The series comprised 424 cutaneous reactions to drugs treated at the department of Dermatology, Medical college of Korea University, during the years 1969-1975. The whole series comprised 211 male(49. 8%) and 213 female(50. 2%) patients. Exanthernatous eruptions are the most frequent of all cutaneous manifestation of drug reactions. Antipyretic analgesics, antibiotics and antibacterial drugs were the three group inducing most drug reactions in the present study, following by herb drugs. Of the antipyretic anaIgesics, acetylsalicylic acid was the ones most of the involved, and sulfonamides were the most frequent cause of skin reactions induced by antibacterial drugs and penicillin and tetracycline were the frequent cause of skin reactions induced by antibiotics.
Analgesics ; Anti-Bacterial Agents ; Aspirin ; Dermatology ; Drug Eruptions* ; Humans ; Korea ; Penicillins ; Skin ; Sulfonamides ; Tetracycline

To determine the concentration and the physiologic role of metal components in blood plasma and seminal plasma in relation to male infertility, the concentrations of twelve metal components in blood plasma and seminal plasma including Na, Mg, K, Ca, Cr, Mn, Fe, Cu, Zn, Se, Cd and Pb were measured by atomic absorbance spectrophotometery or ion selective electrode analysis. Semen and blood samples were obtained from a total of 110 men including 70 male infertility patients, 20 vasectomized persons and 20 fertility proven volunteers visited to the Male Infertility Clinic of Pusan National University Hospital. The concentrations of Ca, Zn, Mg, Cr and Cd in control group were higher in seminal plasma than in blood plasma, and additionally Pb were higher in infertility group. The concentrations of all metal components revealed no significant difference according to patients' age, resident, occupation, sperm density, motility and hormone level in blood plasma, but some metal components including Ca, Mg, Cu, Mn, Cd and Pb revealed a significant difference according to each these parameters except patient's age in seminal plasma. The concentrations of Mn, Cd and Pb in the vasectomy persons were higher than in the infertility group III including testicular and epididymal factors, but not in blood plasma. We conclude that the quantitative changes of metal components in the seminal plasma may have effects on not only spermatogenesis and sperm function, but also contribute to diagnostic parameter according to organ specificity of the metal in the male reproduction.
Busan ; Electrodes ; Fertility ; Humans ; Infertility ; Infertility, Male ; Male* ; Occupations ; Organ Specificity ; Plasma ; Reproduction ; Semen* ; Spermatogenesis ; Spermatozoa ; Vasectomy ; Volunteers

Bowen's disease is an intraepidermal squarnous cell carcinoma referred to also as squamous cell carcimona in situ. Approximately two-thirds of Bowen's disease consist of solitary lesion while remaining show multiple lesions, We experienced a 68-year old male patient who had multiple erythematous pathes and plaques covered with scales and grayish crusts developing on the trunk and both lower extremities. At first, clinically we suspected psoriasis, seborrheic keratosis, eczema and mycosis fungoides, and finally histopathologic features revealed Bowen's disease showing transformation to invasive squamous cell carcinorna.
Aged ; Bowen's Disease ; Carcinoma, Squamous Cell* ; Eczema ; Humans ; Keratosis, Seborrheic ; Lower Extremity ; Male ; Mycosis Fungoides ; Psoriasis ; Weights and Measures

A 4-year-old boy have had widespread, multiple, dark brownish, verrucous ]papular plaques on the neck, left chest, right side of abdomen, back and penile skin since birth. Clinical features and light and electron microscopic findings were consistent with ichthyosis hystrix. The patient was successfully treated with systemic administration of etretinate and vitamin E.
Abdomen ; Acitretin* ; Child* ; Child, Preschool ; Etretinate* ; Humans ; Ichthyosis* ; Male ; Neck ; Parturition ; Porcupines* ; Skin ; Thorax ; Vitamin E ; Vitamins

The pathogeoesis of papulonecrotic tuberculid had been thought to be the result of hernatogenous dissemination from primary tuberculous focus of other organs. But, today, the existence of papulonecrotic tuberculid as a rare cutaneous reaction to the Mycobacterium bacillus is questioned. Papulonecrotic tuberculid is, however, a real entity in underdeveloped countries where tuberculosis is more common. We report a case having papulonecrotie tuberculid associated with cervical lymph node tuberculosis confirmed by typical histopathology and by clinical response to antituberculous chemotherapy. This case supports Iden et al's view (1) that skepticism regarding the existence of papulonecrotic tuberculid is probably the result of the current decreased prevalence of untreated tuberculosis and consequently increased rarity of this entity.
Bacillus ; Drug Therapy ; Mycobacterium ; Prevalence ; Tuberculosis ; Tuberculosis, Cutaneous* ; Tuberculosis, Lymph Node

BACKGROUND: Alopecia areata, especially when severe, often profoundly affect the lives of those afflicted. Unfortunately, the clinical features and therapeutic results of alopecia areata are variable and unpredictable. OBJECTIVE: The authors performed a study on alopecia areata in order to evaluate the clinical manifestations and the effects of treatment with intralesional injections of triamcinolone acetonide suspension, immunotherapy with diphenylcyclopropenone(DPCP) and combination therapy of intralesional injections of triamcinolone acetonide suspension and immunotherapy with DPCP. METHODS: A clinical study of 357 patients with alopecia areata was performed fram March l994 to February l996 at the Department of Dermatology, Yongsan Hospital, College of Medicine, Chung- Ang University. RESULTS: 1) The age distribution showed a peak incidence in the third decade(36.1%) and the average age was 27.6 years. 2) The most common site of predilection was the occipiital region in both male and female, which were 127 cases(73.0%), 89 cases(64.5%) respectively. 3) The relapse rate was 26.1%. 4) The farnily histories were significant in 37 cases(10.4%). 5) Associated diseases with alopecia areata were seborrheic dermatitis, atopic dermatitis, hepatitis, diabetes mellitus, urticaria, allergic dermatitis, etc in 117 cases(32.8%). 6) The therapeutic effect in cases of bald areas treated with intralesional injections of triamcinolone acetonide, immunotherapy with DPCP and combination therapy revealed no difference based on increases in the size and number of bald areas. CONCLUSION: These findings suggest that alopecia areata prominently develops in the third decade, when the severity of alopecia areata increases and the therapeutic effect decrenses. There was no difference in the therapeutic effect on the size & number of balded areas.
Age Distribution ; Alopecia Areata* ; Alopecia* ; Dermatitis ; Dermatitis, Atopic ; Dermatitis, Seborrheic ; Dermatology ; Diabetes Mellitus ; Female ; Hepatitis ; Humans ; Immunotherapy ; Incidence ; Injections, Intralesional ; Male ; Recurrence ; Triamcinolone Acetonide ; Urticaria

BACKGROUND: Female diffuse hair loss is a common baldness with a multifactorial origin. In recent studies, it has been suggested that reduced or depleted iron stores are a cause of female diffuse hair loss. OBJECTIVE: We performed this study in order to elucidate the pathogenesis of female diffuse hair loss and to evaluate the differences in serurn iron levels between normal females and those with diffuse hair loss in Korea. METHODS: Blood levels of hemoglobin, iron, TIBC, ferritin, testosterone, thyroid function, ANA and Zn were examined in 30 patients with female diffuse hair loss and 20 normal females. RESULTS: 1) Serum Zn, testosterone, T4, TSH of the patient group were not statistically significant compared to those of the control group (p>0.05). 2) TIBC values were significantly increased, but serum ferritin levels were signifieantly decreased in the patient group (p<0.05). There were no significant differences in hemoglobin, serum iron in both groups (p>0.05). 3) No significant differences between clinical severity and the values of serum Zn, testosterone, T4, TSH, TIBC, serum femtin, hemoglobin and serum iron were observed (p>0.05). CONCLUSION: These findings suggested that the variations of TIBC, serum femtin levels may play a role in the pathogenesis of female diffuse hair loss, but further studies will be needed for evaluation of this condition.
Alopecia ; Female* ; Ferritins ; Hair* ; Humans ; Iron* ; Korea ; Testosterone ; Thyroid Gland

Ossification and calcification of the spinal ligaments frequently cause pressure upon the spinal cord andnerve roots. Authors reviewed 150 cases of C-spine CT, 80 cases of T-spine CT, and 725 cases of L-spine CT whichwere carried out a Pusan Natina University Hospital for 2 years from May 1983 to May 1985. We analysed 34 caseswhich showed ossification of posterior longitudinal ligament (OPLL) and ligamentum flavum (OLF) of these 955cases. The results are follows: 1. The male ot female ratio of spinal ligamentous ossification was 26:8. The 5thdecade group (24.41%) was the most prevalent age group. 4th decade(26.4%), 6th decade(23.52%), 7th decade(11.76),3rd decade (8.8%), and 8th decade(2.94%) in that order. 2. Of 955 cases of spine CT, the incidence of OPLL was 25cases(21.51%) and that of OLF was 10 ases(1.05%). 3. Regional incidence of spinal ligamentous ossification was asfollows. 1) In case of OPLL, cervical area was 19/150(12.67%) and lumbar area was 6/725 (0.83%). 2) In cases ofOLF, Thoracic area was 3/80(3.75%) and lumbar area was 8/725(1.10%). 4. The most frequent length of OPLL was 4body length (32%) and the most frequent locations are C4 and C5(68%). The types fo OPLL were 15 cases(60%) ofsegmental type, 8 cases(32%) of continuous type, and 2 cases(8%) of mixed type in that order. All segmental typeswere degree 1 or 2 and most continuous and mixed type (80%) were degree 2 or 3 dural sac effect. 5. The number ofinvolved interlaminar spaces in OLF was 1 to 5 interspaces and most of OLF were found at low thoracic and lumbararea. 6. There could be noted high correlation between the spinal ligamentous ossification and degenerative discdisease, The incidence of associated disc disease was 18/25(72%) in OPLL and 8/10(80%) in OLF.
Busan ; Female ; Humans ; Incidence ; Ligaments ; Ligamentum Flavum ; Male ; Ossification of Posterior Longitudinal Ligament ; Spinal Cord ; Spine

No abstract available.
Carcinoma, Hepatocellular* ; Survival Rate*

A 46-year-old male patient had recurrent episodes of generalized pruritic wheals during hemodialysis. He has experienced urticaria during hemodialysis whenever he used a capillary dialyser sterilized by ethylene oxide(EO, Polysulfone-) gas which is used to sterilize hemodialysers and other medical equipment. On the other hand, capillary dialyser sterilized by Gamma ray (Hemophad) has not evoked urticaria. Although the presence of EO-specific antibodies was not detected, urticarial rash never developed when the equipment was switched to a gamma-sterilized one. We herein report a case referred to ethylene oxide induced cutaneous hypersensitivity during hemodialysis.
Antibodies ; Capillaries ; Ethylene Oxide ; Exanthema ; Gamma Rays ; Hand ; Humans ; Hypersensitivity* ; Kidneys, Artificial ; Male ; Middle Aged ; Renal Dialysis* ; Urticaria