BACKGROUND: Diabetes mellitus is a heterogeneous group of disorders characterized by high serum glucose levels and by disturbances of carbohydrate and lipid metabolism. There are many cutaneous signs of this common endocrinopathy, such as nercobiosis lipoidica diabeticorum, diabetic bullosis, shin spot, diabetic pruritus, etc. OBJECTIVE: In this study, we investigated whether extracellular matrix gene expression in cultured skin fibroblast is influenced by insulin and Insulin-like growth factor-I(IGF-I). METHOD: Total RNA was isolated from insulin or IGF-I treated human skin fibroblasts. The Northern blot and slot-blot hybridization were then conducted. RESULTS: The mRNA levels of pro α1(I) collagen, pro α1(I11) collagen, fibronectin in insulin and IGF-I treated normal skin fibroblasts increased compared with untreated normal skin fibroblasts. CONCLUSION: Our results show that insulin and IGF-I stimulate collagen formation in normal skin fibroblast at physiological concentrations. Therefore, these demonstrate that insulin can modulate the expression of extracellular matrix gene.
Blood Glucose ; Blotting, Northern ; Collagen ; Diabetes Mellitus ; Extracellular Matrix* ; Fibroblasts* ; Fibronectins ; Gene Expression ; Humans ; Insulin* ; Insulin-Like Growth Factor I ; Lipid Metabolism ; Methods ; Pruritus ; RNA ; RNA, Messenger ; Skin*

BACKGROUND: Exogenously administered epinephrine under enflurane anesthesia was known to have mild myocardial sensitizing effect. And N2O activates the sympathetic nervous system mildly. We planed this study to confirm cadiovascular effects of clinically administered epinephrine for hemostasis under the enflurane-N2O anesthesia during tonsillectomy. METHODS: Eighty children scheduled to have tonsillectomy were selected randomly and divided into 2 groups as follows; Group E: 1:100,000 epinephrine 2ug/kg and Group EL: 1:100,000 epinephrine containing 1% lidocaine 2 g/kg. Blood pressure, heart rate, and the occurrence of arrhythmia were evaluated before injection, at injection, 1 min, 2 min, 3 min, 5 min and 10 min after injection and 1 min after operation start. RESULTS: In both groups, systolic and diastolic blood pressure and heart rate are increased. But there are no significant statistical differences in each group and between groups. One min after operation, there are significant increases in systolic and diastolic blood pressure and heart rate in both groups (p<0.05), but there is no significant difference between groups. CONCLUSION: Under the enflurane-N2O anesthesia of children, 1:100,000 epinephrine 2ug/kg used for hemostasis could be used comparatively safe without any significant hemodynamic changes. But because there is always the possibility of myocardial sensitization, careful observation is necessary during epinephrine injection under the enflurane-N2O anesthesia.
Anesthesia* ; Arrhythmias, Cardiac ; Blood Pressure ; Child ; Enflurane ; Epinephrine* ; Heart Rate ; Hemodynamics ; Hemostasis* ; Humans ; Lidocaine ; Sympathetic Nervous System ; Tonsillectomy*

No abstract available.

No abstract available.
Cholecystectomy* ; Laparotomy*

No abstract available.
Vascular Access Devices*

No abstract available.

OBJECTIVE: The present study evaluated the characteristics and natural history of stroke patients. METHOD: Seven hundred and sixty seven consecutive patients admitted through acute care facility were reviewed. All medical records including age, case fatality, risk factors and radiological findings including CT or MRI were reviewed. To investigate the activities of daily living (ADL) of stroke patients, follow-up study was done in 303 patients through telephone interview or direct contact. Stroke was subdivided into cerebral infarct, intracerebral hemorrhage (ICH) and subarachnoid hemorrhage (SAH). RESULTS: The proportion of stroke subtypes were infarct (45.9%), ICH (34.7%) and SAH (19.4%). The recurrence rate of stroke was higher in the infarct patient. Higher percentage of fatality was noted in the SAH patient. Higher incidence of hemorrhage was still observed compared to western country. Hypertension is the major risk factors for all stroke subtypes. But among hypertensive individuals, only 29% patients controlled the hypertension. Fifty-eight percent of stroke patients regained independent ADL. CONCLUSION: The result of this study shows the clinical pictures of stroke patients. Further research was needed to investigate the trends of stroke and control of risk factors and attention must be paid to the patients who is dependent in ADL.
Activities of Daily Living ; Cerebral Hemorrhage ; Follow-Up Studies ; Hemorrhage ; Humans ; Hypertension ; Incidence ; Interviews as Topic ; Magnetic Resonance Imaging ; Medical Records ; Natural History ; Recurrence ; Risk Factors ; Stroke* ; Subarachnoid Hemorrhage

Flexor tendon injuries have long been considered one of the Problem areas for hand surgeons because of occasional unsatisfactory results of treatment. The authors reviewed 111 cases of flexor tendon injuries which were treated by primary repair in the Department of Orthopedic Surgery, Kyungpook National University Hospital for about 6 and a half years from Jan. 1977 to Aug. 1977. The results obtained were as follows; 1. Sex ratio between male and female was 4. 3: 1. 2. Age distribution showed the most frequent occurrence between 21 and 30 (38.7%). 3. Most of the patients were injured by glass (67.5%) and at the wrist level or proximal to it. 4. Average follow up period was 6 months and over-all end result was satisfactory in 83.9% by the Klienert criteria. 5. 9 cases of the 10 flexor pollicis longus only injured showed satisfactory result by the arbitrary criteria based on active flexion range of thumb i-p joint and functional difficulties in the daily living.
Age Distribution ; Female ; Follow-Up Studies ; Glass ; Gyeongsangbuk-do ; Hand ; Humans ; Joints ; Male ; Orthopedics ; Sex Ratio ; Surgeons ; Tendon Injuries ; Tendons ; Thumb ; Wrist

A lymphangioma, which is analogous in some ways to hemangioma due to a common origin, develop and grow in identical fashion and show certain common features in response to treatment, is a benign tumor composed of lymphatic tissue. But lymphangiomas are much less common than hemangiomas in frequency and most of these lesions are usually present at birth. Most of these lesions are found in the neck, few are located in the axilla and the remainders are scattered throughout the body. Soft tissue hyertrophy of the thenar eminance and proximal portion of index finger of left hand due to congenital lymphangioma, 7-months male baby, treated by surgical resection is presented with a review of the literature.
Axilla ; Fingers ; Hand ; Hemangioma ; Humans ; Lymphangioma ; Lymphoid Tissue ; Male ; Neck ; Parturition

No abstract available.
Factor V Deficiency* ; Factor V*