A number of tissues have been studied in the past with respect to their organ-specific antigens. In many instances it has been possible to produce autoantibodies against characteristic components. The testis, epididymis, and seminal plasma have been largely explored from this angle. Interest in the field of accessory glands began many years ago, when the first cross-reactions between extracts of prostate, seminal vesicles and seminal plasma were demonstrated. As a consequence, the possibility that some seminal plasma antigens might be present in the accessory glands before being secreted into the genital tract opened up a new approach to possible autoimmunologic damage of these glands and of seminal spermatozoa as well. The purpose of this study is made to observe the effect of homologous epididymal extracts on the spermatogenesis in mouse. Isoimmunization with extracts of mouse epididymis, administered with complete Freund`s adjuvant, has been performed in this study.The results were as follows: 1. The histological observations revealed that spermatogenesis was adversely affected by the immunization with homologous epididymal extract added with an equal amount of complete Freund's adjuvant for 6 weeks. It was observed that spermatogenesis was remarkably impaired in the experimental group whereas it was unaffected in the control group of male mouse. The results further indicated that the degeneration and exfoliation were found in the germinal cell of seminiferous tubules and in the epithelium of the epididymal ducts besides intercanalicular infiltration of m0nonuclear round cells. 2. The cross-reactions between extracts of epididymis and testicular tissues were demonstrated in mouse. 3. The immunological examination such as immune diffusion test and sperm agglutination test showed negative reaction on all of the experimental animals in this study. Therefore. the immunological change in this experiments seems to be caused by cell mediated immunity.
Animals ; Autoantibodies ; Diffusion ; Epididymis ; Epithelium ; Freund's Adjuvant ; Humans ; Immunity, Cellular ; Immunization ; Male ; Mice* ; Prostate ; Semen ; Seminal Vesicles ; Seminiferous Tubules ; Sperm Agglutination ; Spermatogenesis* ; Spermatozoa ; Testis

No abstract available.
Dialysis* ; Korea*

The histopathological observation was made on 48 cases of benign prostatic hypertrophy which had been admitted to the Department of Urology, Chung-Ang University Hospital from January, 1971 to December, 1981. The results were as follows: 1. Histopathologically the fibromyoadenomatous type was 22 cases (45.8%) and the fibroadenomatous type 17 cases (35.4%), the fibromuscular type 9 cases (16.7%), muscular type 1 case (2.1%). There was no special difference between each histopathological type in age distribution. 2. Mean size of removed prostatic tissue was 81.1cm3 in fibroadenomatous type, 71.8cm3 in fibromyoadenomatous type, 25.0cm3 in muscular type, 20.0cm3 in fibromuscular type. The type of which weight was more than 50 gm was fibromyoadenomatous type. 3. Additional lesion such as inflammation, infarction or cancer was notedin I6 cases (31.9%). Inflammatory Change were present in 4 cases of fibromyoadenomatous hyperplasia and in 3 cases of fibroadenomatous hyperplasia. Infarction was seen in 2 cases of fibromyoadenomatous hyperplasia and in 1 case of fibromuscular hyperplasia. Latent cancer was found in 2 cases of fibromyoadenomatous hyperplasia and in 2 cases of fibroadenomatous hyperplasia. Inflammatory changes and latent cancer were present only in adenomatous hyperplasia and infarction in fibromuscular hyperplasia.
Age Distribution ; Hyperplasia ; Infarction ; Inflammation ; Prostatic Hyperplasia* ; Urology

No abstract available.
Dialysis* ; Korea*

No abstract available.
Clone Cells* ; Cloning, Organism* ; Thymidine*

We report a case of plexiform neurofibroma developed under the overlying speckled lentiginous nevus, which occurred in a 20 year-old man. In this patient and his family no other signs of von Recklinghausens disease were found. Discussion is focussed on the fact that both plexiform neurofibroma and speckled lentigmous nevus, which represent a defect in the neural crest, occurred in the same area of the skin.
Humans ; Neural Crest ; Neurofibroma, Plexiform* ; Neurofibromatosis 1 ; Nevus* ; Skin

We report a case of secondary anetoderma due to pilomatricoma. A 15-year-old girl presented with a soft, 1.5 × 1.5cm in size, atrophic, pinkish and bulged-out lesion overlying the palpable subcutaneous mass on the left upper arm for several months. Histologic examination revealed the reduced number of dermal elastic fibers overlying a typical pilomatricoma.
Adolescent ; Anetoderma* ; Arm ; Elastic Tissue ; Female ; Humans ; Pilomatrixoma*

We report a case of secondary anetoderma due to pilomatricoma. A 15-year-old girl presented with a soft, 1.5 × 1.5cm in size, atrophic, pinkish and bulged-out lesion overlying the palpable subcutaneous mass on the left upper arm for several months. Histologic examination revealed the reduced number of dermal elastic fibers overlying a typical pilomatricoma.
Adolescent ; Anetoderma* ; Arm ; Elastic Tissue ; Female ; Humans ; Pilomatrixoma*

No abstract available.
Skin Diseases*

Hemimegalencephaly is an uncommon sporadic congenital malformation of the central nervous system characterized by enlargement of one cerebral hemisphere with cranial asymmetry, hemiparesis, epilepsy, and mental retardation. This report deals with a 12-month-old girl with intractable seizure and developmental delay, who revealed hemispheric asymmetry and enlarged right cerebral hemisphere. MRI scan revealed asymmetric enlargement of right cerebral hemisphere with lissencephaly and multifocal calcification. She underwent right frontal lobectomy and parietal cortical resection, but died of complication of surgery. Histological features included loss of cortical lamination, large atypical neurons, neuronal heterotopia, and astrocytosis with dystrophic calcification. The heterotopic neurons in the white matter were suggestive of aberrant neuronal migration.
Central Nervous System ; Cerebrum ; Epilepsy ; Female ; Gliosis ; Humans ; Infant ; Intellectual Disability ; Lissencephaly ; Magnetic Resonance Imaging ; Malformations of Cortical Development* ; Neurons ; Paresis ; Rabeprazole ; Seizures