1.Does 'Hot Bath' have effect on experimental diabetic neuropathy?.
Won Ihl RHEE ; Seung Han YANG ; Young Shin PARK ; Byung Soon SHIN ; Keun Young PARK
Journal of the Korean Academy of Rehabilitation Medicine 1993;17(3):321-329
No abstract available.
Diabetic Neuropathies*
2.MR Imaging of Intracranial Calcification; Experimental and Clinical Studies.
Heoung Keun KANG ; Jeong Jin SEO ; Yun Hyeon KIM ; Jong Hoon YOON ; Byung Jin KIM ; Sung Yeul YANG
Journal of the Korean Radiological Society 1995;32(5):703-710
PURPOSE: This study was performed to evaluate MR signal intensity(SI) of calcification and to assess the capability of MRI in detection of various intracranial calcifications. MATERIALS AND METHODS: The MR findings and ROI value of experimental model of calcium carbonate suspension according to each concentration (20, 35, 50%) and diameter (1-10 mm) and hydroxyapatite suspension according to each concentration (10, 20, 30, 40, 50%) were analyzed. A specimen of calcification in cranio-pharyngioma was analyzed for its composition by XRD(X-ray diffractometer) and ICP(inductively coupled plasma) methods. MRI of 34 patients with intracranial calcifications were retrospectively analyzed for signal intensity of the calcification and its capability to detect calcifications according to size, location, and contrast with adjacent lesion. RESULTS: The calcium carbonate phantom with larger diameter and low concentration showed lower signal intensity on T2 than TlWl. Hydroxyapatite phantom showed high signal intensity in 10-30% concentration and low signal intensity in 40-50% concentration on T1 weighted image. The 5 cases of 34 intracranial calcifications showed high signal intensity on T1 weighted image. The capability of MRI in the detection of intracranial calcifications decreased in the circumstances such as small size(<2.5mm) and intraventricular location. Although the size of calcification was small, the detection was easy in the good contrast with adjacent lesion. However, the detection of the small sized calcification was easy if the contrast with adjacent lesion was good. CONCLUSION: lntracranial calcification shows generally low signal intensity on T1 and T2 weighted image with the exception of occasional high SI on TlWl. Detection of intracranial calcification in MRI is affected by its composition, size, location, and contrast with adjcent lesion.
Calcium Carbonate
;
Durapatite
;
Humans
;
Magnetic Resonance Imaging*
;
Models, Theoretical
;
Retrospective Studies
3.Delayed recovery of neuromuscular blockade by rocuronium in a hypothermic patient during a laparoscopic procedure: A case report.
Ji Keun RYU ; Byung Jun LEE ; Kyung A YANG ; Ouk JUNG
Korean Journal of Anesthesiology 2009;56(2):195-199
Perioperative hypothermia can occur frequently and lead to various complications. Laparoscopic procedures do not require a large incision or exposure of the viscera, but a prolonged and high pressure procedure can lead to unexpected hypothermia. Hypothermia prolongs the time-course of non-depolarizing neuromuscular blocking agents by reducing the plasma clearance significantly. Rocuronium, a new aminosteroidal neuromuscular blocking agent, can be influenced by reductions in plasma clearance and prolong the duration of action. Therefore, patients must receive ventilator care in the ICU. Aggressive measures were taken for hypothermia, and the patient was discharged without any complications. We report a case of delayed of neuromuscular blockade by rocuronium in a hypothermic patient during a laparoscopic procedure with a brief review of literatures.
Androstanols
;
Humans
;
Hypothermia
;
Laparoscopy
;
Neuromuscular Blockade
;
Neuromuscular Blocking Agents
;
Plasma
;
Ventilators, Mechanical
;
Viscera
4.Inspiratory and Expiratory HRCT Findings in Healthy Smokers' Lung.
Hyeon Seon PARK ; Byung Kook KWAK ; Chi Hoon CHOI ; Keun Mung YANG ; Chang Joon LEE ; Dong Il JOO ; Yang Soo KIM
Journal of the Korean Radiological Society 1998;38(5):823-828
PURPOSE: To evaluate the lung changes in healthy smokers, as seen on inspiratory and expiratoryhigh-resolution computed tomography (HRCT). MATERIAL AND METHODS: Twenty-seven healthy smokers (light smokers,below 20 pack-years, n=16; heavy smokers, above 20 pack-years, n=11) and 25 nonsmokers underwent inspiratory andexpiratory HRCT. All healthy smokers had normal pulmonary function and chest radiography. Parenchymal andsubpleural micronodules, ground-glass attenuation, centrilobular and paraseptal emphysema, bronchial wallthickening, bronchiectasis and septal line were evalvated on inspiratory scan and by air-trapping on expiratoryscan. RESULTS: On inspiratory scan, parenchymal micronodules were observed in one of 25 nonsmokers(4%), two of 16light smokers(13%) and five of 11 heavy smokers(45%); subpleural micronodules in two(8%), four(25%), two(18%);ground-glass attenuation in 0(0%), one(6%), three(27%); centrilobular emphysema in 0(0%), one(6%), three(27%);paraseptal emphysema in three(12%), 0(0%), five(45%); bronchial wall thickening in 0(0%), two(13%), one(9%),bronchiectasis in 0(0%), one(6%) two(18%) and septal line in one(4%), four(25%), two(18%). On expiratory scan,air-trapping was detected in 0 of 15 nonsmokers(0%), two of 17 light smokers(12%), and five of 11 heavysmokers(45%). Statistically significant differences between these three groups were found in parenchymalmicronodules(P=0.006), ground-glass attenuation(P=0.008), centrilobular emphysema(P=0.018), paraseptal emphysema(P=0.005) and air-trapping(P=0.013) between these three groups. CONCLUSION: According to the findings of HRCT,heavy smokers had higher frequency of parenchymal micronodules, ground-glass attenuation, centrilobular andparaseptal emphysema, and air-trapping than nonsmokers and light smokers.
Bronchiectasis
;
Bronchiolitis
;
Emphysema
;
Lung*
;
Pulmonary Emphysema
;
Radiography
;
Thorax
5.Change of plasma lipoproteins by heparin-released lipoprotein lipase.
Jeong Yeh YANG ; Tae Keun KIM ; Bon Sun KOO ; Byung Hyun PARK ; Jin Woo PARK
Experimental & Molecular Medicine 1999;31(2):60-64
Lipoprotein lipase (LPL) is known to be attached to the luminal surface of vascular endothelial cells in a complex with membrane-bound heparan sulfate, and released into blood stream by heparin. LPL that catalyzes hydrolysis of triglyceride (TGL) on chylomicron and VLDL into two fatty acids and monoacylglycerol, is also implicated to participate in an enhancement of cholesterol uptake by arterial endothelial cells in vitro. But little is known about the LPL-mediated cholesterol uptake in physiological state. In this study, changes in blood lipid composition and levels of lipoproteins were determined after the injection of heparin in human. The level of LPL in plasma was increased from 0 to 11 mU/ml within 30-40 min post-heparin administration and decreased to the basal level within 2 h. The level of TGL in plasma decreased from 70 mg/dl to 20 mg/dl within 1 h and gradually increased to 80 mg/dl within 4 h. However the level of total cholesterol in plasma remained at 140 mg/dl during an experimental period of 4 h. Analysis of Lipoproteins in plasma by NaBr density gradient ultracentrifugation showed that the level of VLDL decreased from 50 mg/dl to 10 mg/dl within 1-2 h and returned to normal plasm level at 4 h. However there were no significant changes in the level of LDL and HDL. These results suggest that, at least, in normo-lipidemic subjects, increased free plasm LPL acts primarily on VLDL and failed to show any significant uptake of cholesterol-rich lipoproteins in human.
Adult
;
Cholesterol/blood
;
Heparin/pharmacology*
;
Heparin/administration & dosage
;
Human
;
Immunoblotting
;
Lipoprotein Lipase/blood*
;
Lipoproteins/blood*
;
Lipoproteins, HDL/blood
;
Lipoproteins, LDL/blood
;
Lipoproteins, VLDL/blood
;
Triglycerides/blood
6.Chronic Recurrent Cholangitis Induced by Carbamazepine.
Sook Keun SONG ; Yang Je CHO ; Sang Hyun JANG ; Kyoung Sub KIM ; Byung In LEE ; Kyoung HEO
Journal of Korean Epilepsy Society 2007;11(2):106-108
Carbamazepine (CBZ) is one of the most commonly used antiepileptic agents. With its potent effects against seizure or neuropathic pain, it also has several undesirable adverse events. CBZ has been known to induce hepatotoxicity because the drug is mainly metabolized through hepatic system, and asymptomatic liver enzyme elevation occurs in 5~10% of patients receiving CBZ. There are several cases of symptomatic hepatitis or hepatic necrosis by CBZ, however, reports of chronic cholangitis associated with CBZ medication are rare. Here, we present a case of chronic recurrent cholangitis by CBZ with pathological evidence.
Anticonvulsants
;
Carbamazepine*
;
Cholangitis*
;
Hepatitis
;
Humans
;
Liver
;
Necrosis
;
Neuralgia
;
Seizures
7.Pathologic Analysis of Endomyocardial Biopsies in Heart Transplantation.
Mee Hye OH ; Jeong Wook SEO ; Kook Yang PARK ; Young Tak LEE ; Yoon Seop JEONG ; Suk Keun HONG ; Joon Ryang RHO ; Byung Hee OH ; Sung Sook KIM
Korean Journal of Pathology 1998;32(2):104-114
Endomyocardial biopsy (EMB) is a valuable diagnostic procedure for the surveillance of cardiac allograft rejection. Interpretation of individual cases is still problematic due to variations of findings for grading of rejection and other associated lesions. We reevaluated an experience on endomyocardial biopsies to develop better diagnostic criteria for rejection and other complications. Immunohistochemical studies against cytokines were performed to assess the usefulness of the method for the diagnosis or researches. A total of 249 EMBs taken from 33 cardiac allograft recipients were reviewed. There were 25 males and 8 females. Dilated cardiomyopathy was present (24 cases) and valvular heart disease (4 cases), restrictive cardiomyopathy (3 cases) were also common conditions. We applied the grading system of the International Society for Heart Transplantation (ISHT) for the assessment of acute cellular rejection. Grades of 0, 1A, 1B, 2, 3A and 3B were 39.0%, 28.1%, 11.2%, 11.5%, 12.4% and 1.6% respectively, but 3.2% were inadequate. Thirty five episodes of grade 3A or 3B were present in 17 patients. The response to therapy was assessed using a next follow up biopsy, which revealed resolving or resolved rejection in 85% of patients. The intensity of immunohistochemical stains for IL-6 and TNF-alpha was increased in proportion to the histologic grade but Quilty lesion and cardiomyopathy also showed a positive reaction. The other pathologic findings were ischemic change, previous biopsy site, interstitial edema and fibrosis, and Quilty lesion. These findings showed usefulness of endomyocardial biopsy not only for the evaluation of cardiac allograft rejection but also for the diagnosis of associated cardiac lesions. Immunohistochemical study of the cytokines was related to the degree of inflammation rather than degree of rejection.
Allografts
;
Biopsy*
;
Cardiomyopathies
;
Cardiomyopathy, Dilated
;
Cardiomyopathy, Restrictive
;
Coloring Agents
;
Cytokines
;
Diagnosis
;
Edema
;
Female
;
Fibrosis
;
Follow-Up Studies
;
Heart Transplantation*
;
Heart Valve Diseases
;
Heart*
;
Humans
;
Inflammation
;
Interleukin-6
;
Male
;
Tumor Necrosis Factor-alpha
8.A Case of Acute Hepatic Failure due to Acetaminophen Overdose Treated with Molecular Adsorbents Recirculating System(R).
Byung Keun YANG ; Je Sung YOU ; Young Seon JOO ; Sung Phil CHUNG ; Hahn Schick LEE
Journal of The Korean Society of Clinical Toxicology 2014;12(1):31-34
We report on a patient who developed acute hepatic failure despite intravenous N-acetyl cysteine therapy who was treated with the Molecular Adsorbents Recirculating System (MARS). She presented 20 hours after the ingestion of 13 g of acetaminophen. The MARS is based on albumin dialysis principle which can be applied for patients with acute poisoning from drugs that have high protein-binding capacity because of its ability to selectively remove from circulation protein-bound toxins. The clinical toxicologist should be consider this technology when treating patients with hepatic failure following acetaminophen poisoning.
Acetaminophen*
;
Cysteine
;
Dialysis
;
Eating
;
Humans
;
Liver Failure
;
Liver Failure, Acute*
;
Mars
;
Poisoning
9.A Case of Acute Hepatic Failure due to Acetaminophen Overdose Treated with Molecular Adsorbents Recirculating System(R).
Byung Keun YANG ; Je Sung YOU ; Young Seon JOO ; Sung Phil CHUNG ; Hahn Schick LEE
Journal of The Korean Society of Clinical Toxicology 2014;12(1):31-34
We report on a patient who developed acute hepatic failure despite intravenous N-acetyl cysteine therapy who was treated with the Molecular Adsorbents Recirculating System (MARS). She presented 20 hours after the ingestion of 13 g of acetaminophen. The MARS is based on albumin dialysis principle which can be applied for patients with acute poisoning from drugs that have high protein-binding capacity because of its ability to selectively remove from circulation protein-bound toxins. The clinical toxicologist should be consider this technology when treating patients with hepatic failure following acetaminophen poisoning.
Acetaminophen*
;
Cysteine
;
Dialysis
;
Eating
;
Humans
;
Liver Failure
;
Liver Failure, Acute*
;
Mars
;
Poisoning
10.Hypoglycemic Effects of Exo-biopolymers Produced by Five Different Medicinal Mushrooms in STZ-induced Diabetic Rats.
Byung Keun YANG ; Guk Nam KIM ; Yong Tae JEONG ; Hun JEONG ; Pradeep MEHTA ; Chi Hyun SONG
Mycobiology 2008;36(1):45-49
Hypoglycemic effects of exo-biopolymers (EBP) produced by submerged mycelial cultures of Coriolus versicolor, Cordyceps sinensis, Paecilomyces japonica, Armillariella mellea, and Fomes fomentarius were investigated in streptozotocin (STZ)-induced diabetic rats. The rats from each experimental group were orally administered with EBPs (100 mg/kg BW) daily for 2 weeks. Though the hypoglycemic effect was achieved in all the cases, however, C. versicolor EBP proved as the most potent one. The administration of the C. versicolor EBP substantially reduced (29.9%) the plasma glucose level as compared to the saline administered group (control). It also reduced the plasma total cholesterol (TC), triglyceride (TG), aspartate aminotransferase (AST) and, alanine aminotransferase (ALT) levels by 9.22, 23.83, 16.93, and 27.31%, respectively. The sugar and amino acid compositions of this EBP were also analyzed in detail.
Agaricales
;
Alanine Transaminase
;
Animals
;
Aspartate Aminotransferases
;
Cholesterol
;
Cordyceps
;
Coriolaceae
;
Glucose
;
Hypoglycemic Agents
;
Paecilomyces
;
Plasma
;
Rats
;
Streptozocin