No abstract available.

No abstract available.

The patients initially underwent epikeratoplasty for keratoconus but a penetrating kerato plasty was required due to the opacity in the cornea. By using of this specimen, which was obtained by trephination the healing process of the host-Ienticule cornea could be examined by electron microscopy and immunofluorescence method. Epithelial ingrowth over the lenticule was well formed by the regeneration of the basement membrane over the Bowman's membrane. However, the poor attachment of the lenticule over the host corneal stroma made the interface easily separated during the sectioning processes. Electron microscopic study revealed the keratocytes in the lenticule stroma vacuolized with large number of degenerated microorganelles. These results suggest that it may take a long time to complete the wound healing of the host-Ienticule interface despite the epithelial ingrowth onto the lenticule was well formed.
Basement Membrane ; Bowman Membrane ; Cornea ; Corneal Stroma ; Epikeratophakia* ; Extracellular Matrix ; Fluorescent Antibody Technique ; Humans ; Keratoconus ; Microscopy, Electron ; Regeneration ; Trephining ; Wound Healing

Neurenteric cyst(enterogenous cyst) is a rare congenital lesion, usually affecting the lower cervical or upper thoracic areas, and its occurrence in cranial vault is even rarer. We present a patient with intracranial neurenteric cyst anterior to the pons and medulla oblongata. A 40-year old man presented with two-month history of occipital headache and facial spasm. The cyst was decompressed via far lateral suboccipital approach, and the patient recovered without permanent neurological deficits. Features on imaging studies and histological findings are discussed with the review of the literatures.
Adult ; Cranial Fossa, Posterior* ; Headache ; Humans ; Medulla Oblongata ; Neural Tube Defects* ; Pons ; Spasm

Clinical chemotherapy refractoriness is characterized by resistance to multiple drugs. Multidrug resistance(MDR) is caused by over-reactivity of a unidirectional drug efflux pump, transmembrane glycoprotein(P-glycoprotein), which is encoded by the MDR1 gene. P-glycoprotein leads to increased drug efflux and decreased intracellular drug concentration. Clinical trials that attempt to reverse or modulate MDR have been done. Cyclosporin-A and verapamil are the most extensively studied agents and several trials of cyclosporin-A as a MDR modulator have been reported. We report a case of an 8-year-old girl with acute mixed type leukemia who failed to respond 3 times to remission-induction therapy. It led us to conclude she had multidrug resistance. We tried a fourth induction chemotherapy including cytarabine, idarubicin and 6-thioguanine to which cyclosporin-A was added. Then, she showed signs of severe bone marrow depression and fulminant perianal cellulitis. But she recovered and successfully achieved complete remission. The addition of cyclosporine could be useful in achieving complete remission for cases of acute leukemia that resist to usual chemotherapy. Futher observation including more cases will be needed to assess long-term survival and efficacy of adding cyclosporine.
Bone Marrow ; Cellulitis ; Child ; Cyclosporine ; Cytarabine ; Depression ; Drug Resistance ; Drug Resistance, Multiple ; Drug Therapy ; Female ; Humans ; Idarubicin ; Induction Chemotherapy ; Leukemia* ; P-Glycoprotein ; Thioguanine ; Verapamil

PURPOSE: To investigate the perfusion of pulmonary nodules and the flow pattern revealed by electron beam tomography (EBT), and to evaluate their usefulness in the differential diagnosis of pulmonary nodules. MATERIALS AND METHODS: A prospective perfusion study involving 28 nodules in 23 men and five women (mean age, 57 years) was performed using EBT with the multislice flow mode. There were four phases. Precontrast density (Hounsfield units, HU) in phase 0; perfusion, peak HU and time to peak in phase 1; and mean HU and percentage decrease of HU to peak HU of phase 1 in phases 2 and 3 were measured and compared according to the diagnosis. RESULTS: Malignancy was diagnased in 19 cases [primary lung cancer (n=14); metastatic nodules (n=5)], while nine nodules were benign. Perfusion was significantly higher in malignant nodules than in benign (p<0.001) and a higher mean delay 1 HU (p<0.05) and a significantly short time to peak (p<0.05) were recorded in malignant nodules. In primary lung cancer cases, perfusion was significantly high compared with benign nodules (p<0.001), and a mean delay 1 HU was observed (p<0.05). There was no significant difference in perfusion between primary lung cancer and metastasis. CONCLUSION: Perfusion and flow pattern data measured by EBT can provide the useful information for differentiation between malignant and benign pulmonary nodules.
Diagnosis ; Diagnosis, Differential ; Female ; Humans ; Lung Neoplasms ; Male ; Neoplasm Metastasis ; Perfusion* ; Prospective Studies ; Tomography, X-Ray Computed*

Cutaneous leiomyoma is a rare benign tumor that originates from the smooth muscles derived from arrector pili muscles, the media of dermal blood vessels and the dartos muscle of the scrotum, vulva or nipples. Piloleiomyomas usually occur in the second to third decades of life with an equal incidence in men and women. They can be solitary, but multiple lesions are seen in 80% of these patients. Although multiple leiomyomas are often grouped, unilateral zosteriform pilar leiomyoma is rare. We report here on a rare case of grouped piloleiomyomas that presented as a zosteriform pattern on the right trunk of a 59-year-old woman.
Blood Vessels ; Female ; Humans ; Incidence ; Leiomyoma ; Male ; Middle Aged ; Muscle, Smooth ; Muscles ; Nipples ; Scrotum ; Vulva

No abstract available.
Adult* ; Humans

No abstract available.
Adult* ; Humans

PURPOSE: In evaluating the children with short stature, estimation of bone age is the primary step. Conventionally, radiologist estimates the bone age by comparing the radiographic image (left hand) of the child with the age-standardized atlas or by summing up the points given to individual bones of the hand and wrist. This method needs a skilled radiologist, causes radiation exposure, and it may take time. Recently, commercial ultrasonic method to estimate the bone age (BonAge(R), Sunlight Medical Ltd. Israel) was developed. We intended to compare the estimated bone ages using different methods-by radiographic and ultrasonographic methods. METHODS: One hundred and one boys and 108 girls over 5 years (all Koreans) who visited pediatric department from December 2004 to March 2005 for evaluation of short stature were evaluated. The radiologist estimated the bone age with Tanner-Whitehouse 2 method (Korean version). The ultrasonography was done in outpatient base by residents in pediatric department. We calculated the Pearson's correlation coefficients between each age and sex groups and compared the mean of each group by paired t-test. RESULTS: Ultrasonic bone age estimation was well correlated with radiologic method and was concordant with radiologic estimates in boys under age 12 and premenarchal girls of all ages and in postmenarchal girls under age 14. CONCLUSION: BonAge system could be easily performed without radiation. Further observation to more patients will be needed to see the accuracy of bone age estimation between ultrasonography and radiologic methods in older age group of Korean children.
Child ; Female ; Hand ; Humans ; Outpatients ; Sunlight ; Ultrasonics* ; Ultrasonography ; Wrist