BACKGROUND: Although the poor short-term outcome of antiepileptic drug (AED) treatment may represent long-term AED refractoriness in general, the same hypothesis in temporal lobe epilepsy (TLE) has yet to come up as an important subject to be investigated. We examined to decide early drug intractability and aid treatment plan. METHODS: From a prospective patient cohort of Yonsei Epilepsy Clinic, 121 newly-referred TLE patients were selected to participate in this study. First, we divided the patients into two groups according to their second one-year remission at two year of AED treatment. One group was the remission group (RG) and the other was the non-remission group (NRG). Second, we evaluated clinical characteristics influencing remission between the two groups. RESULTS: Nineteen patients (15.7%) were RG whereas 102 (84.3%) were NRG. The six month remission and terminal remission at the first year of AED treatment and the first one year remission rate in patients with RG was significantly higher than those with NRG (P<0.05). In patients with NRG, the number of complex partial seizures and secondary generalized seizures, the annual frequency of secondary generalized seizures prior to AED treatment, polypharmacy, new drug use, and drug side effects were significantly higher (p<0.05) than RG. CONCLUSIONS: The earlier seizure outcome may influence the later prognosis of AED treatment in non-lesional TLE. The prognosis during the second year of AED treatment is influenced by drug treatment and the number of generalized seizures.
Anticonvulsants ; Cohort Studies ; Epilepsy ; Epilepsy, Temporal Lobe* ; Humans ; Polypharmacy ; Prognosis* ; Prospective Studies ; Seizures ; Temporal Lobe*

No abstract available.
Humans ; Uterine Cervical Neoplasms*

No abstract available.

No abstract available.
Carcinoma, Hepatocellular* ; Classification*

BACKGROUND: In animal models of cerebral ischemic-reperfusion has been shown to have a beneficial effect. The object of this study is to compare the effect of pathologic findings between normotheimic and moderate hypothermic group. METHODS: We investigated the effect of moderate hypothermia induced 1 hour after transient(10 min) both carotid artery occlusion on the extent of ischemic-reperfusion cell damage in Mongolian Gerbil model. The terminal deoxyribonucleotidyl transferase (TdT) -mediated biotin-16-dUTP nick-end labelling(TUNEL staning) are used to detect apoptosis. RESULTS: 1. We suggest that Core body temperature is down to moderate hypothermia(30-32degrees C) beyond 10 minite by selective bain cooling method in Mongolian Gerbil model. 2. By light microscopy, ischemic-reperfusion damage were detected in the hippocampal CA1 pyramidal layer on the 3 day after transient ischemic insult, which showed chrosomal condensation and cytoplasmic eosinophilia. Ischemic-reperfusion cells were increased in the CA1 region on the 5 day. Apoptotic cells of the CA1 neurons seen by TUNEL staining than ischemic neurons seen by Hematoxylin-eosin staining were investigate 3 and 5 days after ischemic-reperfusion insult. CONCLUSION: We suggest that is not neuroprotective effects of Intraischemic(1 hour) moderate hypothermia in Gerbil brain global ischemic-reperfusion model.
Apoptosis ; Body Temperature ; Brain* ; Carotid Arteries ; Cytoplasm ; DNA Nucleotidylexotransferase ; Eosinophilia ; Gerbillinae* ; Hypothermia* ; In Situ Nick-End Labeling ; Microscopy ; Models, Animal ; Neurons ; Neuroprotective Agents*

BACKGROUND: An accurate and rapid method for specise identification of coagulase negative staphylococci(CNS) has been increasingly necessary for the clinical significance and planning the management of patients with staphylococcal infections. Recently, it has been reported that there is a highly conserved area on their 60KDa heat shock protein(HSP60) gene sequences between the interspecies of CNS and it can be amplified by a set of universal degenerate primer. This led us our attention to focus on whether the PCR-based RFLP method using Mse / restriction enzyme could be a useful tool for the species identification of CNS. METHODS: In the present study, we performed PCR-based RFLP analysis using a set of degenerate primers covering HSP60 and Mse / restriction enzyme on the reference strains and 25 clinical isolates(10 of S. epidermidis, 10 of S. haemolyticus, 4 of S. lugdunensis and 1 of S. warneri) which were previously identified by the API-STAPH, Vitek GPI card and/or with conventional biochemical test. RESULT: All the seven reference strains revealed that each strain has a distinct electrophoresed band patterns with combination of different number (up to 8) and size of fragments. And these distinct band patterns showed remarkable concordance with the seven reference strains and 25 clinical isolates. CONCLUSION: These result strongly suggest that the PCR-RFLP method using degenerate primers covering the HSP60 gene and Mse / digestion enzyme offer a convenient and accurate tool for species-specific identification of CNS.
Chaperonin 60* ; Coagulase* ; Digestion ; Heat-Shock Proteins* ; Hot Temperature* ; Humans ; Polymerase Chain Reaction ; Polymorphism, Restriction Fragment Length ; Shock ; Staphylococcal Infections

There are many procedures described for the treatment of acromioclavicular separation. Eleven cases were operated on by technique of Weaver and Dunn method and ten cases by modified Phemister method and four cases by Dewar and Barrington method, and one cases by Mumford method, Dept. of Orthopaedic Surgery, Capital Armed Forces General Hospital from March 1986 to March 1989. The following results were obtained. l. All patients were male and the peak incidence was in 3rd decade(77%). 2. The most common causes of the injuries were athletic accidents and followed by traffic accidents. 3. Twenty three patients were grade III by Allman's classification and grade II in three cases. 4. Clinical results were good in 19 cases(73.1%), fair in 5 cases(19.2%) and poor in 2 cases(7.7%). 5. The operative procedures in grade III may be good treatment of acromioclavicular separation.
Accidents, Traffic ; Arm ; Classification ; Hospitals, General ; Humans ; Incidence ; Joints ; Male ; Methods ; Sports ; Surgical Procedures, Operative

No abstract available.
Holoprosencephaly*

Transcatheter arterial chemoembolization(TACE) was performed in a 61 year old male patient with hepatocellular carcinoma with 10 cc of Lipiodol and 50 mg of doxorubicin. Three days later, he complained of dyspnea and dry cough. The arterial blood gas study revealed moderate hypoxemia and hypocarbia. The chest PA showed acute pulmonary edema with bilateral pleural effusion. To rule out the possibilities of acute respiratory failure caused by infection, pulmonary embolism or congestive heart failure, we performed several laboratory studies. The blood and sputum culture studies revealed negative results for bacterial growth. The echocardiogram was normal. The abdominal CT scan and MR imaging revealed no thrombus or mass lesion in the inferior vena cava. So we concluded pulmonary oil embolism induced by lipiodol as the cause of acute lung injury. Four weeks later, clinical symptoms and chest x-ray were markedly improved with conservative care. We report a case of acute lung injury after TACE with lipiodol and doxorubicin, with review of literatures.
Acute Lung Injury* ; Anoxia ; Carcinoma, Hepatocellular* ; Cough ; Doxorubicin ; Dyspnea ; Embolism ; Ethiodized Oil ; Heart Failure ; Humans ; Magnetic Resonance Imaging ; Male ; Pleural Effusion ; Pulmonary Edema ; Pulmonary Embolism ; Respiratory Insufficiency ; Sputum ; Thorax ; Thrombosis ; Tomography, X-Ray Computed ; Vena Cava, Inferior

No abstract available.
Female ; Pregnancy ; Pregnancy, Ectopic*