1.Teratological effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD): induction of cleft palate in the ddY and C57BL/6 mouse.
Byung Il YOON ; Tohru INOUE ; Toyozo KANEKO
Journal of Veterinary Science 2000;1(2):113-119
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD), a highly toxic halogenated aromatic hydrocarbon, is a teratogen to induce cleft palate when exposed during the pregnancy. There are inter-strain differences in the sensitivity to cleft palate induced by TCDD and other chemicals including polychlorinated terphenyls (PCTs). The C57BL/6 mouse and the ddY mouse had been shown to be different in the induction of cleft palate following the treatment of PCTs, which attempts us to evaluate the TCDD-induced cleft palate in two mouse strains to understand the mechanism through which TCDD and PCTs induce cleft palate. This study evaluated the induction of cleft palate in the fetuses of ddY and C57BL/6 mice after subcutaneous treatment of TCDD on gestation day (GD) 10.5-14.5 or oral treatment on GD 8.5-13.5. Our results clearly showed that ddY mice, a susceptible strain to PCTs-induced cleft palate, are resistant to the induction of cleft palate by TCDD comparably to the high susceptibility of C57BL/6 mice, suggesting a different teratological mechanism between TCDD and PCTs. In addition, at the low doses, our study supported the concept of "window effect" of TCDD on around GD 12 for the induction of cleft palate in C57BL/6 and ddY mice.
Administration, Oral
;
Animals
;
Cleft Palate/chemically induced/genetics/pathology/*veterinary
;
Female
;
Fetal Diseases/chemically induced/mortality/veterinary
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Incidence
;
Injections, Subcutaneous
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Male
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Mice
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*Mice, Inbred C57BL
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Polychloroterphenyl Compounds/toxicity
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Pregnancy
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Rodent Diseases/*chemically induced/genetics/pathology
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Teratogens/*toxicity
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Tetrachlorodibenzodioxin/administration & dosage/*toxicity
2.A case of seronegative enthesopathy and arthropathy syndrome (SEA syndrome).
Il Su KIM ; Jae Yoon KIM ; Byung Su CHO ; Sung Ho CHA ; Chang Il AHN
Journal of the Korean Pediatric Society 1992;35(10):1459-1462
No abstract available.
Rheumatic Diseases*
;
Spondylarthropathies
3.Computed tomographic findings of traumatic intracranial lesions
Seong Wook JEONG ; Il Young KIM ; Byung Ho LEE ; Ki Jeong KIM ; Il Gyu YOON
Journal of the Korean Radiological Society 1985;21(5):689-698
Traumatic intracranial lesion has been one of the most frequent and serous problem in neurosurgical pathology. CT made it possible to get prompt diagnosis and surgical intervention of intracranial lesions by its safety, fastiness and accuracy. Computed tomographic scan was carried out on 1309 cases at Soonchunhyang Chunan Hospitalfor 15 months from Oct. 1983 to Dec. 1984. We have reviewed the computed tomographic scans of 264 patients whichshowed traumatic intracranial lesion. The results were as follows: 1. Head trauma was the most frequentlydiagnosed disase using computed tomographic scans(57.8%), and among 264 cases the most frequent mode of injury wastraffic accident (73.9%). 2. Skull fracture was accompained in frequency of 69.7% and it was detected in CT in38.6%: depression fractue was more easily detected in 81%. 3. Countercoup lesion(9.5%) was usually accompained with temporal and occipital fracture, and it appeared in lower incidence among pediatric group. 4. Intracranial lesions of all 264 cases were generalized cerebral swelling(24.6%), subdural hematoma(22.3%), epiduralhematoma(20.8%), intracerebral hematoma(6.1%), and subarachnoid hemorrhage(3.0%). 5. The shape of hematoma wasusually biconvex(92.7%) in acute epidural hematoma and cresentic(100%) in acute subdural hematoma, but the morechronic the cases became, they showed planoconvex and biconvex shapes. 6. Extra-axial hematoma was getting decreased in density as time gone by. 7. Hematoma density was not in direct proportion to serum hemoglobin levelas single factor.
Chungcheongnam-do
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Craniocerebral Trauma
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Depression
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Diagnosis
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Hematoma
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Hematoma, Subdural, Acute
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Humans
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Incidence
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Pathology
;
Skull Fractures
4.Role of Redistribution and 24 Hour Reinjection Images to assess Myocardial Viability in Patients with Acute Myocardial Infarction.
Seok Nam YOON ; Moon Sun PAI ; Chan H PARK ; Myung Ho YOON ; Byung Il CHOI
Korean Journal of Nuclear Medicine 1998;32(4):325-331
PURPOSE: We evaluated the importance of redistribution and 24 hour reinjection images in Tl-201 SPECT assessment of myocardial viability after acute myocardial infarction (AMI). MATERIALS AND METHODS: We performed dipyridamole stress-4 hour redistribution-24 hour reinjection Tl-201 SPECT in 43 patients with recent AMI (4-16 days). The myocardium was divided into 16 segments and perfusion grade was measured visually with 4 point score from 0 to 3 (absent uptake to normal uptake). A perfusion defect with stress score 2 was considered moderate. A defect was considered severe if the stress score was 0 or l (absent uptake or severe perfusion decrease). Moderate defect on stress image were considered viable and segments with severe defect were considered viable if they showed improvement of 1 score or more on redistribution or reinjection images. We compared the results of viability assess-ment in stress-redistribution and stress-reinjection images. RESULTS: On visual analysis, 344 of 688 segments (50%) had abnormal perfusion. Fifty two (15%) had moderate perfusion defects and 292 (85%) had severe perfusion defects on stress image. Of 292 severe stress defects, 53 were irreversible on redistribution and reversible on reinjection images, and 15 were reversible on redistribution and irreversible on reinjection images. Two hundred twenty four of 292 segments (76.7%) showed concordant results on stress-redistribution and stress-reinjection images. Therefore 24 hour reinjection image changed viability status from necrotic to viable in 53 segments of 292 severe stress defect (18%). However, myocardial viability was underestimated in only 5% (15/292) of severe defects by 24 hour reinjection. CONCLUSION: The 24 hour reinjection imaging is useful in the assessment of rnyocardial viability. It is more sensitive than 4 hour redistribution imaging. However, both redistribution and reinjection images are needed since they complement each other.
Complement System Proteins
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Dipyridamole
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Humans
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Myocardial Infarction*
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Myocardium
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Perfusion
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Tomography, Emission-Computed, Single-Photon
5.Metastatic carcinoma of the thyroid to the skull: report of 2 cases
Dong Gie HAN ; Il Young KIM ; Byung Ho LEE ; Ki Jung KIM ; Il Gyu YOON ; Seung Ha YANG
Journal of the Korean Radiological Society 1985;21(4):552-557
Two cases of skull metastasis from thyroid carcinoma are presented. The one case shows multiple involvement inthe skull base with sphenoid sinus, frontal bone, and rib. The other case is solitary extensive involvement to theright parietal bone. The follicular caroinoma of the thyroid shows a strong tendency toward vascualr invasion and dissemination through blood stream to the lungs, bones, liver, brain, and other distant sites. The sternum, thevetebrae, and the pelvis are the most common sites in bone metastasis of thyroid carcinoma, followed by the femur,shoulder girdle, skull, and rib. Metastatic caroinoma to the skull base, including sphenoid sinus s extremelyrare. Authors experienced recently 2 cases of metastatic carcinoma of the thyroid to the skull and report withreview of literature.
Brain
;
Frontal Bone
;
Liver
;
Lung
;
Neoplasm Metastasis
;
Parietal Bone
;
Pelvis
;
Ribs
;
Rivers
;
Skull Base
;
Skull
;
Sphenoid Sinus
;
Sternum
;
Thyroid Gland
;
Thyroid Neoplasms
6.Experience of Marshall-Marchetti Operation in Stress Incontinence.
Chi Il HWANG ; Jong Byung YOON
Korean Journal of Urology 1981;22(3):322-326
The stress incontinence is a disease commonly developing in multipara and occurs by deficiency of estrogen and relaxation of pelvic organ generally after menopause but it is possible to occur before menopause by change in the structure of pelvic organ. Herin, we report 1 cases of stress incontinence, one nuliparous in pelvic trauma and remaining 3 cases in multipara. The diagnosis of stress incontinence was made by history, Marshall-Marchetti test and chain cystography. All cases underwent Marshall-Marchetti operation. After the operation, symptoms were improved in all cases and they have had satisfactory in usual life for 6 months to 4 years.
Diagnosis
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Estrogens
;
Female
;
Menopause
;
Relaxation
7.The effect of HLA mismatching on living kidney graft survivals.
Young Suk YOON ; Byung Kee BANG ; Won Il KIM ; Yong Bok KOH
The Journal of the Korean Society for Transplantation 1991;5(1):35-45
No abstract available.
Graft Survival*
;
Kidney*
;
Transplants*
8.The effect of HLA mismatching on living kidney graft survivals.
Young Suk YOON ; Byung Kee BANG ; Won Il KIM ; Yong Bok KOH
The Journal of the Korean Society for Transplantation 1991;5(1):35-45
No abstract available.
Graft Survival*
;
Kidney*
;
Transplants*
9.Percutaneous Bone Biopsy: Fluoroscopic Guidance.
Young Soo DO ; Byung Hee LEE ; Il Ju YOON ; Jin Joo LEE ; Soo Yil CHIN
Journal of the Korean Radiological Society 1994;30(2):375-378
PURPOSE: We evaluated the diagnostic accuracy and clinical usefulness of fluoroscopy-guided bone biopsy. MATERIALS AND METHODS: A total of 31 patients with various skeletal lesions underwent fluoroscopy-guided bone biopsies. The targets were long bones in 16 cases, pelvic bones in 7 cases, spines in 6 cases, and ribs in the rest 2 cases. RESULTS: The overall accuracy was 71%(22/31). The accuracy was 100% in case of primary sarcoma and multiple myeloma. But it was low in malignant lymphoma(1/4), malignant fibrous histiocytoma(0/1), and nonossifying fibroma(0/1). CONCLUSION: Percutaneous fluoroscopy-guided bone biopsy is a simple, safe, not-expensive, and rather accurate diagnostic procedure in evaluation of bone tumors. In addition to that, it is useful in the managment planning and fllow-up of the patients.
Biopsy*
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Humans
;
Multiple Myeloma
;
Pelvic Bones
;
Ribs
;
Sarcoma
;
Spine
10.Long-term effects of HLA matching on graft survivals in cyclosporine treated living kidney transplants.
Young Suk YOON ; Byung Ki BANG ; Won Il KIM ; Yong Bok KOH
The Journal of the Korean Society for Transplantation 1993;7(1):129-139
No abstract available.
Cyclosporine*
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Graft Survival*
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Kidney*
;
Transplants*