This relatively uncommon malignant melanoma (incidence less than 5/100, 000 population) is attested to by the fact that despite accounting for only 3% of all cutaneous malignant neoplasms and causes 67% of the deaths attributabIe to skin cancer. Sunlight pIays a major role in. the development of melanoma. Several factors influence the clinical course of malignant melanoma, such as sex, site, type of ma1ignant melanoma, degree of cellular anaplasia, inflammatory reaction and thickness of the lesion. Two caees of malignant melanoma were presented. The one was 55 year old male who had been suffered from large pea sued blackish ulcerative lesion on the lft sole aince 3 years before. The other one was 66 year old female wha had been suffered frorn walnut sized ulcerative lesion on the right inner wrist joint with regional lymph adenopathy since 2 yea,ra before. The patient was treated with wide surgical excision, regionaI lymphnode dissection and subcutaneous injection with Tubercin-3. The first male patient was treated completely but second female patient shows recurrence of the lesion on the right forearm and upper arm within 40 days.
Aged ; Anaplasia ; Arm ; Female ; Forearm ; Humans ; Injections, Subcutaneous ; Juglans ; Male ; Melanoma* ; Middle Aged ; Peas ; Recurrence ; Skin Neoplasms ; Sunlight ; Ulcer ; Wrist Joint

BACKGROUND AND OBJECTIVES: The development of coronary intervention registry system is required for analysis of current status and more efficient management of patients with coronary artery disease in Korea. We developed database system and registry system in internet environment to confirm the possibility of nationwide system construction and of useful information providing on coronary intervention. MATERIALS AND METHOD: Database for coronary intervention and web-based registry system were developed and installed on internet server. Data elements consist of demographics, coronary risk factors, initial diagnosis, lesion characteristics, type of interventional procedures, and post-procedure outcomes. RESULTS: Total 734 patients were registed by 12 intervention centers from November 1998 to October 1999. Patients with angina pectoris and myocardial infarction were 78.5% and 21.5%, respectively and 14.6% of all patients had history of previous coronary intervention. Major coronary risk factors of the patients were smoking (38.6%), hypertension (33.8%), and diabetes (18.0%). Proportions of the patients with single-vessel disease, two-vessel disease, and triple-vessel disease were 64.7%, 26.2%, and 9.1%, respectively. Left main disease was detected in 2.0%. Balloon PTCA only was performed in 209 patients and 530 patients underwent coronary stent insertion. CONCLUSION: Multicenter data of coronary intervention were collected via internet-based system, and it was possible to construct intervention database. These web-based systems linked with database will provide status of Korean interventional procedures and be able to support multicenter study efficiently by expanding the participating hospitals and including more detailed database fields.
Angina Pectoris ; Coronary Artery Disease ; Demography ; Diagnosis ; Humans ; Hypertension ; Internet ; Korea ; Myocardial Infarction ; Risk Factors ; Smoke ; Smoking ; Stents

No abstract available.

At first, we review a sample size estimation method for log-rank test in survival analysis. Although it is widely used these days, it has a weakness for practical use. We propose a modification method to avoid the weakness.
Sample Size*

Agnogenic myeloid metaplasia (AMM) is a myeloproliferative disorder characterized by leukoerythroblastosis, tear-drop erythrocytes, extramedullary hematopoiesis with hepatosplenomegaly, and varying degrees of myelofibrosis. The mean age at presentation is about 60 years, and pediatric cases are rare. We experienced a case of AMM in a 9 months old female who was presented with pallor, huge splenomegaly and intermittent fever. Peripheral blood showed leukoerythroblastosis poikilocytosis, and tear drop cells. Bone marrow was difficult to aspirate, and biopsy specimen showed increased reticulin with decreased cellularity, which was compatible with myelofibrosis. We presented a case of AMM with brief review of the literatures.
Biopsy ; Bone Marrow ; Erythrocytes ; Female ; Fever ; Hematopoiesis, Extramedullary ; Humans ; Infant ; Myeloproliferative Disorders ; Pallor ; Primary Myelofibrosis* ; Reticulin ; Splenomegaly

Mandibular retrusion showing the facial problem with a marked maxillarry incisors protrusion and chin deficiency, resulting in a highly convex profile is uncommon in Korea.. The large incisor overjet and deep-bite create functional limitations and unpleasing esthetic result. The majority of theses cases are susceptible to correction by orthodontic therapeutic methods. But severe Class II retrognathic cases in which orthodontic treatment alone has not been capable of achieving good results. Orthognathic surgery offers several approaches. In this case, mandibular advancement by bilateral sagittal split ramus osteotomy and augmentation genioplasty has a special surgical problems. The suprahyoid muscle gorup are lengthened if the body of the mandible is surgically repositioned anteriorly. Instability of results and relapse return to original position shoud predicted during post-surgical muscular readjustment.. To maintain maximum correction with this technique, it is suggested that the mandibular body be well rotated forward at time of surgical intervention and overcorrected anteriory as much as possible. So, the authors report the case with review of concerned literature.
Chin ; Genioplasty ; Incisor ; Korea ; Mandible ; Mandibular Advancement ; Orthognathic Surgery ; Osteotomy, Sagittal Split Ramus ; Overbite ; Recurrence ; Retrognathia*

BACKGROUND: Paraquat is a widely used herbicide, known to cause lethal toxicity in humans. Most studies about paraquat have concentrated on systemic toxicity, however several cases of paraquat-induced dermatitis have been reported. OBJECTIVE: The purpose of this study was to confirm the cutaneous toxic effect of paraquat and to select potential antidotes in paraquat-induced dermatitis. METHODS: Keratinocyte toxicity due to paraquat and the toxicity reduction capacity of several drugs were investigated in eitro. Topical effects of these drugs on paraquat-induced dermatitis in guinea pig skin was also investigated. RESULTS: Over 50% of keratinocytes failed to survive at a concentration of 2X10-4M paraquat by a neutral red uptake assay. Skin irritation by paraquat was observed at 2% concentration by non-invasive methods as well as a skin biopsy. Dexamethasone, glutathione and tocopherol showed some capacity to reduce paraquat-induced keratinocyte toxicity in vitro. Only dexamethasone, however, showed a reduction of cutaneous blood flow volume and dermal inflammatory cell infiltration in the guinea pig study. CONCLUSION: This result indicates the possible in eitro protective effect of paraquat toxicity in glutathione and tocopherol. Dexamethasone was capable of reducing paraquat-induced cytotoxicity and dermatitis both in vitro and in vivo.
Animals ; Antidotes* ; Biopsy ; Dermatitis ; Dexamethasone ; Glutathione ; Guinea Pigs ; Humans ; In Vitro Techniques ; Keratinocytes ; Neutral Red ; Paraquat* ; Skin* ; Tocopherols

Single photon emission computed tomographic(SPECT) imaging, performed at oral and maxillofacial surgery department, is valuable in assessing temporomandibular dysfunction, looking for metastases in patients with malignancies, diagnosing facial asymmetry. Conventional planar scintigraphy is limited by two-dimensional representation of three-dimensional structures. The SPECT exam, by sectioning through a distribution of tracer, eliminates the obscuring effects of tracer located outside the plane of interest. In our department, we used this image for four type cases retrospectively. 1. Those patients who have facial asymmetry 2. To find metastases in patients with malignacies 3. In combination with magnetic resonance imagine, to confirm the diagnosis of internal joint derangement 4. To evaluate the viability of grafted bone. Recently, this image is able to be used in those patients whose symptoms etiology cannot be explained by other diagnostic techniques.
Diagnosis ; Facial Asymmetry ; Humans ; Joints ; Neoplasm Metastasis ; Radionuclide Imaging ; Retrospective Studies ; Surgery, Oral ; Tomography, Emission-Computed, Single-Photon* ; Transplants

No abstract available.
Pulmonary Atelectasis*

No abstract available.
Rhabdomyosarcoma*