OBJECTIVE: We examined the vasoconstricting poperties of endothelin (ET) on isolated arteries from pregnant as well as non-pregnant uterus. METHODS: Arteries of the uterus were obtained from both hysterectomized uterus and during pregnany hysterectomy for control group and cesarean section for pregnant group. Rings of uterine artery were suspended on muscle chambers at their optimal length for generating tension and contractile properties were examined. RESULTS: ET-1 and ET-2 induced concentration-dependent constriction of both isolated arterial strips from non-pregnant and pregnant uterus. The contraction to ET-1 and ET-2 were more enhanced in full-term pregnancy. Furthermore, in pregnant group, sarafotoxin S6c and IRL 1620, ET. agonists, induced a dose-dependent contraction, which was not shown in those from non-pregnant human. Pretreatment of human uterine arterial strips from pregnant uterus with BQ610, an ET. antagonist, for 10 min resulted in a dose-related rightward shift of ET-1 response curve with diminution of maximal response. Schild plot analysis yielded a pA value of 7.29 with a slope of 0.98. However, BQ788, an ET antagonist, did not produce any rightward shift. The contraction to lower concentration (10-8~3*10-7 M) of sarafotoxin S6c was not affected by BQ788, whereas that to higher concentration (10-s-8*10-7 M) was marked diminished. However, BQ610 did not exnt any efFect on sarafotoxin S6c-induced contraction in arterial staips from pregnant uterus. When the bath solution was replaced with Ca-free physiological salt solution (PSS) containing 1 mM EGTA for 10 min prior to adding sarafotoxin S6c, sarafotoxin S6c-induced contraction was completely abolished. Sarafotoxin S6c (10 nM)-induced contraction was prefetentially blocked by a protein kinase C antagonist, H-7, whereas it was less sensitive to a calmodulin antagonist, calmidazolium, CONCLUSION: Based on above results, we concluded that ET plays an important role in regulating uterine blood flow through the activation of ETa and ETB receptors. Furthermote, ETB receptors may predominantly contribute to the modulation of human uterine circulation in full-term pregnancy.
1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine ; Arteries* ; Baths ; Calmodulin ; Cesarean Section ; Constriction ; Egtazic Acid ; Endothelin-2 ; Endothelins* ; Female ; Humans* ; Hysterectomy ; Pregnancy ; Protein Kinase C ; Receptors, Endothelin ; Uterine Artery ; Uterus*

Thirty-five cerebello-pontine angle lesions were diagnosed with simple skull X-ray, CT, and angiography atSeoul National University Hospital from Sept. 1978 through Aug. 1982. The radiographic findings were analysed withemphasis on the differential points of CT among the major three cerebello-pontine angle tumors; acousticneurinoma, meningioma and epidermoid. The results are as follows; 1. Among the 35 cases of cerebello-pontine anglelesions, 19 cases were acoustic neurinoma. 4 cases miningioma, 4 cases epidermoid, 2 cases metastasis, 1 caseschoroid plexus papilloma, 1 case arteriovenous malformation, and 3 cases intra-axial posterior fossa tumors. 2.The characteristic radiographic findings of acoustic neurinoma were windening of internal auditory canal, petrousbone erosion, posterior extension of tumor at the level of internal autidory canal, hypo or isodense mass onpre-contrast CT with high enhancement after intravenous contrast infusion, and cystic change within the mass. 3.Meningioma shows anterior extenstion of the lesion at the level of internal auditory canal, broad base and obtuseangle sign of the lesion with petrous bone, hyperdense mass on precontrast CT. with highly homogeneous enhancementafter intravenous contrast infusion. 4. Epidermoid characteristically shows hypodense mass on precontrast CT withno change after intravenous contrast infusion. 5. The differential points of the major 3 cerebello-pontine tumorswere bone change, mass location, attenuation , degree of attachment to petrous bone, and cystic change.
Angiography ; Arteriovenous Malformations ; Infratentorial Neoplasms ; Meningioma ; Neoplasm Metastasis ; Neuroma, Acoustic ; Papilloma ; Petrous Bone ; Skull

No abstract available.
Acetabulum*

We evaluated 38patients with orbital wall fracture, who were repaired surgically after its diagnosis from January 1986 to October 1995. We analysed its clinical symptoms and signs, ocular motlity disturbances and strabismus remaining after reduction. All the aptients showed diplopia due to ocular motility disturbance, it was greater in the patients with large fracture size and inferior wall fracture. The ocular motility disturbance remaining after the reduction was proportional to the fracture size and the time between trauma and its reduction. The exotropia and hypertropia of the fracturd eye were the main types of strabismus remaining after reduction. It was more severe in the patients with large fracture size and upper grade of ocular motility disturbance. The weakening procedure of horizontal and vertical muscle resulted in good correction for the strabismus.
Diagnosis ; Diplopia ; Exotropia ; Humans ; Orbit* ; Strabismus

AIDS, which is being spreaded world-wide, would have the number of the patients and the infected persons to several million persons since the first patient had been reported among the homosexualists in 1981, and in our country patients of 323 persons had been found till 1993, therfore we could have significant concern and warning. Accordingly, this writer intended to present basic data to the blood Project and AIDS preventive movement by investigating knowledge, attitude and concern regarding AIDS including blood donors, and analyzed data of 1,920 pages by questionaire method from March to August 1994. According to the results, it is rather well-known as far as general knowledge, attitude and concern regarding AIDS are concerned, however, items which are 20-40% wrongly known are as followings: AIDS is infected by virus. It is infected by insects such as mosquito. It is infected with tight kiss with the person infected with AIDS. Risk of being infected with AIDS will be reduced if using condom when sexual intercourse. It may be infected through the foods. It may be infected by the same bacteria attacking venereal disease. And WHO(world Health Organization) designated Dec. 1st as AIDS'Day. Items which are 40-60 wrongly known are as followings: AIDS can be infected by blood donation, Now vaccine preventing AIDS has been developed. In our country, Preventive law of AIDS is established. And in the field of the attitude and concern, it was surveyed as important as being hahdied by the broadcasting and newspaper, and 60470% of the persons answered that they would avoid AIDS infected person, and 76% of male and 87.1% of female gave the reply thet AIDS infected persons should be administered extraordinarily by isolated accommodation by the nation.
Bacteria ; Blood Donors* ; Coitus ; Condoms ; Culicidae ; Female ; Humans ; Insects ; Jurisprudence ; Male ; Periodicals ; Sexually Transmitted Diseases ; World Health Organization

Regular hemodialysis has been established as a way of treatment for end stage renal failure. In adults, hemodialysis 5 hours each time, three times weekly with one square meter hemodialyzer is now widely accepted as a standard, and there are many reports on long term follow up studies. Quite a large difference are present, however, in our community mainly originated from patient's poor compliance in frequent dialysis with short interdialysis interval. The author analyzed 200 cases of chronic renal failure who have received hemodialysis treatments during the 5 year period from July 1976 to June 1981 at the hemodialysis unit of the hanyang University Hospital and the following results are obtained; 1. Actual one year survival rate was much higher in thrice(87.1%) than one(35.1%) or twice(54.1%) weekly dialysis. 2. Long term(more than 6 months) complications were also more frequent in once(85.7%) or twice(70.2%) weekly treatments than in thrice(22.2%). The predominant complications were congestive heart failure, pericarditis, and infections. 3. Those who recieved three times weekly dialysis had better rehabilitation grades than the patients groups of twice or once weekly treatment. 4. Of peridialysis distressful symptoms, nausea, vomiting dizziness were less frequent in the group three times a week dialysis. In contrast, headache, hypotension, muscle cramps, and weakness were not significantly related with frequency of hemodialysis. 5. Those who voided a large amount of urine output had better survival and less frequent requirement of blood transfusions. 6. Main causes of death were due to patient poor compliance, hyperkalemia and cerebrovascular acidents. 7. Economic problems were the major cause of dialysis interruption.
Adult ; Blood Transfusion ; Cause of Death ; Compliance ; Dialysis ; Dizziness ; Follow-Up Studies ; Headache ; Heart Failure ; Humans ; Hyperkalemia ; Hypotension ; Kidney Failure, Chronic* ; Kidneys, Artificial ; Muscle Cramp ; Nausea ; Pericarditis ; Rehabilitation ; Renal Dialysis* ; Renal Insufficiency ; Survival Rate ; Vomiting

Atopic dermatitis is a common chronic inflammatory skin disease, associated with marked inflammatory cells (of mast cells and eosinophils) and severe itching, which leads to clinical problems in the pediatric population. This study was designed to investigate the inhibitory effects of luteolin liposome solution, that is entrapped the hydrophobic luteolin (one of the flavonoids) into ethosome to improve its stability, by using hapten-induced atopic dermatitis animal model (NC/Nga mice).The luteolin liposome treated mice showed anti-inflammatory effect as evidenced by the lowering of erythema and edema in clinical observation, reduction of inflammatory cell infiltration and epidermal thickness in histopathological examination, when compared with TNCB induced controls. Luteolin liposome solution also reduced the serum IgE level which played important roles in the atopic dermatitis model. These results suggest that luteolin liposome solution has some merit in this formulation showing inhibitory effects for the atopic dermatitis.
Animals ; Dermatitis, Atopic ; Edema ; Erythema ; Immunoglobulin E ; Liposomes ; Luteolin ; Mast Cells ; Mice ; Models, Animal ; Pruritus ; Skin Diseases

No abstract available.
Humans* ; Keratinocytes*

No abstract available.
Depression, Postpartum* ; Female ; Postpartum Period*

No abstract available.
Follow-Up Studies* ; Spinal Stenosis*