Traumatic implantation cyst of the conjunctiva has often been reported. We have observed two cases of conjunctival cyst following surgery of retinal detachment. A small vesicular lesion developed at the operation site of the conjunctiva about 5 weeks after the surgery. The cyst filled with clear fluid was located deep in the subconjunctival connective tissues. The wall of the cyst consisted of a few layers of epithelial cells very similar to the conjunctival epithelium and had not any direct connection with the overlying conjunctival epithelium. In order to prevent it a great care must be taken during surgery. A careful accurate apposition of the conjunctival wound will be required. An excessive and forceful retraction of the conjunctival flap for exposure of the operation field should be avoided. And also, an appropriate suture material (i.e. a round, tapered needle with smooth surfaced suture) seems to be necessary.
Conjunctiva ; Connective Tissue ; Epithelial Cells ; Epithelium ; Needles ; Retinal Detachment* ; Retinaldehyde* ; Sutures ; Wounds and Injuries

This study was undertaken to clarify the effects of glucocorticosteroids on intraocular pressure and the combined effects of acetazolamide and glucocorticosteroid on ocular pressure. Male and female rabbits, weighing 1.7-2.2kg, were divided into 5 groups: 1) saline-treated group, 2) hydrocortisone (0.5 %)-treated group, 3) prednisolone (0.5 %)-treated group, 4) fludrocortisone (0.1% )-treated group, 5) dexamethasone (0.1% )-treated group. Drugs were instilled 4 times a day for 3 weeks, and ocular pressure was checked in each group on second and third week. Following 3 weeks instillation of glucocorticoids, ocular pressure was checked in each animal at 15, 30, 60, and 120 minutes after intravenous administration of acetazolamide (10mg/kg). Under 0.5% tetracaine anesthesia, facility of outflow and flow rate of the aqueous humor were also measured with a tonometer. The results of the experiments were as follows: 1) The mean ocular pressure rose significantly in all glucocorticoid-treated groups, and the rise was especially marked in the dexamethasone-treated group. 2) The mean facility of outflow of the aqueous humor decreased significantly in the dexamethasonetreated group, but it remained with little change in the other glucocorticoidtreated group. 3) The ocular pressure-lowering action of acetazolamide was suppressed significantly at 30 minutes after the treatment with acetazolamide in the hydrocortisone and prednisolonetreated groups, but it was not suppressed in the fludrocortisone and the dexamethasonetreated groups. 4) The flow rate of the aqueous humor was suppressed significantly (36.2 %) at 30 minutes after the treatment with acetazolamide in the control group, but it was not suppressed significantly in g]ucocorticoid-treated groups.
Acetazolamide* ; Administration, Intravenous ; Adrenal Cortex Hormones* ; Anesthesia ; Animals ; Aqueous Humor ; Dexamethasone ; Female ; Fludrocortisone ; Glucocorticoids ; Humans ; Hydrocortisone ; Intraocular Pressure* ; Male ; Prednisolone ; Rabbits ; Tetracaine

A large osteoma arising from the ethmoid sinus produced exophthalmos and diplopia. The troublesome symptoms disappeared after surgical removal of the lesion. The osteoma was an ivory type.
Diplopia ; Ethmoid Sinus ; Exophthalmos ; Orbit* ; Osteoma*

Recently, various tube-shunt implants have been used in treating refractory glaucomas.They have large volumed reservoir portion made of hard materials.We made a new implant with soft and freely malleable membrane[expanded polytetrafluoroethylene, e-PTFE]as a reservoir portion attached to the conventional silicone tube. Based on the encouraging result from experimental animal study, we performed a clinical trial for the membrane-tube implant.We performed Glaucoma Tube-Shunt Implant surgery using double layers of e-PTFE membrane and silicone tube with its one end fixed between the two layers.The subjects had refractory glaucomas without useful vision who visited our hospital from May 1991 to Sep.1995. There were 40 eyes of 37 patients and their mean follow-up period was 32.6 months.We could control the IOP within 6~21 mms of mercury in 26 eyes[65.0%, Success].In remaining 14 eyes, we could not control the IOP or additional surgery was needed to control the IOP or treat severe complications[35.0%, Failure].The Kaplan-Meier Survival for IOP control was 78.4% at 1 yr, 71.6%at 2 yr, and 60.3%at 3 yr.The complications were similar to those of other commercially available Glaucoma implants. This new implant is made of soft, freely malleable membrane for the reservoir portion with small volume which can be inserted with smaller incision on the conjunctiva with less complication.We have obtained comparable result from this membrane-tube implant to other implants, and it may be considered as an another substitute for the treatment of refractory glaucomas.
Animals ; Conjunctiva ; Follow-Up Studies ; Glaucoma* ; Humans ; Membranes* ; Polytetrafluoroethylene ; Silicones

A patient complying with the clinical criteria for brain death was studied by preenhanced computed tomography (CT). Preenhanced CT showed apparent increased density at the base of the brain along the course of the major arterial vessels, and abnormally dense-appearing deep venous structures, like those of contrast-enhanced CT. There was a diffuse decrease in brain density with a poorly delineated ventricular system. These CT findings were very characteristic. CT as a non-invasive method seems to be valuable in the diagnosis of brain death. The relevant literature is reviewed and mechanisms showing those CT findings are discussed.
Brain Death/*radiography ; Humans ; Infant ; Male ; Perfusion ; *Tomography, X-Ray Computed

Intracranial hypoglossal neurinomas are rare and only about fifty cases have been reported worldwidely. They usually present with hypoglossal nerve palsy preoperatively. The authors experienced, however, two cases of intracranial hypoglossal neurinomas without preoperative hypoglossal nerve palsy. One patient was operated using transcondylar retrosigmoid approach with C1 laminectomy and the other using midline suboccipital craniectomy with C1 laminectomy. Postoperatively hypoglossal nerve palsy was developed in both cases. Absence of preoperative hypoglossal palsy seemed to be related to somewhat different growth pattern in these two cases. When the tumor shows typical radiological findings of hypoglossal neurinoma, it must be included in differential diagnosis despite absence of preoperative hypoglossal nerve palsy.
Diagnosis, Differential ; Humans ; Hypoglossal Nerve Diseases* ; Hypoglossal Nerve* ; Laminectomy ; Neurilemmoma* ; Paralysis

Eosinophilic gastroenteritis is an unusual disease characterized by eosinophilic infiltration of gastrointestinal tract, peripheral eosinophilia, and gastrointestinal symptoms. There are mucosal, muscular, and subserosal types, of which the subserosal type is the rarest. We experienced a 32-year old male patient with the subserosal type of eosinophilic gastroe-nteritis, who was presented with abdominal distension. The ascitic fluid revealed increased eosinophil count. With oral prednisolone, diarrhea and ascites rapidly disappeared and eosinophils in peripheral blood returned to normal. We report this case with a review of relevant literature.
Adult ; Ascites* ; Ascitic Fluid ; Diarrhea ; Eosinophilia ; Eosinophils* ; Gastroenteritis* ; Gastrointestinal Tract ; Humans ; Male ; Prednisolone

BACKGROUND: It is known that HLA molecule can restrict specific IgE responses, but few studies have documented the association between HLA and sensitization to house dust mite(HDM). OBJECTIVE: To evaluate whether a specific HLA type can be a risk or protective factor for the development of HDM sensitivity. METHOD: Total 146 subjects were genotyped for HLA-DRB1 using PCR-SSP technique and HDM sensitivity, determined by skin prick test using two mite allergens, D. pteronyssinus (Dp) and D. farinae (Df). Subjects were grouped according to Dp or Df sensitivity and linkage analysis between HDM sensitivity and HLA-DRB1 genotype was performed. RESULTS: The data revealed higher allele frequencies of DRB1*07 in Dp or Df sensitive groups compared to insensitive groups (11.6% vs. 2.6% in Dp, 11.5% vs. 3.3% in Df group, p<0.05), but the other allele frequencies showed no difference. CONCLUSION: There was a significant association between HLA-DRB1*07 genotype and HDM sensitization. These results indicate that antigen presentation by HLA class II molecule restricts the development of specific IgE response to HDM.
Allergens ; Antigen Presentation ; Dust* ; Gene Frequency ; Genotype* ; HLA-DRB1 Chains* ; Immunoglobulin E ; Mites ; Pyroglyphidae* ; Skin

Asthma and chronic obstructive pulmonary disease (COPD) are characterized by chronic airway inflammation resulting in airflow limitation. They include various phenotypes and endotypes in their disease entities. For that reason, they lack proper biomarkers and epoch-making progresses in treatment nowadays. Healthy airway has been believed to be sterile traditionally. However, with the help of nonculture sequencing techniques, researchers discovered that it is full of the commensal and symbiotic microbial flora. Therefore, microbiome has emerged as a possible biomarker and a clue to understand the pathogenesis of airway disease. Microbiome research in asthma has focused on the association between characteristics of microbiome, such as composition and diversity. However, now it refers to the role of microbiome, including Proteobacteria, in the development and pathogenesis of asthma and allergic diseases. Microbiome research in COPD has revealed its different composition according to the existence and severity of the disease. Also, differences in microbiome composition according to exacerbation state or specific treatment of COPD are reported. Therefore, many researchers pay attention to the possible role of microbiome as a biomarker or a treatment target in asthma and COPD. Herein, we review recent studies on microbiome research in asthma and COPD.
Asthma* ; Biomarkers ; Inflammation ; Microbiota* ; Phenotype ; Proteobacteria ; Pulmonary Disease, Chronic Obstructive* ; Research Design

Food-dependent exercise-induced anaphylaxis(FDEIAn), first reported in 1979, is a rare condition characterized by acute cutaneous, gastrointestinal, cardiovascular, and respiratory symptoms occurring on exertion after certain meals. This article describes 3 patients who developed urticaria, dizziness, abdominal pain, and loss of consciousness if the ingestion of wheat flour-food was followed by exercise within 2 hours. But either exercise or wheat intake alone did not induce any symptoms. Skin prick test showed strong positive responses to wheat flour and bread in all patients. We could diagnose FDEIAn with specific food-exercise challenges.
Abdominal Pain ; Anaphylaxis* ; Bread ; Dizziness ; Eating ; Flour ; Humans ; Meals ; Skin ; Triticum ; Unconsciousness ; Urticaria