1.Adult-onset Kawsaki Disease Complicated by Splenic Infarction and Coronary Aneurysm.
Byung Kwan CHO ; Seong Ryul KWON ; Seung Jai YOON ; Moon Hyun CHUNG ; Sun Nyuh LEE ; Sang Hyun LEE
Korean Journal of Infectious Diseases 2000;32(5):388-392
Kawasaki disease or mucocutaneous lymph node syndrome is an acute inflammatory illness of childhood characterized by systemic panvasculitis. It presents with high fever, dramatic changes of the skin and mucous membranes, and lymphadenopathy. Adult-onset Kawasaki disease is rare and reports on coronary involvement in adult are even rarer. Herein, we report a case of adult-onset Kawasaki disease complicated by splenic infarction and development of coronary aneurysm even despite of treatment with intravenous gamma globulin. A 20-year-old man presented with fever, erytheatous rash, induration and desquamation of hands and feet, pulmonary edema and shock due to cardiomyopathy, splenic infarction, bilateral conjunctivitis, jaundice, and cervical lymphadenopathy. After Kawasaki disease was suspected, intravenous gamma globulin (2 g/kg once) and aspirin (6 g/day) were administered. On the 30th hospital day, transesophageal echocardiography showed one coronary aneurysm and coronary angiography showed three aneurysms. Eight months after the first admission, follow-up coronary angiography showed normalization of the previous coronary abnormalities.
Adult
;
Aneurysm
;
Aspirin
;
Cardiomyopathies
;
Conjunctivitis
;
Coronary Aneurysm*
;
Coronary Angiography
;
Echocardiography, Transesophageal
;
Exanthema
;
Fever
;
Follow-Up Studies
;
Foot
;
gamma-Globulins
;
Hand
;
Humans
;
Jaundice
;
Lymphatic Diseases
;
Mucocutaneous Lymph Node Syndrome
;
Mucous Membrane
;
Pulmonary Edema
;
Shock
;
Skin
;
Splenic Infarction*
;
Young Adult
2.Surgical Treatment of Popliteal Artery Injury as a Complication of Arthroscopic Surgery: 2 case reports.
Kilsoo YIE ; Se Min RYU ; Seong Joon CHO ; Byung Ryul CHO ; Bong Ki LEE
The Korean Journal of Thoracic and Cardiovascular Surgery 2008;41(6):772-776
The indications and applications of arthroscopic surgery for the knee joint have increased with the development in surgical techniques and the improvement of arthroscopic equipment. The use of arthroscopic surgery has led to a significant decrease in morbidity for the patient with intra-articular abnormalities, in terms of both the diagnosis and the surgical treatments. Even though arthroscopy is a minimally invasive technique with relatively low morbidity, it is not without risk of complications, of which neurovascular complications are among the most serious and devastating. Here we report on 2 cases of popliteal artery injury during arthroscopic knee surgery and its specific diagnosis and treatment.
Arthroscopes
;
Arthroscopy
;
Humans
;
Knee
;
Knee Joint
;
Popliteal Artery
3.A Case of Perinatal Lethal Osteogeenesis Imperfecta.
Sung Lyul JANG ; Yong Soo CHO ; Byung Wan KIM ; Sung Ryul HONG ; Jung Yup PARK ; Yoon Jung PARK ; Jong Hak LEE
Korean Journal of Perinatology 1997;8(1):55-59
Osteogenesis imperfecta is a rare congenital disease. It is a heterogeneous group of inherited disorders characterized by multiple bone fracture, blue sclera, hearing loss, abnormalities of dentition and widespread connective tissue ahnormality. We experienced a case of osteogenesis imperfecta diagnosed in utero by ultrasonogram and confirmed hy postnatal radiograph after delivery. We present the case with a hrief review of the literature.
Connective Tissue
;
Dentition
;
Fractures, Bone
;
Hearing Loss
;
Osteogenesis Imperfecta
;
Sclera
;
Ultrasonography
4.Dysphagia Secondary to Esophageal Compression in a Patient with Decompensated Heart Failure
Jintae PARK ; Sora BAEK ; Gowun KIM ; Seung-Joo NAM ; Byung-Ryul CHO
The Korean Journal of Helicobacter and Upper Gastrointestinal Research 2022;22(2):146-151
Cardiogenic dysphagia is a rare type of esophageal dysphagia caused by external compression of the esophagus by an enlarged left atrium. Long-term comparisons between the degree of cardiogenic dysphagia and heart failure have not been reported due to its low incidence. We hereby report the case of a 74-year-old woman with valvular heart disease, suspected of having oropharyngeal dysphagia following a recent intracerebral hemorrhage, who performed a swallowing function test. Videofluoroscopic swallowing study (VFSS) revealed a supraglottic penetration, confirming the oropharyngeal dysphagia. Furthermore, post-VFSS chest radiograph revealed esophageal residual barium, suggestive of reduced esophageal food transition secondary to external compression, at the level of the T6 vertebral body. Chest computed tomography showed mid-esophageal compression caused by left atrial enlargement. She had pulmonary edema which was managed with diuretics. Post-VFSS chest radiographs also revealed a direct association between the diameter of the esophageal barium residue and body weight. A reduction in body weight led to the resolution of the barium residue and vice versa. Development of cardiac dysphagia may be one of the signs of acute exacerbation of heart failure.
6.Intrathecal Synthesis of Immunoglobulin G (IgG) and Anti-Tbc Humoral Immune Response in the Tuberculous Meningitis.
Tae Young CHO ; Yun Joong KIM ; Soo Chul PARK ; Byung In LEE ; Sang Nae CHO ; Hong Ryul LEE ; Sei Kyu KIM ; Sung Kyu KIM
Journal of the Korean Neurological Association 1993;11(1):54-61
The Immunological diagnosis of tuberculous meningitis (TBM) requires the presence of de novo synthesis of immunoglobulin in the central nervous system. We investigated the CNS IgG synthetic rate and IgG antibody titers against lipoarabinomanan (LAM) and PPD antigens in the serum and CSF by using ELISA in patients with TBM and patients with only pulmonary tuberculosis (PTB). The CNS IgG synthetic rate was markedly increased in all 11 patients with TB with PTB (56.42+l886 mg/day vs 7.47+435 mg/day). On the other hand, abnormally elevated IgG titers in the CSF against either LAM or PPD antigen were present in all 7 patients with TBM and in 4 of 11 patients with PTB tested. The 4 patients with the false positivity showed markedly elevated IgG antibody titers in the sera suggesting the passive diffusion of IgG antibodies through the intact blood brain barrier from the sera to the CSF. It is likely that the simultaneous measurement of CNS IgG sythesis is an useful addition to the ELISA of IgG antibody titration against the antigens of M. tuberculare in the CSF for the accurate diagnosis of TBM, especially in the endemic area of tuberculosis.
Antibodies
;
Blood-Brain Barrier
;
Central Nervous System
;
Diagnosis
;
Diffusion
;
Enzyme-Linked Immunosorbent Assay
;
Hand
;
Humans
;
Immunity, Humoral*
;
Immunoglobulin G*
;
Immunoglobulins*
;
Immunologic Tests
;
Tuberculosis
;
Tuberculosis, Meningeal*
;
Tuberculosis, Pulmonary
7.A Case of Dengue Hemorrhagic Fever Imported from Africa.
Seong Ryul KWON ; Byung Kwan CHO ; Seung Jai YOON ; Yong Bum CHO ; Il Kwon KIM ; Byong Joon PARK ; Moon Hyun CHUNG
Korean Journal of Infectious Diseases 2000;32(6):467-469
Dengue hemorrhagic fever/dengue shock syndrome (DHF/DSS) is an acute febrile illness characterized by hemorrhagic phenomenon and hypovolemic shock due to increased vascular permeability and plasma leakage in patients infected with any one of four serotypes of dengue virus. The disease is one of the principal causes of hospitalization and death among children in several south-east Asian, central and south American, and African countries. With increasing use of air or ship transport, more travelers and sailors to the tropics are returning within the incubation period of acute febrile infection. Herein we reported the first Korean case of dengue hemorrhagic fever imported from Africa. We experienced a Korean sailor who complains of fever, chill, nausea, and epistaxis after the return from Mombasa, Kenya. His fellows also showed the similar complains. His illness improved spontaneously and the indirect immunofluorescent antibody testing revealed antibody titer of 1:1024 or more.
Africa*
;
Asian Continental Ancestry Group
;
Capillary Permeability
;
Child
;
Dengue Virus
;
Dengue*
;
Epistaxis
;
Fever
;
Hospitalization
;
Humans
;
Kenya
;
Military Personnel
;
Nausea
;
Plasma
;
Severe Dengue*
;
Ships
;
Shock
8.Cell Surface Tissue Transglutaminase-induced Activation of Phosphoinositol 3-Kinase/Akt Pathway.
Seung Oh KIM ; Min Kyung KIM ; Seung Su LEE ; Byung Ryul CHO ; Dae Joong KIM
Korean Journal of Physical Anthropology 2009;22(3):245-254
Multifunctional tissue transglutaminase (tTGase) is found in the cytoplasm and cell surface, as well as in the extracellular matrix. However, it is difficult to determine the exact function of tTGase in each cell compartment. This study focused on the potential role of cell surface tTGase in the process of "outside-in" signal transduction. Immunofluorescence study and western blotting was performed to localize the overexpression of tTGase. tTGaseoverexpressed H9c2/tTGase cells were treated with anti-tTGase antibody to evaluate the potential functions of tTGase on the outside-in signal process. The tTGase level markedly increased in each cell compartment and the culture media of H9c2/tTGase cells that show overexpression of tTGases. Anti-tTGase monoclonal antibody reduced tTGase levels in the whole lysate of H9c2/tTGase cells, and concomitantly increased the activity of the Akt. The results suggest that the cell surface expression of tTGase may be associated with an intracellular signaling pathway via the phosphoinositol-3 kinase/Akt. Phosphorylation of mitogen activated protein kinase family, ERK1/2, and Jun N-terminal Kinase (JNK), was also inhibited in the anti-tTGase antibody-treated H9c2/tTGase cells. These results suggest that cell surface tTGase may regulate intracellular signaling pathways in an autocrine or paracrine manner.
Blotting, Western
;
Culture Media
;
Cytoplasm
;
Extracellular Matrix
;
Fluorescent Antibody Technique
;
GTP-Binding Proteins
;
Humans
;
Phosphorylation
;
Phosphotransferases
;
Protein Kinases
;
Signal Transduction
;
Transglutaminases
9.Obstructive Pneumonia due to Unknown Eosinophilic Mucoid Impaction of Bronchi: a Case Report.
Jae Wan JUNG ; Ki Eun HWANG ; Ki Chang SOHN ; Byung Hun LIM ; Kyung Hwa CHO ; Hak Ryul KIM ; Eun Taik JEONG
Korean Journal of Medicine 2015;89(6):699-703
We report an unusual case of obstructive pneumonia due to an unknown eosinophilic mucoid impaction of the bronchi (MIB). A 54-year-old woman visited our hospital for investigation of abnormal shadows visible on a chest radiograph. Chest computed tomography and bronchoscopic examination revealed pneumonia due to MIB. Histopathological examination of biopsied mucosal tissue revealed extensive eosinophilic infiltration. With the exclusion of medical diseases that can cause eosinophilia, pneumonia due to eosinophilic mucoid impaction of the bronchi was diagnosed. The cause of the eosinophilia remained unknown. The pneumonia and mucoid impaction resolved after oral steroid therapy.
Bronchi*
;
Eosinophilia
;
Eosinophils*
;
Female
;
Humans
;
Middle Aged
;
Mucous Membrane
;
Pneumonia*
;
Radiography, Thoracic
;
Thorax
10.The Feasibility of Platelet-Rich Fibrin Matrix Filler in a Nude Mouse Model.
Hyeon Jun JEON ; Dong Kyu KIM ; Jeong Woo LEE ; Kang Young CHOI ; Ho Yun CHUNG ; Byung Chae CHO ; Jun Ho SHIN ; Seung Ryul LEE ; Jung Dug YANG
Archives of Aesthetic Plastic Surgery 2017;23(3):135-142
BACKGROUND: In contrast to fillers made from artificial substances, platelet-rich fibrin matrix (PRFM) filler does not cause hypersensitivity reactions or foreign body reactions. PRFM is also highly accessible in terms of cost. Hence, in this study, the efficacy of PRFM for soft tissue augmentation and volume maintenance was evaluated in an animal experiment. METHODS: Twenty nude mice were injected with hyaluronic acid filler, fibrin glue, PRFM filler, and normal saline (control). The remaining volume was measured 4 times over the course of 8 weeks using the volumetric taping bowl method and magnetic resonance imaging. RESULTS: All nude mice survived and showed no signs of infection, such as erythema or edematous changes, during the study period. Migration of the injected substance was not detected at 2, 4, or 8 weeks after the procedure. The remaining volumes of normal saline at 2, 4, and 8 weeks were 10.50%, 2.00%, and 0.00%; fibrin glue, 20.50%, 9.00%, and 2.50%; hyaluronic acid filler, 82.00%, 35.00%, and 17.33%; and PRFM filler, 70.31%, 26.75%, and 14.37%, respectively. CONCLUSIONS: PRFM filler had a high soft-tissue filling capacity compared with the control. It also showed a similar effect to hyaluronic acid filler. Thus, PRFM filler could be a good alternative for correcting soft-tissue deficits.
Animal Experimentation
;
Animals
;
Cosmetic Techniques
;
Erythema
;
Fibrin Tissue Adhesive
;
Fibrin*
;
Foreign Bodies
;
Hyaluronic Acid
;
Hypersensitivity
;
Magnetic Resonance Imaging
;
Methods
;
Mice
;
Mice, Nude*
;
Platelet-Rich Plasma