The tibial plafond fractures result from an axial compression snd rotational forces causing variable degrees of metaphyseal disruption, articular damage, and malleolar displscement. It is relatively uncommon but a most difficult fracture to manage. It has been treated in a number of manners, but the best results have been occurred when stable internal fixation is accomplished using plates and screws. Basic steps in reconstruction are restoration of anatomic length of the fibula with plate fixation, reconstruction of the tibial articular surface, cancellous bone grafting of the metaphyseal defect and buttress plating of the distal tibia. The suthor analysed the 20 cases of the tibial plafond frsctures in 17 patients, which were trested at the Department of Orthopedic Surgery, Paik Hospital, Inje Medical College from Jsnuary 1983 to March 1987. The longest durstion of followup was 2 years and 4 months and shortest one was 6 months, and the aversge was one year. The results were as follows : 1. Among the 17 patients, male were 16 and female was one. 2. The major causes of injury were a fall from a height. 3. The most frequent type of fracture was type C by Ruedi and Allgower classification. 4. Regardless of the method of trestment the type A and B were in good and fair result, but the type C were fair in 4 cases and poor in 8 cases. There were 7 cases of snkle fusion in poor group. 5. It is important to remind the basic steps in reconstruction and applied in sn individual csse especially in type C. If anatomic reconstruction of the joint surface can be restored and stable fixation achieved, esrly motion of the ankle joint is made possible. This early motion reduces stiffness of the ankle and win yeild the most sstisfying result. But the anatomic reduction of ank1 joint is difficult to be obtained in each case especially in type C and may consider an ankle fusion.
Ankle ; Ankle Joint ; Bone Transplantation ; Classification ; Clinical Study ; Female ; Fibula ; Follow-Up Studies ; Humans ; Joints ; Male ; Methods ; Orthopedics ; Tibia

No abstract available.
Factor V Deficiency* ; Factor V*

PURPOSE: To analyze serum markers in proximal femur fracture patients, which are known to be accompanied with osteophorosis or metabolic diseases, and consider it as predictive factor and to study how it affects on the fracture form. MATERIALS AND METHODS: Vit. D3 known as serum marker of Vit. D, 25(OH)D, and 1,25(OH)2D of 152 patients from April, 2013 to March, 2014 who visited our hospital and diagnosed as proximal femur fracture(Femur neck fracture 73, Intertrochanteric fracture 79) were analyzed. Also, serum calcium level corrected by serum protein, phosphate, creatinine, alkaline phosphatase, estradiol, IGF-1, and PTH were compared and analyzed. RESULTS: Femur neck fracture group showed significantly low value of D3, 25(OH)D, and 1,25(OH)2D (P-value<0.05) as the values were 37.72+/-7.21 pg/mL, 27.05+/-8.43 ng/mL, 25.05+/-6.78 pg/mL in femur neck fracture group, and 40.36+/-6.97 pg/mL, 29.54+/-9.12 ng/mL, 28.87+/-7.43 pg/mL in intertrochanteric fracture group respectively. The number of patients who were diagnosed as hypovitaminosis D. due to serum 25(OH)D value lower than 30ng/ml were significantly high in femur neck fracture group as the numbers were 56 in femur neck fracture, and 44 in intertrochanteric fracture. Serum calcium level corrected by serum protein, phosphate, creatinine, alkaline phosphatase, estradiol, IGF-1 and PTH level showed no significant difference between two groups. CONCLUSION: Serum 25(OH)D level was decreased in proximal femur fracture patiens, and was lower as the patient was older and BMD was lower. Therefore it is thought that proximal femur fracture is affected by vitamin D metabolism.
Alkaline Phosphatase ; Biomarkers ; Calcium ; Creatinine ; Estradiol ; Femoral Neck Fractures ; Femur ; Humans ; Insulin-Like Growth Factor I ; Metabolic Diseases ; Metabolism ; Neck ; Vitamin D

No abstract available.
Apoptosis* ; Caspase 3* ; Endothelial Cells* ; Perforin* ; Vibrio vulnificus* ; Vibrio*

To evaluate the expression of transforming growth factor-alpha(TGF-alpha) and proliferating cell nuclear antigen(PCNA) and its relation to the differentiation of the tumors, immunohistochemical studies were performed in 49 human gliomas. Tumors were graded by a 3-grade-system; grade I=low grade glioma, grade Il=anaplastic glioma, grade III=glioblastoma multiforme. TGF-A and PCNA were predominantly expressed in malignant gliomas compared with benign gliomas. Malignant gliomas revealed 87% TGF-A reactivity, while benign gliomas revealed 26% TGF-A reactivity. The proliferation index with PCNA was 26%+/-7%(mean+/-standard deviation) in malignant gliomas and 5%?% in benign gliomas. A strong positive correlation between tumor grade and extent of TGF-A and PCNA expression was found(P<0.0001, Chi square and P<0.002, T-test). Synchronous expression of TGF-A and PCNA was observed in 16 cases(33%). The results of this study support the suggestion that the expression of TGF-A might be a useful prognostic indicator in human gliomas.
Humans

PURPOSE: To assess the effectiveness and problems of the primary radiation therapy and salvage surgery in a series of patients affected by T1-T2 NO glottic cancers treated from 1985 to 1991 at the Pusan National University Hospital. MATERIALS AND METHODS: From 8.85 to 12/91, 34 patients affected by early glottic carcinoma histologically proven were treated with curative radiation therapy. Distribution of patients according to T stage was 30 for T1 and 4 T2. Male to female ratio was 33:1. Age of patients ranged from 31 to 73 with mean age of 58 years. All of the patients were treated with radical radiation with total tumor dose of 63-75. 3 Gy(median 68.2 Gy), of 5 weekly fractions of 1.8-2Gy and with 6MV photon beams through two laterally opposed fields. RESULTS: The overall 5-year local control rates were 74%(8/30) for T1, and 25%(3/4) for T2. The main cause of failure was progression or recurrence in T(10/11). One failures were observed in T and N at the same time. Of these 11 patients, 9(81%) were salvaged with surgery. After surgical salvage of radiation failures, the 5-year survival rates were 96% for T1 and 75% T2. Among the survivors, 73% of T1 and 33% of T2 were able to preserve the larynx. CONCLUSION: It can be concluded that radiotherapy is the first choice in the treatment of glottic T1 carcinoma.
Busan ; Female ; Humans ; Larynx ; Male ; Radiotherapy ; Recurrence ; Survival Rate ; Survivors

No abstract available.
Chordoma*

Epidermoid cysts occur rarely on the palms and soles, where hair is not present. These cysts have long been assumed to arise from traumatic implantation of epidermal fragment, but the pathogenesis is still controversial. Recently, with microscopic findings, immunohistochemical features, and molecular studies, the epidermoid cysts of the sole may be induced by the human papillomavirus. We report two cases of epidermoid cysts of the sole with the discussion of the pathogenesis.
Epidermal Cyst* ; Hair ; Humans*

PURPOSE: It is well known that the radiosensitivity of tumor cells can be significantly reduced under hypoxic conditions. Hypoxia-inducible factor-1alpha (HIF-1alpha) plays a pivotal role in the essential adaptive responses to hypoxia. Therefore this study investigated the relationship between HIF-1alpha expression and radiosensitivity. MATERIALS AND METHODS: Mouse hepatoma cell line hepa1c1c7 and HIF-1beta-deficient mutant cell line hepa1C4 were used to analyze the role of HIF-1alpha on radiosensitivity. These cells were exposed for 6 h to desferrioxamine (DFX) before radiation. HIF-1alpha expression was examined by Western blot. Apoptosis was assessed by DNA fragmentation, propidium iodide staining, and apoptotic cell death detection ELISA kit. Radiation sensitivity was determined using MTT assay. The radiobiological parameters, surviving fractions at 2 Gy and 8 Gy, and mean inactivation dose (MID) from the linear-quadratic model were used to assess radiation sensitivity in the statistical analyses. RESULTS: The expression of HIF-1alpha was increased, whereas apoptosis was decreased, by radiation in the presence of DFX in hepa1c1c7, but not in hepa1C4. The radiosensitivity of hepa1C4 cells was not significantly affected by DFX treatment. The radiosensitivity of hepa1c1c7 cells was significantly decreased in the presence of DFX CONCLUSION: The expression of HIF-1alpha by hypoxia-mimic agent DFX reduced apoptosis and radiosensitivity in mouse hepatoma cell line hepa1c1c7. These results suggested that HIF-1alpha could be induced by irradiation in hypoxic cells of tumor masses, and that this might increase radioresistance in hypoxic cells.
Animals ; Anoxia* ; Apoptosis ; Blotting, Western ; Carcinoma, Hepatocellular* ; Cell Death ; Cell Line* ; Deferoxamine* ; DNA Fragmentation ; Enzyme-Linked Immunosorbent Assay ; Mice* ; Propidium ; Radiation Tolerance

Congenital brachymetatarsia causes minor disability in daily life. However, patients suffer cosmetically or psychologically and often demand correction of the deformity when they reach adolescence. Thirty-eight skeletal lengthenings were performed on twenty-three patients with congenital brachymetatarsia between March 1992 and July 1993. Short metatarsal bones were osteotomized subperiosteally, and held by a small external fixator and then subjected to slow axial distraction. All the patients were female with an average age of patients at the time of operation was twenty-one years. The average lengthenings was 15.8mm. The average healing index was 80.6(day/cm). The average lengthenings percentage was 35.2%. There was a metatarso-phalangeal joint subluxation with pain in one patient. We believe that the callotasis method was no need for bone grafting and permitted early weight bearing. The result was good cosmetically.
Adolescent ; Bone Transplantation ; Congenital Abnormalities ; External Fixators ; Female ; Humans ; Joints ; Metatarsal Bones ; Methods ; Osteogenesis, Distraction ; Weight-Bearing