocal cord movements. This method is non-invasive and very simple offering some valuable information about voice function of laryngeal diseases. MATERIALS AND METHODS: From January 1998 through May 2000, we evaluated 15 vocal cord paralysis patients by LEMG and EGG and compared the usefulness of these two methods by determining the lesions of vagal nerve injury. RESULTS: For patients who had severe recurrent laryngeal nerve injuries, EGG and dEGG showed no plateau phase but a loss of two-mass movements. Some showed very irregular saw-tooth shaped wave patterns. Patients with vagal nerve injury, EGG and dEGG showed relatively well maintained plateau phases because they had paralyzed cricothyroid muscles which are counteract to abductor of vocal cord. CONCLUSION: Although EGG did not provide information about such diseases as laryngeal myopathy and arthropathy, it is simple and non-invasive, and may he much valuable as a topodiagnostic method of vocal cord paralysis.
Action Potentials ; Diagnosis* ; Electromyography ; Hand ; Humans ; Laryngeal Diseases ; Laryngeal Muscles ; Muscular Diseases ; Ovum ; Recurrent Laryngeal Nerve Injuries ; Vocal Cord Paralysis* ; Vocal Cords* ; Voice

PURPOSE: To evaluate the clinical results between interlocking intramedullary nail with fibular fixation and nail only for treating distal tibiofibular diaphyseal fractures. MATERIALS AND METHODS: From March 2003 to September 2006, 19 distal tibiofibular fractures were antegrade nailed after anatomical reduction and fixation of fibular fractures, and another 37 fractures fixed with nails only. Average age of patients was 48.6 years. These two groups were compared by VAS (visual analogue scale)&ankle ROM according to degree of comminution and fracture configuration. The statistical analysis was evaluated by t-test. RESULTS: There was no statistical difference between fibular fixation group and non-fixation group in VAS score according to fracture comminution and configuration (p>0.05). However, compared according to fracture configuration, mean ankle eversion of fibular fixation group in oblique fractures was 18.3 degrees, and that of non-fixation group was 12.5 degrees (p<0.05). In addition, mean ankle plantar flexion, dorsiflexion, inversion and total ankle ROM of fibular fixation group in spiral fractures was 40.0, 20.0, 30.0 and 108.3 degrees of each and that of non-fixation group was 38.3, 18.5, 27.0 and 101.7 degrees (p<0.05). CONCLUSIONS: In oblique and spiral fractures of distal tibiofibular diaphysis, interlocking intramedullary nail with fibular fixation had the advantage in postoperative ankle ROM. So, it can be a worthy method for the treatment of distal tibiofibular diaphyseal fractures.
Animals ; Ankle ; Diaphyses ; Fracture Fixation, Intramedullary ; Humans ; Imidazoles ; Nails ; Nitro Compounds

Mass screening for detecting both thyroid and breast cancer in adult women was carried out in Samsung Cheil Hospital between March 31, 1996, and March 31, 1997. The total number of subjects during those 13 months was 3869. At first, the screening was by inspection and palpation using experienced surgeons. Thyroid abnormalities were found in 183 subjects through physical examination but thyroid nodules were identified by thyroid sonography in only 170 patients who were required to undergo a cytologic examination (FNAB). The total number of thyroid cancer cases detected was 23. The detection rate was 0.59%. In contrast, 8 cases of breast cancer were discovered during the same screening, with a detection rate of 0.21%. The size of the thyroid tumor was 2 cm or less in 20 patients (87%). The thyroid cancers detected by mass screening were discovered at an earlier stage and will show a better survival rate. As thyroid cancer can be found at an earlier stage by mass screening, the program is useful for the early detection and early treatment of thyroid cancer.
Adult ; Breast Neoplasms ; Female ; Humans ; Mass Screening* ; Palpation ; Physical Examination ; Survival Rate ; Thyroid Gland* ; Thyroid Neoplasms* ; Thyroid Nodule

CCR3 is a chemokine receptor that mediates the accumulation of allergic inflammatory cells, including eosinophils and Th2 cells, at inflamed sites. The regulatory sequence of the CCR3 gene, contains two Runt-related transcription factor (RUNX) 1 sites and two PU.1 sites, in addition to a functional GATA site for transactivation of the CCR3 gene. In the present study, we examined the effects of the cis-acting elements of RUNX1 and PU.1 on transcription of the gene in EoL-1 eosinophilic cells and Jurkat T cells, both of which expressed functional surface CCR3 and these two transcription factors. Introduction of RUNX1 siRNA or PU.1 siRNA resulted in a modest decrease in CCR3 reporter activity in both cell types, compared with transfection of GATA-1 siRNA. Cotransfection of the two siRNAs led to inhibition in an additive manner. EMSA analysis showed that RUNX1, in particular, bound to its binding motifs. Mutagenesis analysis revealed that all point mutants lacking RUNX1- and PU.1-binding sites exhibited reduced reporter activities. These results suggest that RUNX1 and PU.1 participate in transcriptional regulation of the CCR3 gene.
Eosinophils ; Mutagenesis ; RNA, Small Interfering ; T-Lymphocytes ; Th2 Cells ; Transcription Factors ; Transcriptional Activation ; Transfection

There are few reports on intraneural ganglion, and this malformations mainly occurs in peripheral nerves of the upper and lower extremities. In the lower extremity, it often occurs in the common peroneal nerve, with neurologic symptoms such as motor weakness and sensory changes. We experienced a case of intraneural ganglion of the common peroneal nerve around the fibular head and this was associated with neurologic symptoms, including weakness of the motor power in the ankle and great toe dorsiflexion and sensory change in the foot dorsum. It was successfully treated by complete excision. We report here on this unusual case and we review the relevant literature.
Animals ; Ankle ; Foot ; Ganglion Cysts ; Head ; Lower Extremity ; Neurologic Manifestations ; Paralysis ; Peripheral Nerves ; Peroneal Nerve ; Toes