Granuloma annulare is a benign, usually self-limited chronic dermatasia of unknown cause, charaeterized by akin colored papules that may be arranaged in an annular configuraticn. Histopathologically, it is charicterized by camplete or incomplete foeal degeneration of collagen of chronic infliammatory cells. The authors obaerved an atypical case of granuloma annulare in a 4-year-old girl. She showed multiple papules and nodule on hands and feet. On inital examination, her skin lesions suggested histiacytosis, xanthanulama, rheumatoid nodule, or benign skin tumor. But the skin biopey revealed typica1 findings of granuloma awulare. Focal degeneration of colagen was confirmed by toluictine blue stain. Her skin lesions were almoatly cleared by skin biopsy and intralesional injectian of corticosteroid.
Biopsy ; Child, Preschool ; Collagen ; Female ; Foot ; Granuloma Annulare* ; Granuloma* ; Hand ; Humans ; Rheumatoid Nodule ; Skin

The nail has been considered to be the best human model to evaluate the general body state at all ages. The present study was disigned to measure the nail growth rate and to define the correlation of them with other values of nail size. The subjects were 373 males and 812 females whose ages from R months to 79 years. The results were as follows: 1. The linear elongation of the nails were most rapid in the 14 to 15 year-old age group. It decreased steadily as the subjects got older and olr1er. 2. Sex differences in the nail growth rate were not statistically significant. R. Where were no statistically significant differences in the linear growth rate of nails between right and left hands. 4. The middle finger nail grew more quickly than others, while the thumb and little finger nails grew more slowly. 5. Linear growth of nails were not significantly correlated to the thickness and length of nails and the length of lunulae.
Adolescent ; Female ; Fingers ; Hand ; Humans ; Male ; Pityriasis Lichenoides* ; Pityriasis* ; Sex Characteristics ; Thumb

Cheilitis granulomatosa is a macrocheilia having a sudden onset and a progresaive eourse that terminates in chronic enlargement of the lips. Labial enlargement can occur alone or in combination with intermittent facial paralysis and fissured tongue. The traid of abnormalities has been termed the Melkersaon-Rosenthal syndrome. The term, cheilitis granulomatosa, is now generally accepted as the description of the labial conditian with or without the other components of the triad. We have experiegced a case of cheilitis granulomatosa in a 23-year-old man and excellent result were obtained after local triamcinolone acetonide injections. On the first examination, the upper lip was estimated at approximately twice the normal size and the tongue was moderatedly furrowed. The consistency was elastic, but firm due to the nan pitting edema of the entire upper lip. We have treated him with intralesional injections of triamcinolone acetonide. Total injeetions were fifteen times in 6 months period. After the treatment, climcally ohaerved ehanges eonsisted of a decrease in lip volume, diminished edema plus a gradual softening of lip texture.
Cheilitis* ; Edema ; Facial Paralysis ; Humans ; Injections, Intralesional ; Lip ; Melkersson-Rosenthal Syndrome* ; Tongue ; Tongue, Fissured ; Triamcinolone Acetonide ; Young Adult

No abstract available.
Humans

Basal cell epithelioma arising from epidermis and its appendages is a common skin tumor. But multiple occurence of basal cell epitheliomas and that of arising in an epidermal nevi are extremely rsre. Since the first report by Toyama and Kojima in 1937, only few cases were reported in the world literatures. We observed a case of multiple basal cell epitheliomas arising in an epidermal nevi in a 54-year-old female patient who had rhomboidal verrucous patch on the right side of the cheek and arciform erythematous verrucous eruption from the right side of the eyebrow to the lower eyelid. Clinical features were not compatible with any type of basal cell epithelioma. But histological finding revealed basal cell epithelioma with epidermal nevi. Literatures were briefly reviewed.
Carcinoma, Basal Cell* ; Cheek ; Epidermis ; Eyebrows ; Eyelids ; Female ; Humans ; Middle Aged ; Nevus* ; Skin

We report herein two cases of nevus comedonicus. The first case was developed in the scalp, and the second case was in the right side of breast. In the first case, the lesion of the scalp was completely excised.
Breast ; Nevus* ; Scalp

No abstract available.
Child* ; Humans ; Mycoplasma pneumoniae* ; Mycoplasma* ; Pneumonia, Mycoplasma*

No abstract available.
Gonadal Dysgenesis, Mixed*

Recently, methionyl-hGH was produced in the E. coil K-12, W3110 by recombinant DNA technology in Korea. In this paper, the clinical efficacy and immunogenicity of this GH were studied in 43 patients with growth hormone deficency.The subjects of this study were aged 4.3-18.5 years and each patient received GH 0.5-0.71U/kg week subcutaneously, 6-7 times a week for 1 year. During treatment, height, body weight and bone age were checked. Blood count, urinalysis, blood chemistry and thyroid hormonal concentrations were checked before and every 3 months. The measurement of IGF-1 was performed and assay of antibody against hGH was performed before and every 6 months.The height velocities significantly increased from 3.7+-3.0 cm/year to 11.0+-4.2 cm/year and 9.9+-3.2 cm/year at 6 and 12 months after GH therapy, respectively. The Height SDS were significantly improved after GH therapy with increasing ratio of bone age to chronological age from 0.60+-0.19 at pretreatment to 0.68+-0.16 at 6 month, 0.69+-0.16 at 12 month of therapy. The plasma IGF-1 levels significantly increased during treatment. Three out of 35 patients(8.3%) showed antibody against hGH after 1 year of treatment. Thoughout study, we could not observe any remarkable side effect with GH treatment.These results indicate that this E. coli derived methionyl recombinant growth hormone is effective in improving the index of linear growth in the children with growth hormone deficiency without significant side effect.
Body Height ; Chemistry ; Child ; DNA, Recombinant ; Growth Hormone ; Human Growth Hormone ; Humans ; Insulin-Like Growth Factor I ; Korea ; Plasma ; Thyroid Gland ; Treatment Outcome ; Urinalysis

No abstract available.
Female ; Pregnancy ; Pregnancy, Ectopic*